COX10
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Official Full Name
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
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Overview
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. -
Synonyms
COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast); COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase); protoheme IX farnesyltransferase, mitochondrial; mitochondrial; 2410004F01Rik; AU042636; COX10_HUMAN; Cytochrome c oxidase assembly protein; Cytochrome c oxidase subunit X; Heme A farnesyltransferase; Heme O synthase; OTTMUSP00000006085; Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase, mitochondrial precursor; RP23-78H18.1; heme A: farnesyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
- Chicken
- Human
- Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
- Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
- Rhesus Macaque
- Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | COX10-1732H | Recombinant Human COX10 Protein, GST-tagged | Wheat Germ | GST |
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| Human | COX10-387HCL | Recombinant Human COX10 cell lysate | Non |
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| Human | COX10-1992HF | Recombinant Full Length Human COX10 Protein, GST-tagged | In Vitro Cell Free System | GST | 443 amino acids |
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| Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) | RFL26004AF | Recombinant Full Length Ashbya Gossypii Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (36-435) |
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| Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) | RFL10864KF | Recombinant Full Length Kluyveromyces Lactis Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-452) |
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| Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) | RFL70NF | Recombinant Full Length Neosartorya Fumigata Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (48-512) |
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| Rhesus Macaque | COX10-980R | Recombinant Rhesus monkey COX10 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | COX10-805R | Recombinant Rhesus Macaque COX10 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rhesus Macaque | COX10-805R-B | Recombinant Rhesus Macaque COX10 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | RFL26612YF | Recombinant Full Length Yarrowia Lipolytica Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged | E.coli expression system | His | Full Length (61-471) |
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| Zebrafish | COX10-7606Z | Recombinant Zebrafish COX10 | Mammalian Cell | His |
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| Chicken | COX10-2403C | Recombinant Chicken COX10 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
COX10 involved in several pathways and played different roles in them. We selected most pathways COX10 participated on our site, such as Heme biosynthesis, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Heme biosynthesis | CPOX;COX15;COX10 |
| Metabolic pathways | AGXTB;POLR3A;PHOSPHO1;INPP5KA;BAAT;ACAT2;B3GNT3;NDUFS1;NME1 |
| Metabolism | CTRC;ITPKB;ACOT11;NUDT4B;SULT1C2;CYP2B6;CPNE6;ISCUB;ACOT10 |
| Metabolism of porphyrins | UGT1B4;UGT1B3;COX15;COX10;UGT1B5;CPOX;UGT1B7;UGT1B1;UGT1B2 |
| Oxidative phosphorylation | ATPV0E2;NDUFA13;NDUFS2;COX7B;Atp5k;ATP6V1E1B;LHPP;ATP6V1C2;NDUFV2 |
| Porphyrin and chlorophyll metabolism | UGT1A3;HMOX2A;CP;HMBSA;UGT1A6;HCCS;EPRS;CPOX;UGT1A1 |
COX10 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, farnesyltranstransferase activity, protoheme IX farnesyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX10 itself. We selected most functions COX10 had, and list some proteins which have the same functions with COX10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cytochrome-c oxidase activity | COX15;NDUFA4;COX10 |
| farnesyltranstransferase activity | GGPS1;COX10;FNTB |
| protoheme IX farnesyltransferase activity | UBIAD1;COX10 |
COX10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX10 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX10.
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