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CD226

  • Official Full Name

    CD226 antigen

  • Overview

    DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s
  • Synonyms

    CD226; CD226 antigen; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; DNAM1; DNAM-1; TLiSA1; BC051526;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • Avi
  • Flag
  • GST
  • hIgG4
  • His
  • mFc
  • T7
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD226-636H Active Recombinant Human CD226 Protein, Fc & Avi-tagged, Biotinylated HEK293 Fc&Avi Glu 19 - Asn 247
Human CD226-051H Active Recombinant Human CD226 protein, His/Avi-tagged, Biotinylated HEK293 cells His&Avi Glu19-Asn247
Human CD226-635HP Active Recombinant Human CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc Met1-Asn247
Human CD226-052H Active Recombinant Human CD226 protein, Fc/Avi-tagged, CHO cells Fc&Avi Glu19-Asn247
Human CD226-7254H Recombinant Human CD226, His-tagged E.coli His 19-254aa
Human CD226-635H Recombinant Human CD226 protein, Fc-tagged HEK293 Fc 229
Human CD226-0750H Recombinant Human CD226 Protein, GST-Tagged Wheat Germ GST
Human CD226-1603H Recombinant Human CD226 Molecule Mammalian cells Non
Human CD226-139H Recombinant Human CD226 protein, T7/His-tagged E.coli His&T7 19-254
Human CD226-634H Recombinant Human CD226, Fc-His tagged Human Cell His&Fc Met1-Asn247
Human CD226-229H Recombinant Human CD226 protein, His-tagged HEK293 His Glu19-Asn247
Human CD226-2190H Recombinant Human CD226, His tagged Human Cell His Met1-Asn247
Human CD226-2645HCL Recombinant Human CD226 cell lysate Human Cell Non
Human CD226-634HA Recombinant Human CD226 protein, Fc-His-tagged, APC labeled HEK293 His&Fc
Human CD226-634HAF488 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 His&Fc 477
Human CD226-395H Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated HEK293 His&Fc Met1-Asn247
Human CD226-3056H Recombinant Human CD226 Protein, MYC/DDK-tagged HEK293 Myc&DDK
Human CD226-248HG Active GMP Recombinant Human CD226 protein HEK293 DNA sequence encoding Human DNAM-1(NCBI Reference Sequence: NP_006557.2) was expressed with His tag at the C-terminal.
Human CD226-635HAF488 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 229
Human CD226-2190HB Recombinant Human CD226 protein, His-tagged, Biotinylated HEK293 His Met1-Asn247
Human CD226-634HP Recombinant Human CD226 protein, Fc-His-tagged, R-PE labeled HEK293 His&Fc
Human CD226-5428H Recombinant Human CD226 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human CD226-583H Recombinant Human CD226 Protein (Glu19-Asn247), C-mFc and 6×His-tagged HEK293 His&mFc Glu19-Asn247
Human CD226-2190HAF555 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 240
Human CD226-635HA Recombinant Human CD226 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD226-151H Recombinant Human CD226 Protein, His-tagged Human Cells His
Human CD226-578H Recombinant Human CD226 Protein, His-Avi-tagged HEK293 His&Avi Met1-Asn247
Human CD226-634HAF555 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 His&Fc 477
Human CD226-2190HAF488 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 240
Human CD226-635HAF647 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 229
Human CD226-635HAF555 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 229
Human CD226-2190HAF647 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 240
Human CD226-635HF Recombinant Human CD226 Protein, hFc-tagged, FITC conjugated HEK293 Fc 229
Human CD226-220H Recombinant Human CD226 Protein, C-His-tagged E.coli His
Human CD226-23H Recombinant Human CD226 Protein (ECD), Fc-His-tagged(C-ter) HEK293 His&Fc Glu19-Asn247
Human CD226-634HAF647 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 His&Fc 477
Human CD226-658H Recombinant Human CD226 Protein HEK293 336
Human CD226-1273HFL Recombinant Full Length Human CD226 Protein, C-Flag-tagged Mammalian cells Flag
Human CD226-3924H Recombinant Human CD226 Protein (Met1-Asn247), C-His tagged Mammalian cells His Met1-Asn247
Human CD226-634HF Recombinant Human CD226 Protein, Fc/His-tagged, FITC conjugated HEK293 His&Fc 477
Human CD226-4374H Recombinant Human CD226 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human CD226-01H Recombinant Human CD226 Protein, hIgG-His-Tagged Insect Cell His&Fc 471aa
Human CD226-659H Recombinant Human CD226 Protein, Fc-tagged HEK293 Fc 336
Human CD226-1274H Active Recombinant Human CD226 protein, hFc&His-tagged HEK293 His&Fc Glu19-Asn247
Human CD226-4374H-B Recombinant Human CD226 Protein Pre-coupled Magnetic Beads HEK293
Human CD226-2190HF Recombinant Human CD226 Protein, His-tagged, FITC conjugated HEK293 His 240
Mouse Cd226-635M Recombinant Mouse Cd226, Fc-His tagged Human Cell His&Fc Met1-Pro254
Mouse Cd226-2274M Active Recombinant Mouse Cd226 protein, His-tagged HEK293 His Met1-Pro254
Mouse CD226-2800MCL Recombinant Mouse CD226 cell lysate Human Cell Non
Mouse Cd226-5756M Recombinant Mouse Cd226 Protein (Glu19-Pro254), C-His tagged Mammalian cells His Glu19-Pro254
Mouse Cd226-635MAF647 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 His&Fc 484
Mouse Cd226-2274MF Recombinant Mouse Cd226 Protein, His-tagged, FITC conjugated HEK293 His 247
Mouse Cd226-635MA Recombinant Mouse Cd226 protein, Fc-His-tagged, APC labeled HEK293 His&Fc
Mouse Cd226-635MF Recombinant Mouse Cd226 Protein, Fc/His-tagged, FITC conjugated HEK293 His&Fc 484
Mouse Cd226-635MP Recombinant Mouse Cd226 protein, Fc-His-tagged, R-PE labeled HEK293 His&Fc
Mouse Cd226-2274MAF647 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 247
Mouse Cd226-635MAF488 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 His&Fc 484
Mouse Cd226-635MAF555 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 His&Fc 484
Mouse Cd226-2274MAF555 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 247
Mouse Cd226-2274MAF488 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 247
Mouse Cd226-2056M Recombinant Mouse Cd226 Protein, Myc/DDK-tagged HEK293T Myc&DDK
Rat Cd226-8794R Active Recombinant Rat Cd226 protein, hFc-tagged HEK293 Fc Met1-Ile265
Rat Cd226-1105R Recombinant Rat Cd226 protein(Met1-Ile265), His-tagged HEK293 His Met1-Ile265
Rat CD226-1173RCL Recombinant Rat CD226 cell lysate Human Cell Non
Rat Cd226-8794RAF488 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 475
Rat Cd226-8794RP Recombinant Rat Cd226 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat Cd226-1105RAF555 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 245
Rat Cd226-8794RAF555 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 475
Rat Cd226-1105RAF488 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 245
Rat Cd226-8794RA Recombinant Rat Cd226 protein, Fc-tagged, APC labeled HEK293 Fc
Rat Cd226-1105RAF647 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 245
Rat Cd226-8794RF Recombinant Rat Cd226 Protein, Fc-tagged, FITC conjugated HEK293 Fc 475
Rat Cd226-8794RAF647 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 475
Rat Cd226-1105RF Recombinant Rat Cd226 Protein, His-tagged, FITC conjugated HEK293 His 245
Monkey CD226-248CAF488 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Glu19-Asn247
Monkey CD226-248CAF647 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Glu19-Asn247
Monkey CD226-248CAF555 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Glu19-Asn247
Monkey CD226-248CF Active Recombinant Monkey CD226 Protein, Fc-tagged, FITC conjugated HEK293 Fc Glu19-Asn247
Rhesus monkey CD226-1607R Recombinant Rhesus Monkey CD226 Protein HEK293 Non 19-254
Rhesus monkey CD226-1608R Recombinant Rhesus Monkey CD226 Protein, hIgG1-tagged HEK293 Fc 19-254
Rhesus monkey CD226-1609R Recombinant Rhesus Monkey CD226 Protein, hIgG4-tagged HEK293 hIgG4 19-254
Cynomolgus CD226-248C Active Recombinant Cynomolgus CD226 protein, Fc-tagged HEK293 Fc Glu19-Asn247
Cynomolgus CD226-318C Active Recombinant Cynomolgus CD226 protein(Met1-Phe252), His-tagged HEK293 His Met1-Phe252
Cynomolgus CD226-248CP Recombinant Cynomolgus CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc
Cynomolgus CD226-248CA Recombinant Cynomolgus CD226 protein, Fc-tagged, APC labeled HEK293 Fc
Cynomolgus Monkey CD226-1167CCL Recombinant Cynomolgus CD226 cell lysate Human Cell Non
Macaca mulatta (Rhesus macaque) RFL4722MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Cd226 Antigen(Cd226) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-336)
Rhesus Macaque CD226-729R Recombinant Rhesus monkey CD226 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD226-555R-B Recombinant Rhesus Macaque CD226 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD226-555R Recombinant Rhesus Macaque CD226 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Zebrafish CD226-5128Z Recombinant Zebrafish CD226 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD226 involved in several pathways and played different roles in them. We selected most pathways CD226 participated on our site, such as Adaptive Immune System, Cell adhesion molecules (CAMs), Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD226 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemKIF4;LRSAM1;DYNC1I2;GRAP2A;RNF144B;AKR1C1;B2ML;CTSL2;FBXO17
Cell adhesion molecules (CAMs)ICAM3;ITGA6B;CD274;ITGB1A;CD99;NLGN4X;TIGIT;BLB2;NCAM1
Immune SystemTRAF7;CD160;DEFB103A;TRIM46;IFIT2;PAG1;UBR1;TRIM14;IFI27
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellSIGLEC9;LILRA1;CD226;CD300C;CD300LB;KLRB1A;LILRB2;CD200R1;TREML4

CD226 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD226 itself. We selected most functions CD226 had, and list some proteins which have the same functions with CD226. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingPVRL1B;ITGB7;CAML;PTPRD;ITGB1;ITGAL;LILRB2;PVRL1;CADM2
integrin bindingPXN;S1PR3;ECM2;S1PR2;TIMP2;NISCH;ADAM2;NIPAL1;Npnt
protein bindingATP6V1C1;KLRG1;RCHY1;TLR3;SDC2;CDYL2;BAZ2A;MAPK8;GGNBP2
protein homodimerization activityPDGFA;TRIM9;XBP1;DSCAML1;UPK1A;VEGFA;GTF2A2;DROSHA;ABCD2
protein kinase bindingSKAP1;TELO2;TPRKB;BCAR1;ARHGEF7;PTPRK;SPDYB;PAX6;KIF14
receptor activityLILRB2;MED30;CD46;PAQR3B;MED4;BTN1A1;CADM1A;KLRC4-KLRK1;GUCY1B3

CD226 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD226 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD226.

TIGIT; PVR; PVRL2

Research Area

Related articles

Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
Hou, SK; Ge, KK; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 289:6969-6977(2014).
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