COX4I1 Protein


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Official Full Name cytochrome c oxidase subunit IV isoform 1
Background Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3 of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]
Synonyms COX4I1; cytochrome c oxidase subunit IV isoform 1; COX4; COXIV; COX4-1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial; COX IV-1; cytochrome c oxidase polypeptide IV;
    • Species :
    • Bos taurus (Bovine)
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • SUMO
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX4I1-1742H Recombinant Human COX4I1 Protein, GST-tagged Wheat Germ GST Inquiry
    Human COX4I1-26361TH Recombinant Human COX4I1 Wheat Germ N/A Inquiry
    Rat COX4I1-1550R Recombinant Rat COX4I1 Protein Mammalian Cell His Inquiry
    Rhesus Macaque COX4I1-987R Recombinant Rhesus monkey COX4I1 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken COX4I1-2290C Recombinant Chicken COX4I1 Mammalian Cell His Inquiry
    Zebrafish COX4I1-12731Z Recombinant Zebrafish COX4I1 Mammalian Cell His Inquiry
    Human COX4I1-7334HCL Recombinant Human COX4I1 293 Cell Lysate HEK293 N/A Inquiry
    Rat COX4I1-1207R Recombinant Rat COX4I1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human COX4I1-2003HF Recombinant Full Length Human COX4I1 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Rhesus Macaque COX4I1-812R Recombinant Rhesus Macaque COX4I1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human COX4I1-831H Recombinant Human COX4I1 Protein, His-tagged E.coli N-His Inquiry
    Human COX4I1-90HF Recombinant Full Length Human COX4I1 Protein In Vitro Cell Free System Inquiry
    Bos taurus (Bovine) RFL22307BF Recombinant Full Length Bovine Cytochrome C Oxidase Subunit 4 Isoform 1, Mitochondrial(Cox4I1) Protein, His-Tagged E.coli expression system His Inquiry
    Human COX4I1-419H Recombinant Human COX4I1 Protein (23-169 aa), His-SUMO-tagged E.coli His/SUMO Inquiry

    COX4I1 involved in several pathways and played different roles in them. We selected most pathways COX4I1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease MT-ATP6; NDUFS1; ATP5G3; IL1B; MAPK1; CALM1; BID; CALML3; FAS; COX7A2
    Cardiac muscle contraction CACNA1D; TNNC1B; CACNA2D2; CACNG3; COX6C; TPM4A; FXYD2; ATP1B1A; VMHC; ATP1A4
    Electron Transport Chain COX6C; UCP3; UCP2; NDUFS7; COX6A1; COX6B1; COX15; COX8A; COX5B; NDUFC2-KCTD14
    Gene Expression HIPK1; SUPT5H; EHMT2; PRPF8; CDK9; ZNF180; PAIP1; EEF1A2; ZNF614; SF3B4
    Generic Transcription Pathway ZNF764; TEAD1A; ZNF224; ZNF556; ZNF3; ZNF436; ZNF222; COX5B; NR2F1A; CTGF
    Huntingtons disease DNALC1; UQCR11; POLR2F; DNAI2; ATP5E; SP1; SLC25A4; COX7A2L; NDUFA2; EP300
    Metabolic pathways PTGES3A; STT3A; HEXA; ATP6V1B2; GGT1; TKTB; ASL; NT5C1AA; SDSL; ALOX8
    Metabolism CDO1; SLC5A4; CIAO1; ELOVL1A; PYGMB; LYRM4; CYP2K19; SLC4A1B; DHCR7; SLC5A6B

    COX4I1 has several biochemical functions, for example, cytochrome-c oxidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I1 itself. We selected most functions COX4I1 had, and list some proteins which have the same functions with COX4I1. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX11; COX6A2; COX7A2A; COX7C; COX5AA; COX7A3; COX8C; COX4I1; COX7A2; CYB5A
    protein binding LETM1; EEF1E1; CSNK1A1; PHF7; NR0B1; WAC; C9orf100; SCRN1; ARR3; Unc5b

    COX4I1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I1.

    SDCBP; env; 40038273; MT-CO1; MT-CO2; IKBKE; TMBIM4; env; HSPD1; TUBG1; JAK3; Smn1; COX6A2; MCL1; ICT1

    Castelblanco, E; Gallel, P; et al. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. HUMAN PATHOLOGY 43:1103-1112(2012).
    Arnold, S; et al. Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection. MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION: NUCLEAR-ENCODED GENES, ENZYME REGULATION, AND PATHOPHYSIOLOGY 748:305-339(2012).

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