CLOCK
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Official Full Name
circadian locomotor output cycles kaput
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Overview
Circadian rhythms govern many key physiological processes that fluctuate with a period of approximately 24 hours. These processes include the sleep-wake cycle, glucose, lipid and drug metabolism, heart rate, hormone secretion, renal blood flow, and body t -
Synonyms
CLOCK; circadian locomotor output cycles kaput; circadian locomoter output cycles protein kaput; mCLOCK; circadian locomoter output cycles kaput; KAT13D; bHLHe8; mKIAA0334; 5330400M04Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CLOCK-11340H | Recombinant Human CLOCK, GST-tagged | E.coli | GST | 1-351a.a. | |
Human | CLOCK-75H | Recombinant Human CLOCK, GST-tagged | Wheat Germ | GST | ||
Human | CLOCK-7436HCL | Recombinant Human CLOCK 293 Cell Lysate | HEK293 | Non | ||
Human | CLOCK-1526H | Recombinant Human CLOCK protein, His & T7-tagged | E.coli | His&T7 | Ala34~Ala379 | |
Human | CLOCK-6888HF | Recombinant Full Length Human CLOCK Protein, GST-tagged | In Vitro Cell Free System | GST | 846 amino acids | |
Mouse | CLOCK-3596M | Recombinant Mouse CLOCK Protein | Mammalian Cell | His | ||
Mouse | CLOCK-1765M | Recombinant Mouse CLOCK Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Mouse | CLOCK-1765M-B | Recombinant Mouse CLOCK Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CLOCK-1459R | Recombinant Rat CLOCK Protein | Mammalian Cell | His | ||
Rat | CLOCK-1117R | Recombinant Rat CLOCK Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Rat | CLOCK-1117R-B | Recombinant Rat CLOCK Protein Pre-coupled Magnetic Beads | HEK293 | |||
Chicken | CLOCK-5488C | Recombinant Chicken CLOCK | Mammalian Cell | His | ||
Chicken | CLOCK-5748C | Recombinant Chicken CLOCK | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CLOCK involved in several pathways and played different roles in them. We selected most pathways CLOCK participated on our site, such as Circadian rhythm, Dopaminergic synapse, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLOCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Circadian rhythm | NR1D1;CRY2;CUL1;PRKAG2;BTRC;PRKAG1;CRY1;PRKAA1;CSNK1E |
Dopaminergic synapse | GNB3;PPP3CC;GRIN2A;KCNJ9;PPP2R1B;CALM4;SLC6A3;GRIA4;GNGT1 |
Herpes simplex infection | TAF13;Ifna11;CASP3B;SRSF3;PER1B;IKBKE;FASLG;TRAF3;IRF9 |
CLOCK has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLOCK itself. We selected most functions CLOCK had, and list some proteins which have the same functions with CLOCK. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
DNA binding | NR2F6;ZNF182;ZNF560;HOXB5A;HES1;MEF2CA;OASL1;ERCC6L;NR2F1A |
E-box binding | ARNTL2;MYOD1;ASCL2;ASCL1;TWIST1;ZEB1;TFAP4;CLOCK;LMO2 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | NEUROD6;ELF4;TFAM;NEUROD1;MTF1;NR3C1;CLOCK;NFIB;TLX1 |
chromatin DNA binding | H2AFY;FOXC2;HIST1H1E;CLOCK;XBP1;VAX2;HIST1H1B;H2AFY2;GATA1 |
core promoter binding | MED1;RELB;AGO1;ELK1;INSM1A;HDAC2;DHX36;SFPQ;RB1 |
histone acetyltransferase activity | EP300;KAT5;vnc;HTATIP;TAF1;CDYL;KAT2B;KAT6A;KAT6B |
protein binding | PAX8;PFDN5;IFT57;RBM14;PEX10;CCDC141;ASMTL;TTC3;TTLL10 |
protein dimerization activity | PIP4K2AA;ARNTL;DAO;HEY1;PRDX5;PIP;NPAS2;PPP3CB;HER4.2 |
sequence-specific DNA binding | CREBL2;DRGX;KLF2;BCL6;ZFP191;TBX5A;HOXD12;GZF1;SHOX2 |
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | JDP2;IRF7;CREB3;HIST2H3A;FOSB;RBPJA;ARNTL;FOSL1A;BATF |
transcription factor activity, sequence-specific DNA binding | MYT1LA;ZIC3;TP53;ZNF155;YY1;TCF3A;ZNF83;NR4A2B;STAT6 |
transcriptional activator activity, RNA polymerase II transcription factor binding | CREB1;MED12;NKX2;GBX2;LMO2;PITX1;PPARA;MIXL1;WWP2 |
CLOCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLOCK here. Most of them are supplied by our site. Hope this information will be useful for your research of CLOCK.
ARNTL; bamB; ARNTL2; mdm2_human_probe; Cry1
Research Area
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