cd226

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cd226

Official Full Name CD226 antigen
Background DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s
Synonyms CD226; CD226 antigen; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; DNAM1; DNAM-1; TLiSA1; BC051526
    • Species :
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NSO
    • Wheat Germ
    • Tag :
    • Avi
    • Fc
    • His
    • GST
    • hIgG1
    • hIgG4
    • human
    • IgG1
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus CD226-248CA Recombinant Cynomolgus CD226 protein, Fc-tagged, APC labeled HEK293 Fc
    Cynomolgus CD226-248CP Recombinant Cynomolgus CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Cynomolgus CD226-318C Recombinant Cynomolgus CD226 protein, His-tagged HEK293 His
    Human CD226-395H Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Human CD226-634HA Recombinant Human CD226 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
    Human CD226-634HP Recombinant Human CD226 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
    Human CD226-635HA Recombinant Human CD226 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD226-635HP Recombinant Human CD226 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Mouse Cd226-635MA Recombinant Mouse Cd226 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
    Mouse Cd226-635MP Recombinant Mouse Cd226 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
    Rat Cd226-8794RA Recombinant Rat Cd226 protein, Fc-tagged, APC labeled HEK293 Fc
    Rat Cd226-8794RP Recombinant Rat Cd226 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD226-0750H Recombinant Human CD226 Protein, GST-Tagged Wheat Germ GST
    Human CD226-139H Recombinant Human CD226 protein, T7/His-tagged E.coli T7/His
    Human CD226-1603H Recombinant Human CD226 Molecule NSO N/A
    Human CD226-2190H Recombinant Human CD226, His tagged Human Cell His
    Human CD226-229H Recombinant Human CD226 protein, His-tagged HEK293 His
    Human CD226-2645HCL Recombinant Human CD226 cell lysate Human Cell N/A
    Human CD226-3056H Recombinant Human CD226 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD226-634H Recombinant Human CD226, Fc-His tagged Human Cell Fc/His
    Human CD226-635H Recombinant Human CD226 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD226-636H Recombinant Human CD226 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human CD226-7254H Recombinant Human CD226, His-tagged E.coli His
    Mouse Cd226-2274M Recombinant Mouse Cd226, His tagged Human Cell His
    Mouse CD226-2800MCL Recombinant Mouse CD226 cell lysate Human Cell N/A
    Mouse Cd226-635M Recombinant Mouse Cd226, Fc-His tagged Human Cell Fc/His
    Rat Cd226-1105R Recombinant Rat Cd226 Protein, His-tagged HEK293 His
    Rat CD226-1173RCL Recombinant Rat CD226 cell lysate Human Cell N/A
    Rat Cd226-8794R Recombinant Rat Cd226, Fc tagged Human Cell Fc
    Cynomolgus Monkey CD226-1167CCL Recombinant Cynomolgus CD226 cell lysate Human Cell N/A
    Cynomolgus CD226-248C Recombinant Cynomolgus CD226 protein, Fc-tagged HEK293 Fc
    Rhesus monkey CD226-1607R Recombinant Rhesus Monkey CD226 Protein HEK293 N/A
    Rhesus monkey CD226-1608R Recombinant Rhesus Monkey CD226 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey CD226-1609R Recombinant Rhesus Monkey CD226 Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque CD226-729R Recombinant Rhesus monkey CD226 Protein, His-tagged Mammalian Cell His
    Zebrafish CD226-5128Z Recombinant Zebrafish CD226 Mammalian Cell His

    cd226 involved in several pathways and played different roles in them. We selected most pathways cd226 participated on our site, such as Adaptive Immune System, Cell adhesion molecules (CAMs), Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd226 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CTSO; SH2D1B; RAET1E; FBXO27; B2ML; ASB3; DZIP3; AP2B1; AGO1; UBR2
    Cell adhesion molecules (CAMs) NTNG1; MHC1UEA; HLA-E; CNTNAP2A; VCAM1; CLDN20; CNTN1A; ITGA6B; Icosl; CLDN6
    Immune System CTSLL; LILRA3; ASB13; TRIM38; CTSC; CTS7; CASP2; RNF6; BLMH; DYNC1I2
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD300LG; CD160; CD96; CD200R1; SIGLEC12; AMICA1; CD300LB; LAIR2; LILRB4; Mill2

    cd226 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd226 itself. We selected most functions cd226 had, and list some proteins which have the same functions with cd226. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding PVRL1; LPHN1; PVRL3; CDH1; DSP; POSTN; JUP; CADM2; NLGN2; PVRL2L
    integrin binding L1CAM; PXN; TNN; NOV; ADAMTS8; COL16A1; NISCH; ADAM25; LAMB2; CTGFA
    protein binding MVP; HSF1; SERPINB1A; CD200R1; TOP1; ASIC2; ITGA6; PCP4; EMP2; EYA1
    protein homodimerization activity TENM1; TREX1; PDCD6IP; FGFR1OP2; GNPTG; PVRL1; ADD1; APOE; HELT; DHDPSL
    protein kinase binding KCNQ3; DVL1; LSM2; ZC3HC1; MEF2A; NPR1; CAMK2N2; TNIP2; ILK; GOLGA2
    receptor activity NR2C1; CADM1B; KLRB1F; LILRA3; ADIPOR1B; GFRA1A; NLGN1; ERBB3B; CUL5; SLC20A1

    cd226 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd226 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd226.

    TIGIT; PVR; PVRL2

    Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
    Hou, SK; Ge, KK; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 289:6969-6977(2014).

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