• Official Full Name

    COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

  • Background

    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
  • Synonyms

    COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; mitochondrial; 2410004F01Rik; AU042636; COX10_HUMAN; Cytochrome c oxidase assembly protein; Cytochrome c oxidase subunit X; Heme A farnesyltransferase; Heme O synthase; OTTMUSP00000006085; Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase, mitochondrial precursor; RP23-78H18.1; heme A: farnesyltransferase;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken COX10-2403C Recombinant Chicken COX10 Mammalian Cell His
    Human COX10-1732H Recombinant Human COX10 Protein, GST-tagged Wheat Germ GST
    Human COX10-387HCL Recombinant Human COX10 cell lysate N/A
    Rhesus Macaque COX10-805R Recombinant Rhesus Macaque COX10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque COX10-805R-B Recombinant Rhesus Macaque COX10 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque COX10-980R Recombinant Rhesus monkey COX10 Protein, His-tagged Mammalian Cell His
    Zebrafish COX10-7606Z Recombinant Zebrafish COX10 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    COX10 involved in several pathways and played different roles in them. We selected most pathways COX10 participated on our site, such as Heme biosynthesis, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Heme biosynthesisCPOX;COX15;COX10
    Metabolic pathwaysMPI;RGN;GNSB;SEPHS1;CS;ATP5I;CYP3A41A;MRI1;PANK1
    Metabolism of porphyrinsCOX15;COX10;CPOX;UGT1B5;UGT1B4;UGT1B1;UGT1B2;UGT1B3;UGT1B7
    Oxidative phosphorylationATP6V0C;NDUFA9;ATP6V1AA;COX7B;ATP5G3A;LHPP;UQCR11;NDUFC1;NDUFB2
    Porphyrin and chlorophyll metabolismUGT5G1;HMOX2;UGT1A1;P22;HMOX1A;BLVRA;UGT1A7;HCCSB;FECH

    COX10 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, farnesyltranstransferase activity, protoheme IX farnesyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX10 itself. We selected most functions COX10 had, and list some proteins which have the same functions with COX10. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytochrome-c oxidase activityCOX10;COX15;NDUFA4
    farnesyltranstransferase activityGGPS1;COX10;FNTB
    protoheme IX farnesyltransferase activityUBIAD1;COX10

    COX10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX10 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX10.

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