| Official Full Name | c-src tyrosine kinase |
| Background | Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds |
| Synonyms | CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | KIDINS220B; WDR83; PEBP1; IL17RD; SPTBN2; CRK; DAB2IPB; NTF7; PSMA8; CNKSR1 |
| Adaptive Immune System | TRIM11; MGC174152; SIGLEC8; SPSB4; UBE2J2; SEC24A; FGFR1B; CTSO; FCGR1B; KIF26A |
| Axon guidance | ITSN1; EFNA4; COL9A3; RASGRP1; COL4A5; PEBP1; EPHA4; EPHB4A; CSNK2A1; PLXND1 |
| B Cell Receptor Signaling Pathway | GRB2; CD79B; SYK; KRAS; cgr2b; ITK; SOS1; DOK3; FCGR2B; PIK3CD |
| BCR signaling pathway | CSK; POU2F2; MAP4K1; MALT1; PAG1; DOK1; IBTK; CSNK2A1; NETO2 |
| CXCR4-mediated signaling events | ADRBK1; ARR3; CFL1; MAPKAP1; JAK2; GNA13; BLK; GNB2L1; CSK; PAG1 |
| Costimulation by the CD28 family | MAP3K8; PDPK1A; CTLA4; CSK; THEM4; HLA-DQB2; MAPKAP1; BTLA |
| Cytokine Signaling in Immune system | USP18; TNFSF13B; KPNA4; NRG3; EIF4A2; DUSP1; SPRED3; IFIT11; NOD1; TRIM17 |
CSK has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCD2; UBE2L3A; SMYHC1; DGKZ; STK17A; cka1; MAP3K2; STK4; SNRKB; CLK4B |
| identical protein binding | VPS4B; INS2; PFKL; PHYKPL; MMP9; ROBO1; LRRK1; DAPK2; STXBP1; MLL1 |
| metal ion binding | CYP4V8; ZSCAN16; PDE3B; CHD4A; NR5A1A; ZFP382; FDX1B; LNPB; MT2; B3GAT2 |
| non-membrane spanning protein tyrosine kinase activity | JAK2A; ITK; YES1; LCK; PTK2; BMX; PTK2BB; EIF2AK2; DYRK1A; TNK2B |
| proline-rich region binding | ABI2; TCERG1; RABAC1; CSK; PRPF40A; FAM59A; GHR; GAREM; ITSN1; CCND1 |
| protein C-terminus binding | YWHAB; ATP2A2; TOP2A; PICK1; CEP135; CORO1A; PRDX3; DLG4; CDC37; JAK2 |
| protein binding | UGGT1; MAP3K5; ATP6V0D1; ZC3H14; IFNAR1; FLT4; SWSAP1; PRL2C2; PPID; EVI5 |
| protein kinase A catalytic subunit binding | PKIA; GSK3B; EZR; PJA2; RYR2; PRKAR2B; GSK3A; SOX9; PRKAR1A; PRKAR2A |
| protein phosphatase binding | CSF1R; ROS1; FGF19; RPA2; LCK; JAK3; DLG3; ITPR1; PPP1R3G; CSK |
| protein tyrosine kinase activity | DYRK4; FGFR1A; DYRK2; CAMKK2; KITA; EGFRA; YES1; NTRK3A; DYRK1A; MAP2K5 |
| receptor binding | HIST2H3C2; NRXN1; FYNB; PSPN; FGF6B; FGF11A; CALCA; FGF13B; SNX17; WNT2BB |
CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.
SRC; PTPRC; EGFR; IGF1R; G3BP1
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