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COX10

Official Full Name

COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
Overview

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
Synonyms

COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; mitochondrial; 2410004F01Rik; AU042636; COX10_HUMAN; Cytochrome c oxidase assembly protein; Cytochrome c oxidase subunit X; Heme A farnesyltransferase; Heme O synthase; OTTMUSP00000006085; Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase, mitochondrial precursor; RP23-78H18.1; heme A: farnesyltransferase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Chicken
Human
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Rhesus Macaque
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Zebrafish

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COX10-1732H	Recombinant Human COX10 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COX10-387HCL	Recombinant Human COX10 cell lysate		N/A		Inquiry
Human	COX10-1992HF	Recombinant Full Length Human COX10 Protein, GST-tagged	In Vitro Cell Free System	GST	443 amino acids	Inquiry
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)	RFL26004AF	Recombinant Full Length Ashbya Gossypii Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (36-435)	Inquiry
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)	RFL10864KF	Recombinant Full Length Kluyveromyces Lactis Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (28-452)	Inquiry
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)	RFL70NF	Recombinant Full Length Neosartorya Fumigata Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (48-512)	Inquiry
Rhesus Macaque	COX10-980R	Recombinant Rhesus monkey COX10 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	COX10-805R	Recombinant Rhesus Macaque COX10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	COX10-805R-B	Recombinant Rhesus Macaque COX10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)	RFL26612YF	Recombinant Full Length Yarrowia Lipolytica Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged	E.coli expression system	His	Full Length (61-471)	Inquiry
Zebrafish	COX10-7606Z	Recombinant Zebrafish COX10	Mammalian Cell	His		Inquiry
Chicken	COX10-2403C	Recombinant Chicken COX10	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

COX10 involved in several pathways and played different roles in them. We selected most pathways COX10 participated on our site, such as Heme biosynthesis, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Heme biosynthesis	COX10;COX15;CPOX
Metabolic pathways	MBOAT2B;B3GALT2;PCYT1BA;RDH10;PIGK;FECH;LYCAT;HSD17B6;UGT1A6A
Metabolism	CES1;MTF1;AZIN1B;SUMF2;SLC35B2;CYP2U1;SULT4A1;SLC6A8;NOSTRIN
Metabolism of porphyrins	UGT1B7;UGT1B4;UGT1B1;UGT1B2;COX15;COX10;UGT1B5;CPOX;UGT1B3
Oxidative phosphorylation	NDUFA8;Atp5k;COX7A2L;ATP12A;ATP6V1E2;ATP6V1G2;COX7B2;ATP5D;NDUFA9
Porphyrin and chlorophyll metabolism	UGT1A3;ALAS1;UROS;UGT1A7;CP;BLVRA;GUSB;HEPH;UGT1A4

COX10 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, farnesyltranstransferase activity, protoheme IX farnesyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX10 itself. We selected most functions COX10 had, and list some proteins which have the same functions with COX10. You can find most of the proteins on our site.

Function	Related Protein
contributes_to cytochrome-c oxidase activity	COX15;COX10;NDUFA4
farnesyltranstransferase activity	COX10;GGPS1;FNTB
protoheme IX farnesyltransferase activity	UBIAD1;COX10

COX10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX10 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX10.