cdh1
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  • Official Full Name
  • cadherin 1, type 1, E-cadherin (epithelial)
  • Background
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
  • Synonyms
  • CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; Arc1; CADH1_HUMAN; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CD 234; CD324 antigen; E-Cad/CTF3; epithelial calcium dependant adhesion protein; Liver cell adhesion molecule
Cat.#:CDH1-0969HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH1 Protein, GST-Tagged
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Cat.#:CDH1-3118HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1 Protein, MYC/DDK-tagged
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Cat.#:Cdh1-1719MTag:
Source (Host):NSOSpecies:Mouse
Product nameRecombinant Mouse Cdh1 Protein
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Cat.#:CDH1-1605HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial)
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Cat.#:CDH1-198HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDH1 Protein, His-tagged
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Cat.#:CDH1-26935THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH1
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Cat.#:CDH1-274HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1, Fc tagged
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Cat.#:CDH1-275HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1 protein, Fc-tagged
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Cat.#:CDH1-278HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1, StrepII-tagged
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Cat.#:CDH1-43HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CDH1 Protein, His-tagged
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Cat.#:CDH1-548HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human CDH1 Protein, Fc Chimera
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Cat.#:CDH1-579HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH1 protein, His & S-tagged
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Cat.#:CDH1-689HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1, His tagged
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Cat.#:CDH1-691HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1 protein, His-tagged
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Cat.#:CDH1-86HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cadherin 1, Type 1, E-cadherin (Epithelial)
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Cat.#:Cdh1-4070MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cdh1, His tagged
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Cat.#:Cdh1-580MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh1 protein, His-tagged
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Cat.#:Cdh1-581MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh1 protein, His-tagged
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Cat.#:CDH1-1288RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDH1 Protein
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Cat.#:Cdh1-549RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cdh1, His-tagged
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Cat.#:Cdh1-583RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdh1 protein, His-tagged
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Cat.#:Cdh1-584RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdh1 protein, His & S-tagged
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Cat.#:Cdh1-7-7477RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cdh1, His tagged
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Cat.#:Cdh1-8756RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cdh1, Fc tagged
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Cat.#:CDH1-1737RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH1 Protein
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Cat.#:CDH1-1738RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH1 Protein, hIgG1-tagged
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Cat.#:CDH1-1739RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH1 Protein, hIgG4-tagged
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Cat.#:CDH1-3324CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDH1
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Cat.#:CDH1-578CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CDH1 protein, His-tagged
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Cat.#:CDH1-9331ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDH1
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Cat.#:CDH1-582PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CDH1 protein, His & GST-tagged
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Cat.#:CDH1-938HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH1 cell lysate
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Cat.#:CDH1-1892MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CDH1 cell lysate
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Cat.#:CDH1-736RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CDH1 cell lysate
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Involved Pathway

CDH1 involved in several pathways and played different roles in them. We selected most pathways CDH1 participated on our site, such as Rap signaling pathway, Hippo signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
LPAR2; AKT1; ITGB2; ITGA2B; SKAP1; FGF7; FGF9; RAPGEF6; FGF12; CDH1
Hippo signaling pathway
SMAD4; WNT6; BMP8B; SERPINE1; ITGB2L; BTRC; PPP2CB; DVL3; FZD7; PPP2R2C
Cell adhesion molecules (CAMs)
F11R.1; CTLA4; NLGN2A; NEO1A; GLYCAM1; CLDN23; ITGAV; CADM1A; NTNG1; HLA-DRB4
Adherens junction
RHOAC; CSNK2B; CSNK2A1; ACTN4; WASLB; CREBBP; TGFBR2; SMAD4; NLK; ACTB
Bacterial invasion of epithelial cells
SHC3; PIK3CB; DNM2; WASL; SEPT1; ARPC4; ARPC3; DNM1; VCL; CAV1
Pathogenic Escherichia coli infection
ROCK1; CDH1; TUBA3D; TUBB6; CD14; ITGB1; ACTB; HCLS1; TUBB1; TUBB2A
Pathways in cancer
GNG5; VEGFB; F2RL3; SMAD3; TRAF5; SMAD4; BRCA2; RXRA; DAPK1; GNG13
Endometrial cancer
MAPK1; PIK3CA; CDH1; ILK; CTNNA3; CCND1; ARAF; AXIN1; TCF7; PIK3CG
Thyroid cancer
TCF7; RXRA; BRAF; TP53; NCOA4; MAP2K2; LEF1; PPARG; MAPK3; MAP2K1
Melanoma
AKT2; FGF6; FGF5; HRAS; FGF18; FGF13; FGF14; TRP53; BRAF; FGF2
Bladder cancer
MMP9; RAF1; IL-8; DAPK2; CDKN2A; DAPK1; MAP2K2; UPK3A; TYMP; CCND1

Protein Function

CDH1 has several biochemical functions, for example, GTPase activating protein binding, ankyrin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH1 itself. We selected most functions CDH1 had, and list some proteins which have the same functions with CDH1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activating protein binding
Related Protein GNAI1; MEX3B; TUBB; GNAI3; RGS14; TSC1; PIN1; PLCD1; GAPVD1; GNAO1
Function ankyrin binding
Related Protein KCNQ2; FLNC; RHBG; RHCG; RHAG; KCTD6; SCN5A; PTBP3; SLC8A1; SPTBN1
Function beta-catenin binding
Related Protein APC2; CDH2; DACT2; SOX17; AXIN2; PSEN1; C; TCF7; NF2; TCF7L1B
Function calcium ion binding
Related Protein PVALB7; TTN; CGREF1; SLIT1A; NKD1; SYT1A; EHD1B; BGLAP2; MMP10; PKD1L3
Function cell adhesion molecule binding
Related Protein CADM3; PVRL2L; CD1D; CAML; NLGN2; ITGB3; CD226; POSTN; LILRB2; CDH1
Function gamma-catenin binding
Related Protein DSG1; PTPRK; CDH1; FER; PTPRJ; CDH2; TCF7L2; PTBP3; LEF1; Fert2
Function glycoprotein binding
Related Protein DNAJC5; TFRC; LACRT; FOXRED2; VWF; CALR; SDCBP; CDH1; PIP; TFR2
Function protein binding
Related Protein IGF2R; DESI1; EYA3; KIR2DL3; PTPN22; TMCO6; CELSR1; CDC25B; TP53; SPSB1

Interacting Protein

CDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH1.
CTNNB1; EGFR; Cbll1

CDH1 Related Articles

Waldum, HL; Ringnes, E; et al. The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 49:974-978(2014).
Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).