CCL13
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Official Full Name
chemokine (C-C motif) ligand 13 -
Overview
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. -
Synonyms
CCL13;chemokine (C-C motif) ligand 13;NCC1;CKb10;MCP-4;NCC-1;SCYL1;SCYA13;MGC17134;C-C motif chemokine 13;CK-beta-10;OTTHUMP00000163804;new CC chemokine 1;small-inducible cytokine A13;monocyte chemotactic protein 4;monocyte chemoattractant protein 4;small inducible cytokine subfamily A (Cys-Cys), member 13;MCP4
Recombinant Proteins
- Human
- CHO
- E.coli
- Wheat Germ
- Yeast
- HEK293
- Human Cells
- In Vitro Cell Free System
- Fc
- GST
- Non
- His
- Flag
Involved Pathway
CCL13 involved in several pathways and played different roles in them. We selected most pathways CCL13 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TNFSF13B,IKBKG,LAT,LRDD,Bcl2a1b,CCL21B,BIRC3,CD40LG,IL1B,DDX58 |
| Chemokine signaling pathway | VAV3,GNB1,AKT1,CRK,GNAI2,CCR8,VAV2,CXCR5,RAF1,GNG13 |
| Cytokine-cytokine receptor interaction | LIFRA,KIT,BMP7,TNFRSF11A,IL3RA,TNF,IL17RB,IL7R,IRX1,IL25 |
Protein Function
CCL13 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL13 itself. We selected most functions CCL13 had, and list some proteins which have the same functions with CCL13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | SNX17,CXCL10,DAO1,FRK,FZD8,SRC,HCST,SRPX2,PVRL1B,IDH1 |
| chemokine activity | CCL5,CXCL10,CCL27,CCL20B,CXCL14,CCL6,CXCL11,CXCL2,PF4V1,CKLF |
| CCR chemokine receptor binding | CCL33.3,CCL38A.4,CCL3L3,XCL1,XCL2,CCL24,CCL20A.3,CCL22,CCL20B,CCL34A.4 |
Interacting Protein
CCL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL13.
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References
- Agrawal, S; Townley, RG; et al. Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma. EXPERT OPINION ON BIOLOGICAL THERAPY 14:165-181(2014).
- Lechner, CJ; Gantin, RG; et al. Chemokines and cytokines in patients with an occult Onchocerca volvulus infection. MICROBES AND INFECTION 14:438-446(2012).
