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Official Full Name coiled-coil domain containing 50
Background This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms CCDC50; coiled-coil domain containing 50; C3orf6, deafness, autosomal dominant 44 , DFNA44; coiled-coil domain-containing protein 50; Ymer; protein Ymer; C3orf6; DFNA44
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ccdc50-2008M Recombinant Mouse Ccdc50 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CCDC50-375H Recombinant Human CCDC50 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human CCDC50-0558H Recombinant Human CCDC50 Protein, GST-Tagged Wheat Germ GST
    Human CCDC50-7763HCL Recombinant Human CCDC50 293 Cell Lysate HEK293 N/A
    Rat CCDC50-1188R Recombinant Rat CCDC50 Protein Mammalian Cell His
    Chicken CCDC50-2969C Recombinant Chicken CCDC50 Mammalian Cell His

    ccdc50 involved in several pathways and played different roles in them. We selected most pathways ccdc50 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ccdc50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    ccdc50 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ccdc50 itself. We selected most functions ccdc50 had, and list some proteins which have the same functions with ccdc50. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MKL1; HSPA1A; HNRNPH3; CTDSP1; GPX3; RBBP4; IGBP1; SLC25A18; PIH1D2; ARFIP2
    ubiquitin protein ligase binding YOD1; CUL5; SQSTM1; LRPPRC; MAP1LC3B; TRAF4; SUMO1; WASH; DERL1; VCP

    ccdc50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccdc50 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccdc50.

    OTUD7B; RIPK1; UBB; RPS3A; q81sn0_bacan; MYH9; Calml3; LIMA1; Coro1c

    Liggins, AP; Cooper, CDO; et al. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. BRITISH JOURNAL OF HAEMATOLOGY 138:479-486(2007).
    Teng, F; Kawalec, M; et al. An Enterococcus faecium secreted antigen, SagA, exhibits broad-spectrum binding to extracellular matrix proteins and a appears essential for E-faecium growth. INFECTION AND IMMUNITY 71:5033-5041(2003).

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