CD226

  • Official Full Name

    CD226 antigen

  • Overview

    DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s
  • Synonyms

    CD226; CD226 antigen; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; DNAM1; DNAM-1; TLiSA1; BC051526;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi|Fc
  • C
  • His
  • mFc
  • 6×His
  • Fc
  • Avi
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hFc
  • HIgG
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|Fc
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD226-636H Active Recombinant Human CD226 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD226-051H Active Recombinant Human CD226 protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi
Human CD226-635HP Active Recombinant Human CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD226-052H Active Recombinant Human CD226 protein, Fc/Avi-tagged, CHO cells Fc/Avi
Human CD226-7254H Recombinant Human CD226, His-tagged E.coli His
Human CD226-635H Recombinant Human CD226 protein, Fc-tagged HEK293 human/IgG1/Fc
Human CD226-0750H Recombinant Human CD226 Protein, GST-Tagged Wheat Germ GST
Human CD226-1603H Recombinant Human CD226 Molecule Mammalian cells N/A
Human CD226-139H Recombinant Human CD226 protein, T7/His-tagged E.coli T7/His
Human CD226-634H Recombinant Human CD226, Fc-His tagged Human Cell Fc/His
Human CD226-229H Recombinant Human CD226 protein, His-tagged HEK293 His
Human CD226-2190H Recombinant Human CD226, His tagged Human Cell His
Human CD226-2645HCL Recombinant Human CD226 cell lysate Human Cell N/A
Human CD226-634HA Recombinant Human CD226 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human CD226-634HAF488 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Human CD226-395H Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated HEK293 His/Fc
Human CD226-3056H Recombinant Human CD226 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD226-248HG Active GMP Recombinant Human CD226 protein HEK293
Human CD226-635HAF488 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
Human CD226-2190HB Recombinant Human CD226 protein, His-tagged, Biotinylated HEK293 His
Human CD226-634HP Recombinant Human CD226 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human CD226-5428H Recombinant Human CD226 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD226-583H Recombinant Human CD226 Protein (Glu19-Asn247), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His
Human CD226-2190HAF555 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human CD226-635HA Recombinant Human CD226 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD226-151H Recombinant Human CD226 Protein, His-tagged Human Cells His
Human CD226-578H Recombinant Human CD226 Protein, His-Avi-tagged HEK293 His-Avi
Human CD226-634HAF555 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Human CD226-2190HAF488 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human CD226-635HAF647 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
Human CD226-635HAF555 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
Human CD226-2190HAF647 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human CD226-635HF Recombinant Human CD226 Protein, hFc-tagged, FITC conjugated HEK293 hFc
Human CD226-220H Recombinant Human CD226 Protein, C-His-tagged E.coli C-His
Human CD226-23H Recombinant Human CD226 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human CD226-634HAF647 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Human CD226-658H Recombinant Human CD226 Protein HEK293
Human CD226-1273HFL Recombinant Full Length Human CD226 Protein, C-Flag-tagged Mammalian cells Flag
Human CD226-3924H Recombinant Human CD226 Protein (Met1-Asn247), C-His tagged Mammalian cells C-His
Human CD226-634HF Recombinant Human CD226 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Human CD226-4374H Recombinant Human CD226 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD226-01H Recombinant Human CD226 Protein, hIgG-His-Tagged Insect Cell HIgG/His
Human CD226-659H Recombinant Human CD226 Protein, Fc-tagged HEK293 Fc
Human CD226-1274H Active Recombinant Human CD226 protein, hFc&His-tagged HEK293 hFc&His
Human CD226-4374H-B Recombinant Human CD226 Protein Pre-coupled Magnetic Beads HEK293
Human CD226-2190HF Recombinant Human CD226 Protein, His-tagged, FITC conjugated HEK293 His
Mouse Cd226-635M Recombinant Mouse Cd226, Fc-His tagged Human Cell Fc/His
Mouse Cd226-2274M Active Recombinant Mouse Cd226 protein, His-tagged HEK293 His
Mouse CD226-2800MCL Recombinant Mouse CD226 cell lysate Human Cell N/A
Mouse Cd226-5756M Recombinant Mouse Cd226 Protein (Glu19-Pro254), C-His tagged Mammalian cells C-His
Mouse Cd226-635MAF647 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Mouse Cd226-2274MF Recombinant Mouse Cd226 Protein, His-tagged, FITC conjugated HEK293 His
Mouse Cd226-635MA Recombinant Mouse Cd226 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Mouse Cd226-635MF Recombinant Mouse Cd226 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Mouse Cd226-635MP Recombinant Mouse Cd226 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Mouse Cd226-2274MAF647 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Mouse Cd226-635MAF488 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Mouse Cd226-635MAF555 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Mouse Cd226-2274MAF555 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Mouse Cd226-2274MAF488 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Mouse Cd226-2056M Recombinant Mouse Cd226 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Cd226-8794R Active Recombinant Rat Cd226 protein, hFc-tagged HEK293 hFc
Rat Cd226-1105R Recombinant Rat Cd226 Protein, His-tagged HEK293 His
Rat CD226-1173RCL Recombinant Rat CD226 cell lysate Human Cell N/A
Rat Cd226-8794RAF488 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat Cd226-8794RP Recombinant Rat Cd226 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat Cd226-1105RAF555 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat Cd226-8794RAF555 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rat Cd226-1105RAF488 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rat Cd226-8794RA Recombinant Rat Cd226 protein, Fc-tagged, APC labeled HEK293 Fc
Rat Cd226-1105RAF647 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Rat Cd226-8794RF Recombinant Rat Cd226 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat Cd226-8794RAF647 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat Cd226-1105RF Recombinant Rat Cd226 Protein, His-tagged, FITC conjugated HEK293 His
Monkey CD226-248CAF488 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Monkey CD226-248CAF647 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Monkey CD226-248CAF555 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Monkey CD226-248CF Active Recombinant Monkey CD226 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rhesus monkey CD226-1607R Recombinant Rhesus Monkey CD226 Protein HEK293 N/A
Rhesus monkey CD226-1608R Recombinant Rhesus Monkey CD226 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey CD226-1609R Recombinant Rhesus Monkey CD226 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus CD226-248C Active Recombinant Cynomolgus CD226 protein, Fc-tagged HEK293 Fc
Cynomolgus CD226-318C Active Recombinant Cynomolgus CD226 protein(Met1-Phe252), His-tagged HEK293 C-His
Cynomolgus CD226-248CP Recombinant Cynomolgus CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc
Cynomolgus CD226-248CA Recombinant Cynomolgus CD226 protein, Fc-tagged, APC labeled HEK293 Fc
Cynomolgus Monkey CD226-1167CCL Recombinant Cynomolgus CD226 cell lysate Human Cell N/A
Macaca mulatta (Rhesus macaque) RFL4722MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Cd226 Antigen(Cd226) Protein, His-Tagged E.coli expression system His
Rhesus Macaque CD226-729R Recombinant Rhesus monkey CD226 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD226-555R-B Recombinant Rhesus Macaque CD226 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD226-555R Recombinant Rhesus Macaque CD226 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CD226-5128Z Recombinant Zebrafish CD226 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD226 Related Articles
  • CD226 Related Research Area

CD226 involved in several pathways and played different roles in them. We selected most pathways CD226 participated on our site, such as Adaptive Immune System, Cell adhesion molecules (CAMs), Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD226 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemIGLC2;MKRN1;DZIP3;RNF34;LILRB4;AP1S3A;KIF11;KLC3;IGHM
Cell adhesion molecules (CAMs)NCAM2;JAM3;ITGB2L;NLGN3A;ITGAL;SELPLG;NRXN3A;NTNG1;H2-AA
Immune SystemBTR22;RACGAP1;DEFA5;BLMH;STIM1B;EDAR;POLR3H;BTR18;CD226
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTREML4;SIGLEC10;CD300LD;CD200R2;TREML2;CD300E;MICA;SIGLEC11;LAIR2

CD226 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD226 itself. We selected most functions CD226 had, and list some proteins which have the same functions with CD226. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingCD200;PVRL1B;ITGB7;NRXN2;DSP;LILRB2;NCR3;PVRL1;PVRL1A
integrin bindingCOL5A1;CYR61;IGF1;CXADR;THY1;AMICA1;TGFBI;COL3A1;ESM1
protein bindingCOX5A;CD300LH;FSTL3;BMPR1AA;KIAA0141;HGS;SLC6A20;RPL5;TXNL4B
protein homodimerization activityZFP365;IRF3;ENG;CHMP4C;IL6R;SETMAR;HM13;CHMP1A;GGCT
protein kinase bindingPLK1;PPP1R12B;USF1;GCSAM;PRKAG3;IKBKB;ARHGEF7;STXBP1;PTPRC
receptor activityTIGIT;ANXA2R;CD160;NCR3;TLR2;GRIA3B;NOTCH4;TREM2;HTR3A

CD226 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD226 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD226.

TIGIT; PVR; PVRL2

Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
Hou, SK; Ge, KK; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 289:6969-6977(2014).
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