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Official Full Name cytochrome c oxidase subunit IV isoform 1
Background Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3 of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]
Synonyms COX4I1; cytochrome c oxidase subunit IV isoform 1; COX4; COXIV; COX4-1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial; COX IV-1; cytochrome c oxidase polypeptide IV;
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX4I1-1742H Recombinant Human COX4I1 Protein, GST-tagged Wheat Germ GST
    Human COX4I1-26361TH Recombinant Human COX4I1 Wheat Germ N/A
    Human COX4I1-419H Recombinant Human COX4I1 Protein (23-169 aa), His-SUMO-tagged E.coli His/SUMO
    Human COX4I1-7334HCL Recombinant Human COX4I1 293 Cell Lysate HEK293 N/A
    Rat COX4I1-1550R Recombinant Rat COX4I1 Protein Mammalian Cell His
    Rhesus Macaque COX4I1-987R Recombinant Rhesus monkey COX4I1 Protein, His-tagged Mammalian Cell His
    Chicken COX4I1-2290C Recombinant Chicken COX4I1 Mammalian Cell His
    Zebrafish COX4I1-12731Z Recombinant Zebrafish COX4I1 Mammalian Cell His

    cox4i1 involved in several pathways and played different roles in them. We selected most pathways cox4i1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with cox4i1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease ATP5E; UQCR11; CASP8; COX4I1; COX7A2; SDHC; NDUFS5; NDUFA4L2; NDUFA12; NDUFA3
    Cardiac muscle contraction ATP2A2; ATP1A2; ATP1A4; COX5A; COX6A2; RYR2; ATP1A3; TPM2; CACNB3A; COX7A1
    Electron Transport Chain COX8A; ATP5L; COX15; COX6C; COX7A2; SURF1; ATP5H; COX6A2; UCP2; NDUFC2-KCTD14
    Gene Expression ZNF776; ZNF498; PHF19; RORAA; CLP1; ZNF334; GATAD2AB; HNRNPA2B1; GTF3C5; LSM10
    Generic Transcription Pathway ZNF225; ZNF184; ZNF621; NKX2; ZFP37; ZNF23; YAP1; JUNB; ZNF264; ZNF256
    Huntingtons disease UQCRFS1; GPX1; COX6A1; ATP5H; IFT57; ATP5A1; ATP5E; PLCB2; NDUFS8; DNAI2
    Metabolic pathways CTPS2; ABP1; PYGMA; ATP6AP1; FH1; PIGN; ATP5J2; TAT; ALG11; ACSBG1
    Metabolism GGTLC1; AQP1A.2; SLC23A2; C2orf56; SLC27A2; CYP2S1; ISCUB; GLYATL1; GLTPA; SCO1

    cox4i1 has several biochemical functions, for example, cytochrome-c oxidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cox4i1 itself. We selected most functions cox4i1 had, and list some proteins which have the same functions with cox4i1. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX6A2; COX6B1; CYB5A; COX7B2; COX7A1; COX7A2A; COX5AA; COX5B; COX6B2; COX15
    protein binding PTPRG; ESRRG; SCG5; PVRL4; ITGAX; CCDC101; PLAU; CCDC109A; GYS1; CT45A3

    cox4i1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cox4i1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cox4i1.

    SDCBP; env; 40038273; MT-CO1; MT-CO2; IKBKE; TMBIM4; env; HSPD1; TUBG1; JAK3; Smn1; COX6A2; MCL1; ICT1

    Castelblanco, E; Gallel, P; et al. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. HUMAN PATHOLOGY 43:1103-1112(2012).
    Arnold, S; et al. Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection. MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION: NUCLEAR-ENCODED GENES, ENZYME REGULATION, AND PATHOPHYSIOLOGY 748:305-339(2012).

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