CD2AP

  • Official Full Name

    CD2-associated protein

  • Overview

    This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
  • Synonyms

    CD2AP; CD2-associated protein; CMS; adapter protein CMS; cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD2AP-538H Recombinant Human CD2AP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD2AP-3053H Recombinant Human CD2AP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD2AP-538H-B Recombinant Human CD2AP Protein Pre-coupled Magnetic Beads HEK293
Human CD2AP-1826H Recombinant Human CD2AP protein, His & T7-tagged E.coli His/T7 Thr149~Glu429 (Accession # Q9Y5K6)
Human CD2AP-151H Recombinant Human CD2AP Protein, His-tagged Human Cells His
Human CD2AP-176H Recombinant Human CD2AP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CD2AP-1802HFL Recombinant Full Length Human CD2AP Protein, C-Flag-tagged Mammalian cells Flag
Human CD2AP-0933H Recombinant Human CD2AP Protein (Thr149-Glu429), N-His tagged E.coli N-His Thr149-Glu429
Mouse CD2AP-3069M Recombinant Mouse CD2AP Protein Mammalian Cell His
Mouse CD2AP-1449M-B Recombinant Mouse CD2AP Protein Pre-coupled Magnetic Beads HEK293
Mouse CD2AP-1449M Recombinant Mouse CD2AP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cd2ap-1827R Recombinant Rat Cd2ap protein, His & T7-tagged E.coli His/T7 Asp368~Leu623 (Accession # Q80ZE7)
Rhesus Macaque CD2AP-734R Recombinant Rhesus monkey CD2AP Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD2AP-560R-B Recombinant Rhesus Macaque CD2AP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD2AP-560R Recombinant Rhesus Macaque CD2AP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CD2AP-1881Z Recombinant Zebrafish CD2AP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD2AP involved in several pathways and played different roles in them. We selected most pathways CD2AP participated on our site, such as Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD2AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bacterial invasion of epithelial cellsCTNNA2;PIK3CB;MAD2L2;WASF2;PIK3R5;PIK3CA;CAV2;RHOA;SHC1

CD2AP has several biochemical functions, for example, SH3 domain binding, beta-catenin binding, cadherin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD2AP itself. We selected most functions CD2AP had, and list some proteins which have the same functions with CD2AP. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingSH3BP2;SHANK2;WAS;INPP5J;SH3BGRL;OSTF1;CABYR;FAM125A;FUT8
beta-catenin bindingTCF7;PARK2;SLC9A3R2;PTPRK;CTNNBIP1;CTNNA1;RORA;LEF1;CD2AP
cadherin bindingOLFM4;NEO1;JUP;GNA13A;Fert2;CTNNA1;MMP24;CD2AP;PROM1
protein C-terminus bindingPIAS4;PQBP1;TAE1;PPP2CA;PRKAA1;PEX5;NPAT;DAB2;ATP1B1
protein bindingPELI1;FRS2;HMGA1;EFCAB4A;TRAM1;C1orf216;NUP50;CARD9;KCNE1L
protein complex bindingNDUFA9;HCLS1;EPHB1;THRA;BCAP31;AP2B1;CALY;VDAC1;STK11
vascular endothelial growth factor receptor bindingFIGF;CD2AP;VEGFA

CD2AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD2AP here. Most of them are supplied by our site. Hope this information will be useful for your research of CD2AP.

Rab4a; CAPZA2; KIF23; SH3D19; SHCBP1; SH3KBP1; RACGAP1; KCTD10; b4dg94_human; ARAP1; CLTC

Research Area

Related articles

Kimura, J; Ichii, O; et al. Close Relations between Podocyte Injuries and Membranous Proliferative Glomerulonephritis in Autoimmune Murine Models. AMERICAN JOURNAL OF NEPHROLOGY 38:27-38(2013).
Tomasini, D; Mentzel, T; et al. Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus. JOURNAL OF CUTANEOUS PATHOLOGY 37:1132-1139(2010).
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