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COPS5

  • Official Full Name

    COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

  • Overview

    Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1-dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both the nucleus and the cytoplasm.
  • Synonyms

    COPS5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; MOV 34; SGN5; 38 kDa Mov34 homolog; signalosome subunit 5; jun activation domain-binding protein 1; MOV-34; MGC3149;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COPS5-40H Recombinant Human COPS5 protein, His-tagged E.coli His 349aa(including fusion tag)
Human COPS5-29878TH Recombinant Human COPS5, His-tagged E.coli His
Human COPS5-1705H Recombinant Human COPS5 Protein, GST-tagged Wheat Germ GST
Human COPS5-7356HCL Recombinant Human COPS5 293 Cell Lysate HEK293 N/A
Human COPS5-0864H Recombinant Human COPS5 Protein (A2-T257), Tag Free E.coli No tag A2-T257
Human COPS5-1959HF Recombinant Full Length Human COPS5 Protein, GST-tagged In Vitro Cell Free System GST 334 amino acids
Human COPS5-4129H Recombinant Human COPS5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COPS5-0865H Recombinant Human COPS5 Protein (A2-T257), GST tagged E.coli GST A2-T257
Human COPS5-1043HFL Recombinant Full Length Human COPS5 Protein, C-Flag-tagged Mammalian cells Flag
Human COPS5-643H Recombinant Human COPS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human COPS5-643H-B Recombinant Human COPS5 Protein Pre-coupled Magnetic Beads HEK293
Mouse COPS5-3782M Recombinant Mouse COPS5 Protein Mammalian Cell His
Mouse COPS5-1889M Recombinant Mouse COPS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse COPS5-1889M-B Recombinant Mouse COPS5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cops5-2263M Recombinant Mouse Cops5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque COPS5-973R Recombinant Rhesus monkey COPS5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COPS5-798R-B Recombinant Rhesus Macaque COPS5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COPS5-798R Recombinant Rhesus Macaque COPS5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish COPS5-10989Z Recombinant Zebrafish COPS5 Mammalian Cell His
Chicken COPS5-3370C Recombinant Chicken COPS5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COPS5 Related Articles
  • COPS5 Related Research Area

COPS5 involved in several pathways and played different roles in them. We selected most pathways COPS5 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Damage Recognition in GG-NERYY1A;INO80;COPS5;COPS4;COPS6;PARP1;INO80B;DDB1;COPS3
DNA RepairPPP4CA;CETN2;SPRTN;COPS6;COPS4;RNF4;RNF168;DNA2;PPP4R2A
Formation of TC-NER Pre-Incision ComplexZNF830;COPS7A;COPS7B;COPS2;COPS5;DDB1;KIAA1530;GPS1;ZFP830
Global Genome Nucleotide Excision Repair (GG-NER)PIAS3;INO80C;INO80B;COPS7A;NFRKB;MCRS1;YY1;GPS1;COPS4
HIF-1-alpha transcription factor networkNDRG1;TFF3;COPS5;EGLN3;ENG;ADM;GATA2;PLIN2;NPM1
Hypoxic and oxygen homeostasis regulation of HIF-1-alphaHIF3A;GNB2L1;COPS5;HIF1AN;NAA10
Nucleotide Excision RepairGTF2H1;COPS7B;INO80B;GTF2H2C;GPS1;CHD1L;ERCC6;POLE;KIAA1530
TGF-beta Receptor Signaling PathwaySKIA;ACVRL1;HOXD9A;EID2;JUNBA;TGFBR3;MEF2AA;NFYBB;SNIP1

COPS5 has several biochemical functions, for example, metal ion binding, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS5 itself. We selected most functions COPS5 had, and list some proteins which have the same functions with COPS5. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingLMAN2;CCDC76;ZNF167;ZMYND15;TGM2B;ARMC1;ARAP3;NEK1;ADHFE1
metallopeptidase activityLNPEP;ADAM12;ADAM23;ADAM10A;ADAMTS5;PAPPAA;MMP23BB;BMP1;CNDP2
protein bindingTMEM41A;KCNB1;TRAPPC5;C21orf7;SMC4;SMYD2;SNX5;NR4A3;GET4
transcription coactivator activityHCFC2;UTF1;GABPA;SOX10;EP300;JUP;RNF20;LPIN2;E4F1
translation initiation factor activityEIF4A2;EIF2S1A;EIF3F;MTIF2;EIF3EB;EIF2S3Y;EIF3S6IP;EIF2S1;EIF3HA
ubiquitin-specific protease activityUSP14;OTUB1B;ZRANB1B;USP1;ATXN3;VCPIP1;BAP1;CYLD;USP6

COPS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS5.

COPS3; GPS1; CUL4B; COPS6

Rajan, KE; Rajkumar, R; et al. Light-induced COP9 signalosome expression in the Indian false vampire bat Megaderma lyra. JOURNAL OF PHYSIOLOGICAL SCIENCES 60:43-49(2010).
Oron, E; Mannervik, M; et al. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. DEVELOPMENT 129:4399-4409(2002).
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