CSK

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CSK

Official Full Name c-src tyrosine kinase
Background Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds
Synonyms CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CSK-1394H Recombinant Human CSK (Active), GST-tagged Sf9 Insect Cell GST
    Human CSK-170H Recombinant Human C-src Tyrosine Kinase E.coli N/A
    Human CSK-1979H Recombinant Human CSK Protein, GST-tagged Wheat Germ GST
    Human CSK-26133TH Recombinant Human CSK, His-tagged E.coli His
    Human CSK-27872TH Native Human CSK Insect Cell N/A
    Human CSK-27H Recombinant Human c-src tyrosine kinase Sf9 Insect Cell N/A
    Human CSK-288H Recombinant Human C-src Tyrosine Kinase, GST-tagged, Active Sf9 Insect Cell GST
    Human CSK-3345H Recombinant Human CSK Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CSK-342H Recombinant Human CSK Protein, GST-tagged Insect Cell GST
    Human CSK-388H Recombinant Human C-Src Tyrosine Kinase, GST-tagged Sf9 Insect Cell GST
    Human CSK-576H Recombinant Human CSK Protein, His-tagged E.coli His
    Human CSK-619H Recombinant Human c-src tyrosine kinase, His-tagged E.coli His
    Human CSK-6272H Recombinant Human CSK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CSK-628HCL Recombinant Human CSK cell lysate Insect Cell N/A
    Mouse CSK-001MCL Recombinant Mouse CSK cell lysate Insect Cell N/A
    Mouse CSK-436M Recombinant Mouse Csk, Gly & Pro tagged Insect Cell His
    Mouse CSK-925M Recombinant Mouse CSK Protein, GST & His-tagged Insect Cell GST/His
    Mouse Csk-942M Recombinant Mouse Csk Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CSK-1628R Recombinant Rat CSK Protein Mammalian Cell His
    Rhesus Macaque CSK-1057R Recombinant Rhesus monkey CSK Protein, His-tagged Mammalian Cell His
    Chicken CSK-6976C Recombinant Chicken CSK Mammalian Cell His
    Zebrafish CSK-4794Z Recombinant Zebrafish CSK Mammalian Cell His

    CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation KIDINS220B; WDR83; PEBP1; IL17RD; SPTBN2; CRK; DAB2IPB; NTF7; PSMA8; CNKSR1
    Adaptive Immune System TRIM11; MGC174152; SIGLEC8; SPSB4; UBE2J2; SEC24A; FGFR1B; CTSO; FCGR1B; KIF26A
    Axon guidance ITSN1; EFNA4; COL9A3; RASGRP1; COL4A5; PEBP1; EPHA4; EPHB4A; CSNK2A1; PLXND1
    B Cell Receptor Signaling Pathway GRB2; CD79B; SYK; KRAS; cgr2b; ITK; SOS1; DOK3; FCGR2B; PIK3CD
    BCR signaling pathway CSK; POU2F2; MAP4K1; MALT1; PAG1; DOK1; IBTK; CSNK2A1; NETO2
    CXCR4-mediated signaling events ADRBK1; ARR3; CFL1; MAPKAP1; JAK2; GNA13; BLK; GNB2L1; CSK; PAG1
    Costimulation by the CD28 family MAP3K8; PDPK1A; CTLA4; CSK; THEM4; HLA-DQB2; MAPKAP1; BTLA
    Cytokine Signaling in Immune system USP18; TNFSF13B; KPNA4; NRG3; EIF4A2; DUSP1; SPRED3; IFIT11; NOD1; TRIM17

    CSK has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ABCD2; UBE2L3A; SMYHC1; DGKZ; STK17A; cka1; MAP3K2; STK4; SNRKB; CLK4B
    identical protein binding VPS4B; INS2; PFKL; PHYKPL; MMP9; ROBO1; LRRK1; DAPK2; STXBP1; MLL1
    metal ion binding CYP4V8; ZSCAN16; PDE3B; CHD4A; NR5A1A; ZFP382; FDX1B; LNPB; MT2; B3GAT2
    non-membrane spanning protein tyrosine kinase activity JAK2A; ITK; YES1; LCK; PTK2; BMX; PTK2BB; EIF2AK2; DYRK1A; TNK2B
    proline-rich region binding ABI2; TCERG1; RABAC1; CSK; PRPF40A; FAM59A; GHR; GAREM; ITSN1; CCND1
    protein C-terminus binding YWHAB; ATP2A2; TOP2A; PICK1; CEP135; CORO1A; PRDX3; DLG4; CDC37; JAK2
    protein binding UGGT1; MAP3K5; ATP6V0D1; ZC3H14; IFNAR1; FLT4; SWSAP1; PRL2C2; PPID; EVI5
    protein kinase A catalytic subunit binding PKIA; GSK3B; EZR; PJA2; RYR2; PRKAR2B; GSK3A; SOX9; PRKAR1A; PRKAR2A
    protein phosphatase binding CSF1R; ROS1; FGF19; RPA2; LCK; JAK3; DLG3; ITPR1; PPP1R3G; CSK
    protein tyrosine kinase activity DYRK4; FGFR1A; DYRK2; CAMKK2; KITA; EGFRA; YES1; NTRK3A; DYRK1A; MAP2K5
    receptor binding HIST2H3C2; NRXN1; FYNB; PSPN; FGF6B; FGF11A; CALCA; FGF13B; SNX17; WNT2BB

    CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.

    SRC; PTPRC; EGFR; IGF1R; G3BP1

    Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).
    Dokmanovic, M; Wu, Y; et al. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. CANCER BIOLOGY & THERAPY 15:1029-1041(2014).

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