csk
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  • Official Full Name
  • c-src tyrosine kinase
  • Background
  • Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFKs) by phosphorylation of the SFK carboxy-terminal tyrosine (1,2). Phosphorylated carboxy-terminal tyrosine binds
  • Synonyms
  • CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393
Cat.#:CSK-342HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSK Protein, GST-tagged
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Cat.#:CSK-1979HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CSK Protein, GST-tagged
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Cat.#:CSK-3345HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSK Protein, MYC/DDK-tagged
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Cat.#:CSK-576HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSK Protein, His-tagged
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Cat.#:CSK-27HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human c-src tyrosine kinase
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Cat.#:CSK-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C-src Tyrosine Kinase
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Cat.#:CSK-26133THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSK, His-tagged
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Cat.#:CSK-288HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human C-src Tyrosine Kinase, GST-tagged, Active
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Cat.#:CSK-619HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human c-src tyrosine kinase, His-tagged
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Cat.#:CSK-436MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Csk, Gly & Pro tagged
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Cat.#:CSK-925MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CSK Protein, GST & His-tagged
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Cat.#:CSK-1628RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CSK Protein
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Cat.#:CSK-1057RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CSK Protein, His-tagged
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Cat.#:CSK-6976CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CSK
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Cat.#:CSK-4794ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CSK
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Cat.#:CSK-388HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human C-Src Tyrosine Kinase, GST-tagged
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Cat.#:CSK-1394HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CSK (Active), GST-tagged
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Cat.#:CSK-27872THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameNative Human CSK
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Cat.#:CSK-628HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSK cell lysate
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Cat.#:CSK-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CSK cell lysate
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Involved Pathway

CSK involved in several pathways and played different roles in them. We selected most pathways CSK participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
FGF10B; SPNA2; PSMD14; CRK; RASGRP4; FGF18B; NRG4; FRS2B; IL17RD; DUSP4
Adaptive Immune System
ICAM4; GRAP2A; CTLA4; SIGLEC12; FGF8B; FRS2B; HCST; PAG1; TREML4; SLAMF6
Axon guidance
MET; PAQR3B; ARPC5; SPTB; EPHA3; MAPK3; KIF4A; SPNA1; COL4A4; PPP3CB
B Cell Receptor Signaling Pathway
CTNNB2; ARPC3; BLNK; PLCG2; RAP2A; CDK4; PIK3CG; DAPP1; CDK7; VAV2
BCR signaling pathway
CSK; DOK1; IBTK; PAG1; MALT1; NETO2; CSNK2A1; MAP4K1; POU2F2
CXCR4-mediated signaling events
ARR3; DNM1; MAPKAP1; CFL1; ADRBK1; CSK; CRK; BLK; GNB2L1; JAK2
Costimulation by the CD28 family
CSK; MAPKAP1; MAP3K8; CTLA4; PDPK1A; THEM4; BTLA; HLA-DQB2
Cytokine Signaling in Immune system
RASGEF1A; TRIM45; EDARADD; FRS3; TRIM17; PAQR3B; IFITM3; EIF4G1; TNFRSF13C; SPTBN1

Protein Function

CSK has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSK itself. We selected most functions CSK had, and list some proteins which have the same functions with CSK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CHD7; CKMT1; MAPKAPK2A; MYH8; CDC42BPG; DNAHC8; BBS12; ITGB1BP3; EPHB4A; MAP3K15
Function identical protein binding
Related Protein PICK1; PSMA7; PRDX1; CEP170L; UGP2; CNTN2; DAPK3; OAT; HSPB8; HSP90AA1
Function metal ion binding
Related Protein PM20D1; MICAL2B; LHX8A; PITPNM1; ZDHHC20A; ZDHHC3A; RNF149; ACVR2A; ABAT; ADCY7
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PTK2AA; PTK2B; STYK1; HCK; TYK2; EIF2AK2; BAZ1B; SRMS; FES; FGR
Function proline-rich region binding
Related Protein BAIAP2L1; GHR; ABI2; CYLD; CSK; PFN1; YAP1; WBP4; ABL1; GAREM
Function protein C-terminus binding
Related Protein SP1; PABPC1; ITGB3BP; ERCC3; HSPG2; SNTG1; SHANK2; SLC4A1; MAP3K7; IFT52
Function protein binding
Related Protein DOT1L; MTA1; CYB561; LRRC6; STRA13; TBC1D23; SLC22A6; TRIM41; POU2AF1; ARL13B
Function protein kinase A catalytic subunit binding
Related Protein PRKAR2B; PRKAR1B; RYR2; SOX9; PJA2; GSK3B; GSK3A; PRKAR1A; EZR; PKIA
Function protein phosphatase binding
Related Protein SKAP1; PPP1R3C; VCAN; GRB2; CDH2; AP3B1; ITPR1; ERBB2; MAPK14; CSK
Function protein tyrosine kinase activity
Related Protein MAP2K6; INSR; FGFR1B; FES; TEK; TTK; INSRA; BMX; CLK4; MAP2K7
Function receptor binding
Related Protein CCL15; YES1; SCYL2; DDO; RSPO1; TRDN; PSPN; HLA-F; P2RX7; NRXN1

Interacting Protein

CSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CSK.
SRC; PTPRC; EGFR; IGF1R; G3BP1

CSK Related Articles

Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).
Dokmanovic, M; Wu, Y; et al. Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. CANCER BIOLOGY & THERAPY 15:1029-1041(2014).