Recombinant Full Length Human CCDC50 Protein, C-Flag-tagged

• Cat.No.: CCDC50-1788HFL
• Product Overview: Recombinant Full Length Human CCDC50 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 35.6 kDa
• AA Sequence: MAEVSIDQSKLPGVKEVCRDFAVLE DHTLAHSLQEQEIEHHLASNVQRNR LVQHDLQVAKQLQEEDLKAQ AQLQKRYKDLEQQDCEIAQEIQEKL AIEAERRRIQEKKDEDIARLLQEKE LQEEKKRKKHFPEFPATRAY ADSYYYEDGGMKPRVMKEAVSTPSR MAHRDQEWYDAEIARKLQEEELLAT QVDMRAAQVAQDEEIARLLM AEEKKAYKKAKEREKSSLDKRKQDP EWKPKTAKAANSKSKESDEPHHSKN ERPARPPPPIMTDGEDADYT HFTNQQSSTRHFSKSESSHKGFHYK H TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: CCDC50 coiled-coil domain containing 50 [ Homo sapiens (human) ]
• Official Symbol: CCDC50
• Synonyms: YMER; C3orf6; DFNA44
• Gene ID: 152137
• mRNA Refseq: NM_174908.4
• Protein Refseq: NP_777568.1
• MIM: 611051
• UniProt ID: Q8IVM0