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Recombinant Human CD2AP protein, His & T7-tagged

Cat.No. : CD2AP-1826H
Product Overview : Recombinant Human CD2AP aa. (Thr149~Glu429 (Accession # Q9Y5K6)) fused with N-terminal His & T7 tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Description : This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : 44kDa as determined by SDS-PAGE reducing conditions.
Protein length : Thr149~Glu429 (Accession # Q9Y5K6)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 7.8
Gene Name : CD2AP CD2 associated protein [ Homo sapiens (human) ]
Official Symbol : CD2AP
Synonyms : CD2AP; CD2 associated protein; CMS; CD2-associated protein; Cas ligand with multiple Src homology 3 (SH3) domains; adapter protein CMS; cas ligand with multiple SH3 domains
Gene ID : 23607
mRNA Refseq : NM_012120.2
Protein Refseq : NP_036252.1
UniProt ID : Q9Y5K6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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