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Official Full Name cyclin D2
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]
Synonyms CCND2; cyclin D2; KIAK0002; G1/S-specific cyclin-D2; G1/S-specific cyclin D2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCND2-0659H Recombinant Human CCND2 Protein, GST-Tagged Wheat Germ GST
    Human CCND2-10861H Recombinant Human CCND2, GST-tagged E.coli GST
    Human CCND2-20H Recombinant Human CCND2 protein, GST-tagged E.coli GST
    Human CCND2-2612H Recombinant Human CCND2 protein, His & T7-tagged E.coli His/T7
    Human CCND2-27757TH Recombinant Human CCND2, His-tagged E.coli His
    Human CCND2-320H Recombinant Human Cyclin D2, His-tagged E.coli His
    Human CCND2-6157H Recombinant Human CCND2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCND2-7712HCL Recombinant Human CCND2 293 Cell Lysate HEK293 N/A
    Human CCND2-894H Recombinant Human CCND2 protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ccnd2-2613M Recombinant Mouse Ccnd2 protein, His & T7-tagged E.coli His/T7
    Mouse CCND2-2989M Recombinant Mouse CCND2 Protein Mammalian Cell His
    Mouse Ccnd2-799M Recombinant Mouse Ccnd2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CCND2-1220R Recombinant Rat CCND2 Protein Mammalian Cell His
    Chicken CCND2-5787C Recombinant Chicken CCND2 Mammalian Cell His

    CCND2 involved in several pathways and played different roles in them. We selected most pathways CCND2 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway BRAF; FOXO1; SOD2; GADD45AB; TGFBR1; HOMER2; G6PCA.2; PLK2B; HRASA; FOXG1A
    p signaling pathway CD82A; CCND3; PIDD1; TNFRSF10B; TRP53; SFN; CYCSB; PERP; CCNE1; GADD45B
    PIK-Akt signaling pathway Ifna15; MTOR; GNG7; GHR; IFNA17; SGK1; IL2RG; VTN; PIK3R3; FGF18
    Wnt signaling pathway PRKCG; LRP5; PRKACAB; PLCB1; SFRP4; DKK2; EP300; PRKACBB; PPP3R1; PPARD
    Hippo signaling pathway TGFBR2; LIMD1; JUB; Fzd4; AXIN2; SMAD1; BMPR2; BMP4; SAV1; FZD7
    Focal adhesion ACTN1; Itga10&Itgb1; ELK1; ACTB2; PDGFRB; COL5A2; ACTN3A; COL27A1B; PAK3; COL11A2
    Jak-STAT signaling pathway IL11RA; IFNPHI3; IL4R; OSM; PIK3CA; PRP2; IL24; IL22; NT5C3; LEPA
    Prolactin signaling pathway SOCS1; PPIB; MAPK12; INS1; MAPK8; PRP2; MAPK1; STAT5B; SHC4; PRL
    HTLV-I infection Fzd4; DVL3; GSK3B; MAP2K4; ANAPC7; PIK3CA; XPO1; PDGFB; SMAD3; POLE
    Transcriptional misregulation in cancer IGF1; TLX1; IGF1R; RUNX1; ERG; RXRG; HIST1H3I; PAX7; MDM2; ETV4
    Viral carcinogenesis GTF2A2; C3; CDC20; TRP53; SRF; HIST1H2BI; PKM; CREB3L2; HDAC9; PRKACB
    MicroRNAs in cancer Abcb1b; SERPINB5; PRKCG; MAP2K2; TGFB2; MARCKS; EFNA3; PIK3CA; NOTCH3; FGFR3

    CCND2 has several biochemical functions, for example, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND2 itself. We selected most functions CCND2 had, and list some proteins which have the same functions with CCND2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MST1R; SPDL1; CSNK1D; CMTM2A; LGALS3; LEMD3; CD200R3; PSMB1; SPATA7; SSR1
    protein kinase binding GCET2; FGF19; PTPN1; JAK2; CCND1; TRAF6; USF1; RPS3; DBF4B; RAD9

    CCND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND2.


    Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
    Khaidakov, M; Mitra, S; et al. Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer. PLOS ONE 6:-(2011).

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