|Official Full Name||coiled-coil domain containing 50|
|Background||This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.|
|Synonyms||CCDC50; coiled-coil domain containing 50; C3orf6, deafness, autosomal dominant 44 , DFNA44; coiled-coil domain-containing protein 50; Ymer; protein Ymer; C3orf6; DFNA44|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ccdc50 involved in several pathways and played different roles in them. We selected most pathways ccdc50 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ccdc50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
ccdc50 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ccdc50 itself. We selected most functions ccdc50 had, and list some proteins which have the same functions with ccdc50. You can find most of the proteins on our site.
|protein binding||MKL1; HSPA1A; HNRNPH3; CTDSP1; GPX3; RBBP4; IGBP1; SLC25A18; PIH1D2; ARFIP2|
|ubiquitin protein ligase binding||YOD1; CUL5; SQSTM1; LRPPRC; MAP1LC3B; TRAF4; SUMO1; WASH; DERL1; VCP|
ccdc50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccdc50 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccdc50.
OTUD7B; RIPK1; UBB; RPS3A; q81sn0_bacan; MYH9; Calml3; LIMA1; Coro1c