Recombinant Full Length Human CCDC50 Protein, GST-tagged

• Cat.No.: CCDC50-2865HF
• Product Overview: Human CCDC50 full-length ORF (AAH65004.1, 1 a.a. - 306 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 60.06 kDa
• Protein Length: 306 amino acids
• AA Sequence: MAEVSIDQSKLPGVKEVCRDFAVLE DHTLAHSLQEQEIEHHLASNVQRNR LVQHDLQVAKQLQEEDLKAQAQLQK RYKDLEQQDCEIAQEIQEKLAIEAE RRRIQEKKDEDIARLLQEKELQEEK KRKKHFPEFPATRAYADSYYYEDGG MKPRVMKEAVSTPSRMAHRDQEWYD AEIARKLQEEELLATQVDMRAAQVA QDEEIARLLMAEEKKAYKKAKEREK SSLDKRKQDPEWKPKTAKAANSKSK ESDEPHHSKNERPARPPPPIMTDGE DADYTHFTNQQSSTRHFSKSESSHK GFHYKH
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CCDC50 coiled-coil domain containing 50 [ Homo sapiens ]
• Official Symbol: CCDC50
• Synonyms: CCDC50; coiled-coil domain containing 50; C3orf6, deafness, autosomal dominant 44, DFNA44; coiled-coil domain-containing protein 50; Ymer; protein Ymer; YMER; C3orf6; DFNA44
• Gene ID: 152137
• mRNA Refseq: NM_174908
• Protein Refseq: NP_777568
• MIM: 611051
• UniProt ID: Q8IVM0