CENPE
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Official Full Name
centromere protein E, 312kDa -
Overview
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008] -
Synonyms
CENPE;centromere protein E, 312kDa;KIF10;CENP-E;PPP1R61;centromere-associated protein E;kinesin family member 10;kinesin-related protein CENPE;Centromere autoantigen E (312kD);protein phosphatase 1, regulatory subunit 61
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CENPE-3800H | Recombinant Human CENPE protein, His-tagged | E.coli | Human | His | 2401-2500 aa | |
| CENPE-1114H | Recombinant Human CENPE Protein, GST-Tagged | Wheat Germ | Human | GST |
|
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| CENPE-348H | Recombinant Human CENPE Protein, His-tagged | E.coli | Human | His | Ala2450~Arg2590 |
|
| Cenpe-349R | Recombinant Rat Cenpe Protein, His-tagged | E.coli | Rat | His | Ala2222~Arg2361 |
|
| CENPE-4563Z | Recombinant Zebrafish CENPE | Mammalian Cells | Zebrafish | His |
|
Involved Pathway
CENPE involved in several pathways and played different roles in them. We selected most pathways CENPE participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | GATA5,SH2B3,AKAP1,DGKB,SERPINB8,LOC100514666,FN1B,TRPC6A,PLEK,CD84 |
| Kinesins | KIF2C,KIF20A,KIF3B,KLC3,KIF9,KIF18A,KIFC1,KIF4A,KIF2A,KIF26A |
| Mitotic Anaphase | KNTC1,CLIP1,CENPI,B9D2,ZW10,ERCC6L,CENPQ,CDCA5,NUF2,ITGB3BP |
| Cell cycle | CCNE2,YWHAQB,SYCE1,KNTC1,DCTN3,YWHAE1,YWHABA,NEK2,DHFR,CEP164 |
| M Phase | TMEM188,SETA,PDS5A,CENPA,MIS12,NEK7,CENPC1,NUDC,VRK1,NIPBL |
| Cell Cycle, Mitotic | RCC2,ENSAB,ESCO2,CENPK,INCENP,POLD3,APITD1,CDCA5,CEP290,HIST3H2BB |
| Factors involved in megakaryocyte development and platelet production | BA2,DOCK1,GATA1A,VPS45,KIF18A,KIF2B,DOCK11,HBE1,HBD,HBG2 |
| Mitotic Metaphase and Anaphase | WAPAL,PDS5A,DSN1,NUF2,RCC2,NDEL1B,CENPK,NSL1,PANE1,ITGB3BP |
Protein Function
CENPE has several biochemical functions, for example, ATP binding,ATPase activity,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPE itself. We selected most functions CENPE had, and list some proteins which have the same functions with CENPE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CHD8,PPP1CA,NSFA,PAK1,RPS6KAL,MAP4K6,IQCA1,ACVR2AA,ATP1A3,BMPR1BB |
| microtubule binding | NDEL1,KIF3A,CCDC88A,MTAP1A,KIF23,KIF22,EZR,KIF5B,KIF18A,PAFAH1B1 |
| nucleotide binding | RHOGD,SMYHC2,ARL4CA,PIP5K2,MAPK12A,CSNK1G2B,CPEB1A,DCLK1A,SEPT4A,EEF1A1L1 |
| ATPase activity | KIF4,ABCF2A,ABCC1,ABCC5,HSPA1B,KIF7,KIF2A,ABCD3B,ABCA13,VPS4B |
| microtubule motor activity | KIF5C,KIF13B,DYNC1I1,KIF4A,DYNC1LI2,KIF4,KIF1B,KIF25,APPBP2,DNAH6 |
Interacting Protein
CENPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPE here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPE.
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