Recombinant Full Length Human CD2AP Protein, C-Flag-tagged

• Cat.No.: CD2AP-1802HFL
• Product Overview: Recombinant Full Length Human CD2AP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71.3 kDa
• AA Sequence: MVDYIVEYDYDAVHDDELTIRVGEI IRNVKKLQEEGWLEGELNGRRGMFP DNFVKEIKRETEFKDDSLPI KRERHGNVASLVQRISTYGLPAGGI QPHPQTKNIKKKTKKRQCKVLFEYI PQNEDELELKVGDIIDINEE VEEGWWSGTLNNKLGLFPSNFVKEL EVTDDGETHEAQDDSETVLAGPTSP IPSLGNVSETASGSVTQPKK IRGIGFGDIFKEGSVKLRTRTSSSE TEEKKPEKPLILQSLGPKTQSVEIT KTDTEGKIKAKEYCRTLFAY EGTNEDELTFKEGEIIHLISKETGE AGWWRGELNGKEGVFPDNFAVQINE LDKDFPKPKKPPPPAKAPAP KPELIAAEKKYFSLKPEEKDEKSTL EQKPSKPAAPQVPPKKPTPPTKASN LLRSSGTVYPKRPEKPVPPP PPIAKINGEVSSISSKFETEPVSKL KLDSEQLPLRPKSVDFDSLTVRTSK ETDVVNFDDIASSENLLHLT ANRPKMPGRRLPGRFNGGHSPTHSP EKILKLPKEEDSANLKPSELKKDTC YSPKPSVYLSTPSSASKANT TAFLTPLEIKAKVETDDVKKNSLDE LRAQIIELLCIVEALKKDHGKELEK LRKDLEEEKTMRSNLEMEIE KLKKAVLSS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: CD2AP CD2 associated protein [ Homo sapiens (human) ]
• Official Symbol: CD2AP
• Synonyms: CMS
• Gene ID: 23607
• mRNA Refseq: NM_012120.3
• Protein Refseq: NP_036252.1
• MIM: 604241
• UniProt ID: Q9Y5K6