Recombinant Human CCND2 Protein (Full length), N-GST-tagged

• Cat.No.: CCND2-25H
• Product Overview: Recombinant full-length human CyclinD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: Full length
• Description: CyclinD2 is a member of the D-type cyclins. D-type cyclins are regulators of the cell cycle and interact with several transcription factors modulating their transcriptional activations. CyclinD2 forms a complex and functions as a regulatory subunit of CDK4 or CDK6 that regulates the cell-cycle during G1/S transition. These complexes overcome the G1 growth arrest phase by phosphorylating and inactivating the retinoblastoma tumor suppressor protein. CyclinD2 is upregulated in the carcinogenesis of tumors, making it a possible therapeutic target for a variety of cancers, including colon cancer, stomach cancer, liver cancer, breast cancer, and lung cancer.
• Molecular Mass: Observed MW: ~60 kDa.
  Calculated MW: ~59 kDa.
• Purity: The purity of CyclinD2 was determined to be > 85 % by densitometry.
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT and 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: CCND2 cyclin D2 [ Homo sapiens (human) ]
• Official Symbol: CCND2
• Synonyms: CCND2; cyclin D2; G1/S-specific cyclin-D2; G1/S specific cyclin D2; G1/S-specific cyclin D2; KIAK0002; MGC102758
• Gene ID: 894
• mRNA Refseq: NM_001759
• Protein Refseq: NP_001750
• MIM: 123833
• UniProt ID: P30279