CUL3
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Official Full Name
cullin 3
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Overview
CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division. -
Synonyms
CUL3; cullin 3; cullin-3; CUL-3; OTTHUMP00000164219; OTTHUMP00000203839; OTTHUMP00000203840;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CUL3 Related Articles
CUL3 involved in several pathways and played different roles in them. We selected most pathways CUL3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | BIRC3;KLHL9;HERC2;HUWE1;UBE2M;CUL3A;VHL;ANAPC1;TCEB1 |
CUL3 has several biochemical functions, for example, POZ domain binding, cyclin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL3 itself. We selected most functions CUL3 had, and list some proteins which have the same functions with CUL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| POZ domain binding | KLHL17;CUL3;Trl |
| cyclin binding | CDK4;CDKN1A;CDK13;CDK14;CDK12;CDK5RAP3;INCA1;FBXW7;HDAC3 |
| protein binding | MB21D2;PPFIA1;NSG1;LMO2;RBP4;HDAC7A;IGF1R;COL4A3;SFRP4 |
| protein heterodimerization activity | PIK3R1;CLCN3;HIST1H2BK;LIMK1;PAFAH1B2;ADORA2A;ATF2;MAFA;ERBB2 |
| protein homodimerization activity | HRSP12;PTPRO;ALDH5A1;ACTN2;ZBTB1;IDE;CLN6;CBS;CD8A |
| contributes_to ubiquitin protein ligase activity | FBXL6;CUL1;FBXL3A;CUL1B;CUL5;SKP2;FBXL12;UBXN6;CUL1A |
| ubiquitin protein ligase binding | PRR5L;AXIN2;DERL1;PA2G4;NFKBIA;HDAC6;POU5F1;PDE4D;AKTIP |
| contributes_to ubiquitin-protein transferase activity | KLHL22;CCIN;KLHL7;KLHL21;BTRC;KLHL5;KLHL18;BARD1;KLHL41B |
CUL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL3.
CASP8; SPOP; KLHL2; TNFAIP1; KLHL12; FLJ13057
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, targeting CUL3 as a therapeutic strategy is being explored, particularly in the context of cancer and neurodegenerative diseases.
Elevated levels of CUL3 protein expression have been observed in certain types of cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis.
CUL3 forms complexes with various substrate receptors and adaptor proteins, allowing it to target specific proteins for degradation via the ubiquitin-proteasome system.
CUL3 mutations may affect the response to certain cancer therapies by altering the degradation of drug targets, potentially leading to drug resistance.
Yes, mutations in the CUL3 gene have been linked to a rare genetic disorder called pseudohypoaldosteronism type II (PHAII), which affects the regulation of blood pressure and electrolyte balance.
Customer Reviews (3)
Write a reviewIts superior purity and stability ensure reliable and accurate results, instilling confidence in my research.
Whether I am studying protein interactions, cellular localization, or signaling pathways, the CUL3 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.
Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.
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