cdkn2a
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  • Official Full Name
  • cyclin-dependent kinase inhibitor 2A
  • Background
  • The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene(isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.
  • Synonyms
  • CDKN2A; cyclin-dependent kinase inhibitor 2A; Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a); cyclin-dependent kinase inhibitor 2A, isoform 3; CDK4I; p16-INK4; p16-INK4a; mitochondrial smARF; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4);
Cat.#:CDKN2A-1060HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDKN2A Protein, GST-Tagged
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Cat.#:CDKN2A-10HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase Inhibitor 2A
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Cat.#:CDKN2A-117HTag:13-residue TAT
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2A Protein, 13-residue TAT-tagged
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Cat.#:CDKN2A-27912THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2A
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Cat.#:CDKN2A-655HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2A
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Cat.#:CDKN2A-7704HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2A protein, His & T7-tagged
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Cat.#:CDKN2A-3223MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDKN2A Protein
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Cat.#:Cdkn2a-7705MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdkn2a protein, His & T7-tagged
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Cat.#:CDKN2A-1313RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDKN2A Protein
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Cat.#:Cdkn2a-7706RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdkn2a protein, His & T7-tagged
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Cat.#:CDKN2A-6004CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDKN2A
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Cat.#:CDKN2A-7616HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDKN2A 293 Cell Lysate
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Involved Pathway

CDKN2A involved in several pathways and played different roles in them. We selected most pathways CDKN2A participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
IL1B2; TRP53; PANK1A; CASP6L2; PIK3CB; PIK3R3; BID; PPP3CA; MYD88; MAP3K14
Apoptosis Modulation and Signaling
BCL2L11; BLK; HRK; DAXX; HN1; SEPT4; PTRH2; BCL2L10; BOK; CASP2
Bladder cancer
CDH1; CCND1; TRP53; NRAS; CXCL8; MMP2; IL-8; MAP2K2; DAPK1; THBS1
Cell Cycle
RCC2; CENPL; NCAPD3; RBBP7; GINS1; GORASP1; NDEL1B; ENSAB; DYNC1I2; OFD1
Cell Cycle, Mitotic
CLIP1; TSGA14; E2F3; NCAPH; SSNA1; SGOL2; HIST3H2BB; DPF1; CDKN2A; ARPP19
Cellular Senescence
RNF2; HIST3H2BB; RBBP4; CBX4; CBX6A; H1F0; HMGA1-RS1; TNIK; MOV10; PHC1
Cellular responses to stress
CDK6; UBN1; TXN; RBBP4; AMBRA1; CBX8B; PRDX3; RING1; RB1CC1; BMI1B

Protein Function

CDKN2A has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NF-kappaB binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2A itself. We selected most functions CDKN2A had, and list some proteins which have the same functions with CDKN2A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PAX6B; FOXD1; HIST3H2A; GTF2F2; KDM5D; DLX2B; PAX6; RBM6; DHX9; HNRPDL
Function MDM2/MDM4 family protein binding
Related Protein TRP53; CAV1; CDKN2A; CDK5RAP3; RFWD3; PSME3; PPARA
Function NF-kappaB binding
Related Protein PSMA6; EP300; RNF25; HDAC3; ANKRD42; COMMD6; AP1S2; HIF1AN; TAF4B; RELA
Function cyclin-dependent protein serine/threonine kinase inhibitor activity
Related Protein KAT2B; HEXIM2; CDKN1A; CDKN2B; CDKN1C; CDKN2A; CDKN1BB; HEXIM1; CDKN1B; CDKN1D
Function p53 binding
Related Protein CDKN2A; TP53RK; MDM2; GSK3B; TP53BP1; BRD7; HTT; BLM; ZNF385C; DUSP26
Function poly(A) RNA binding
Related Protein SUGP2; WDR6; NSUN5; THOC4; PEF1; NCOA5; TMEM38A; SNRNP70; RBMS1; CROP
Function protein binding
Related Protein PVRL4; SEPT3; POLM; SOCS2; CDK18; TUBGCP4; CAND2; MYOM1; SLC3A2; F7
Function protein kinase binding
Related Protein CAMK2N2; PARN; SHC1; THY1; FZD5; CDKN2D; NPR1; EMP2; BAD; TBC1D14
Function transcription factor binding
Related Protein RBPJ; CD34; PARD6A; SMARCD3; PIM1; RARA; MSX2; NKX2-5; HMGA1-RS1; UBA2
Function ubiquitin-protein transferase inhibitor activity
Related Protein GLMN; CDKN2A

Interacting Protein

CDKN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2A.
CDK4; CDK6

CDKN2A Related Articles

Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).
Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).