CENPE

  • Official Full Name

    centromere protein E, 312kDa
  • Overview

    Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]
  • Synonyms

    CENPE;centromere protein E, 312kDa;KIF10;CENP-E;PPP1R61;centromere-associated protein E;kinesin family member 10;kinesin-related protein CENPE;Centromere autoantigen E (312kD);protein phosphatase 1, regulatory subunit 61
Cat.# Product name Source (Host) Species Tag Protein Length Price
CENPE-3800H Recombinant Human CENPE protein, His-tagged E.coli Human His 2401-2500 aa
CENPE-1114H Recombinant Human CENPE Protein, GST-Tagged Wheat Germ Human GST
CENPE-348H Recombinant Human CENPE Protein, His-tagged E.coli Human His Ala2450~Arg2590
Cenpe-349R Recombinant Rat Cenpe Protein, His-tagged E.coli Rat His Ala2222~Arg2361
CENPE-4563Z Recombinant Zebrafish CENPE Mammalian Cells Zebrafish His

    Involved Pathway

    CENPE involved in several pathways and played different roles in them. We selected most pathways CENPE participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitotic Metaphase and Anaphase CENPQ,PMF1,AHCTF1,NUDC,CDCA8,CENPH,PANE1,WAPAL,SGOL2,NUF2
    Kinesins KIF26A,KIF4A,KLC3,KIF4,KIF2C,KIF22,KIF3B,KIFAP3,KIF2B,KIFC1
    Hemostasis DOCK10,SLC7A6,APOA1B,GAS6,MMRN2A,GATA2A,CAP1,RACGAP1,AASS,STXBP3
    Factors involved in megakaryocyte development and platelet production KIF2A,DOCK6,AKAP10,KIF9,KIF15,OSTN,IRF1B,HBG1,MAFGA,MFN2
    Mitotic Anaphase VRK2,AHCTF1,CENPN,MIS12,SGOL2,SKA2,PDS5A,SPC25,TMPO,LEMD3
    Cell cycle YWHAZ,ENSA,STAG2A,FOXM1,CDH1-A,TRP53,ERCC6L,BABAM1,MYBL2,MSH5
    Cell Cycle, Mitotic SGOL2,RCC2,CDK4,ARPP19,AURKB,APITD1,CLASP1A,SPDL1,DYRK1A,VRK1
    M Phase CENPQ,AHCTF1,DSN1,ENSAA,NDEL1A,SETB,CENPP,LEMD3,NEK7,ZWILCH

    Protein Function

    CENPE has several biochemical functions, for example, ATP binding,ATPase activity,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPE itself. We selected most functions CENPE had, and list some proteins which have the same functions with CENPE. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP2K3,WARS2,RTEL1,ACACA,NTRK3,UBE2C,ATM,KIF6,ACVR1C,PRKG2
    ATPase activity ATAD1,MLH1,ABCC5,ABCG3,OLA1,ATAD2,KIF12,CLPX,PSMC1,ABCF1
    microtubule motor activity BBS4,APPBP2,SMC1A,DYNC1I1,DNALI1,KIF21A,KIF1B,KIF2B,KIF4,KIF20A
    nucleotide binding U2AF1,ARL4AA,CRCP,RBMX,UBE1Y1,MKNK2A,RHOBTB2A,SMYHC2,ABCB1A,PTBP1
    microtubule binding DPYSL5B,SKA1,WHAMM,CHP1,CEP57L1,VAPB,KIF18A,KIF11,KIF20A,CKAP5

    Interacting Protein

    CENPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPE here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPE.

    Resources

    References

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