COX11

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COX11

Official Full Name COX11 cytochrome c oxidase assembly homolog (yeast)
Background Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.
Synonyms COX11; COX11 cytochrome c oxidase assembly homolog (yeast); COX11 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX11, mitochondrial; COX11P; cytochrome c oxidase assembly protein COX11; cytochrome c oxidase subunit 11; COX11 homolog; COX11 homolog, cytochrome c oxidase assembly protein (yeast); COX11 homolog, cytochrome c oxidase assembly protein
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX11-1734H Recombinant Human COX11 Protein, GST-tagged Wheat Germ GST
    Human COX11-7337HCL Recombinant Human COX11 293 Cell Lysate HEK293 N/A
    Mouse COX11-3807M Recombinant Mouse COX11 Protein Mammalian Cell His
    Rhesus Macaque COX11-981R Recombinant Rhesus monkey COX11 Protein, His-tagged Mammalian Cell His
    Zebrafish COX11-5315Z Recombinant Zebrafish COX11 Mammalian Cell His

    COX11 involved in several pathways and played different roles in them. We selected most pathways COX11 participated on our site, such as Electron Transport Chain, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Electron Transport Chain COX11; COX5B; COX6B1; COX6C; COX6A1; ATPIF1; UCP2; NDUFC2-KCTD14; COX7C; COX15
    Gene Expression FAM98B; TET2; ZNF446; ZNF12; SNRNP25; POP7; ZNF19; SF3A1; SNUPN; ALKBH8
    Generic Transcription Pathway ESRRG; ESR2B; NR5A1B; ZNF691; C7orf59; MED25; ZNF668; COX4I1; ARHGEF38; ZNF331
    Metabolic pathways RPN1; SMPD4; CYP2J2; TYMS; DNMT4; ITPKB; NANS; IDH2; ASL2; B3GNT4
    Metabolism DBH; ACOT2; KCNJ11; DDAH1; CKM; B3GNT3; MED16; APOEB; CIAO1; PLB1
    Oxidative phosphorylation NDUFAB1; ATP6V1E1; NDUFS2; NDUFA9A; NDUFB7; ATP6V1E2; NDUFB3; NDUFS1; NDUFA4L2; NDUFC1
    Respiratory electron transport FAM36A; ETFB; ETFA; LRPPRC; COX11; SCO1; COX16; NDUFAF7; TIMMDC1; C2orf56
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. NDUFAF6; NDUFAF2; UCP3; NDUFAF5; UCP2; COX16; TIMMDC1; FAM36A; LRPPRC; NDUFAF4

    COX11 has several biochemical functions, for example, copper ion binding, cytochrome-c oxidase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX11 itself. We selected most functions COX11 had, and list some proteins which have the same functions with COX11. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding TYR; S100A5; MOXD1L; DBH; IL1A; S100U; TRP53; AOC1; F5; MT1
    cytochrome-c oxidase activity COX7A2A; COX8A; COX7C; COX7A2L; COX5AA; COA6; COX8C; COX6A1; COX7A1; CYB5A
    electron carrier activity AKR1C4; ETFA; AOC2; NDUFS2; HAAO; COX5A; ACAD8; AIFM1; POR; ACOX3

    COX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX11.

    SQSTM1; RPL19; Csk; Smn1; Cep44; Kctd5; Bag2; COA3

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