CYGB

  • Official Full Name

    cytoglobin
  • Overview

    This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate;hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may;be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a;retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.
  • Synonyms

    CYGB;cytoglobin;HGB;histoglobin;STAP;stellate cell activation associated protein;stellate cell activation-associated protein

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Chicken
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
  • SUMO
  • Myc
  • DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYGB-1132R Recombinant Rhesus monkey CYGB Protein, His-tagged Mammalian Cells Rhesus macaque His
CYGB-1711R Recombinant Rat CYGB Protein Mammalian Cells Rat His
CYGB-1874C Recombinant Chicken CYGB Mammalian Cells Chicken His
CYGB-2231H Recombinant Human CYGB Protein, GST-tagged Wheat Germ Human GST
CYGB-2578H Recombinant Human Cytoglobin, His-tagged E.coli Human His
CYGB-26694TH Recombinant Human CYGB, His-tagged E.coli Human His 190 amino acids
CYGB-371H Recombinant Human CYGB protein, His-tagged E.coli Human His Met1-Pro190
CYGB-7803H Recombinant Human CYGB E.coli Human Non
CYGB-7134HCL Recombinant Human CYGB 293 Cell Lysate HEK293 Human Non
CYGB-1370R Recombinant Rat CYGB Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CYGB-1370R-B Recombinant Rat CYGB Protein Pre-coupled Magnetic Beads HEK293 Rat
CYGB-1731H Recombinant Human CYGB Protein (Met1-Pro190), C-His tagged E.coli Human His Met1-Pro190
CYGB-2271HF Recombinant Full Length Human CYGB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 190 amino acids
CYGB-2783H Recombinant Human CYGB protein, His-SUMO-tagged E.coli Human His&SUMO 1-190aa
Cygb-2784R Recombinant Rat Cygb protein, His&Myc-tagged E.coli Rat His&Myc 1-190aa
Cygb-535M Recombinant Mouse Cygb Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
CYGB-669H Recombinant Human CYGB Protein, His-tagged E.coli Human His Met1~Pro190
Cygb-670R Recombinant Rat Cygb Protein, His-tagged E.coli Rat His Met1~Pro190
CYGB-957R Recombinant Rhesus Macaque CYGB Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYGB-957R-B Recombinant Rhesus Macaque CYGB Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYGB involved in several pathways and played different roles in them. We selected most pathways CYGB participated on our site, such as Metabolism,Metabolism of nitric oxide,eNOS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism NUDT3B,SLC35B2,HAS1,LOC100686744,NUDT3A,CYP27A1,CYGB1,CHST14,SLC25A27,CYP2AD2
    eNOS activation DDAH2,LYPLA1,DDAH1,ZDHHC21,CYGB2,CYGB1
    eNOS activation and regulation SPRB,LYPLA1,NOSTRIN,ZDHHC21,CYGB1,DDAH1,DDAH2,CYGB2,GCHFR,NOSIP
    Metabolism of nitric oxide DDAH1,DDAH2,ZDHHC21,GCHFR,CYGB1,NOSIP,NOSTRIN,LYPLA1,CYGB2,SPRB

    Protein Function

    CYGB has several biochemical functions, for example, catalase activity,fatty acid peroxidase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYGB itself. We selected most functions CYGB had, and list some proteins which have the same functions with CYGB. You can find most of the proteins on our site.

    Function Related Protein
    peroxidase activity MPX,GPX1A,DUOX2,GPX5,IPCEF1,GPX1B,MGST3,PRDX1,GPX7,TPO
    catalase activity GPX7,CAT
    heme binding PTGS2B,SRC,PGRMC2,IDO2,CYP2D26,NGB,MPO,CYP39A1,CYP2A4,MPX
    nitric oxide dioxygenase activity POR
    oxygen transporter activity HBD,IPCEF1,HBA2,HBG2,HBB-BH1,HBAA,BA1,HBM,HBB,HBAA1
    oxygen binding CYP2D26,CYP4B1,CYP2F1,CYP2A7,CYP2F2,CYP2C54,HBBE3,CBS,CYP2E1,HBBE1.1
    protein binding CGA,GRIN2B,DULLARD,RAB14,PRKG1,RAB39A,RPS6KB1,USO1,VPS24,CC2D1B
    iron ion binding CYP2K22,TPH1,CYP2J5,TYW1B,POR,CYP8B2,CYP4A11,CYP46A1.4,LEPRE1,CYP2A6

    Interacting Protein

    CYGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYGB here. Most of them are supplied by our site. Hope this information will be useful for your research of CYGB.

    DDI1;ATP13A2

    Resources

    References

    • Fujita, Y; Koinuma, S; et al. Melanoma Transition Is Frequently Accompanied by a Loss of Cytoglobin Expression in Melanocytes: A Novel Expression Site of Cytoglobin. PLOS ONE 9:-(2014).
    • Motoyama, H; Komiya, T; et al. Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver. LABORATORY INVESTIGATION 94:192-207(2014).

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