Recombinant Human CLOCK, GST-tagged

Cat.No. : CLOCK-11340H
Product Overview : Recombinant Human CLOCK protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Availability November 05, 2024
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Description : This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-351a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Publication :
Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks (2019)
Gene Name : CLOCK clock homolog (mouse) [ Homo sapiens ]
Official Symbol : CLOCK
Synonyms : CLOCK; clock homolog (mouse); clock (mouse) homolog; circadian locomoter output cycles protein kaput; bHLHe8; KAT13D; KIAA0334; class E basic helix-loop-helix protein 8; circadian locomoter output cycles kaput protein;
Gene ID : 9575
mRNA Refseq : NM_004898
Protein Refseq : NP_004889
MIM : 601851
UniProt ID : O15516
Chromosome Location : 4q12
Pathway : BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem; Circadian rhythm - mammal, conserved biosystem; Circadian rhythm pathway, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem;
Function : DNA binding; E-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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