cyp19a1

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cyp19a1

Official Full Name cytochrome P450, family 19, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
Synonyms CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cyp19a1-2411M Recombinant Mouse Cyp19a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYP19A1-300H Recombinant Human CYP19A1 protein, GST-tagged E. coli GST
    Human CYP19A1-301H Recombinant Human CYP19A1 protein, His-tagged E. coli His
    Human CYP19A1-302H Recombinant Human CYP19A1 protein, His-tagged E. coli His
    Human ARO-3637H Recombinant Human ARO, His-tagged E.coli His
    Human CYP19A1-145H Recombinant Human CYP19A1 Mammalian Cell His
    Human CYP19A1-158H Recombinant Human CYP19A1 protein, GST-tagged Wheat Germ GST
    Human CYP19A1-26393TH Recombinant Human CYP19A1 Wheat Germ N/A
    Human CYP19A1-26421TH Recombinant Human CYP19A1 Wheat Germ N/A
    Human CYP19A1-432H Recombinant Human CYP19A1 protein E.coli N/A
    Human CYP19A1-548H Recombinant Human CYP19A1 Protein, His-tagged E.coli His
    Human CYP19A1-7127HCL Recombinant Human CYP19A1 293 Cell Lysate HEK293 N/A
    Mouse CYP19A1-4148M Recombinant Mouse CYP19A1 Protein Mammalian Cell His
    Chicken CYP19A1-1157C Recombinant Chicken CYP19A1 Mammalian Cell His

    cyp19a1 involved in several pathways and played different roles in them. We selected most pathways cyp19a1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Endogenous sterols, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp19a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP4F22; CYP24A1; CYP2S1; CYP27A1; GLYATL1; GSTO2; CYP2Y3; ACY3.1; UGT1B7; UGT1B5
    Cytochrome P450 - arranged by substrate type CYP2K6; FDXR; CYP2V1; CYP4T8; CYP4A11; CYP1A1; CYP8B2; CYP2K17; CYP2S1; CYP3A7
    Endogenous sterols CYP1B1; FDXR; CYP8B2; CYP17A1; CYP11B2; CYP46A1; CYP51A1; CYP7A1; CYP19A1; CYP21A2
    Estrogen biosynthesis AKR1B15; HSD17B11; CYP19A1
    FSH signaling pathway AREG; CYP19A1; CGA
    Integrated Breast Cancer Pathway AHR; UBE2F; CCNB1IP1; C21orf7; DAG1; USP15; BACH1; GRN; DHTKD1; RPP38
    Metabolic pathways HSD3B7; ALDH2; NDUFA4L; AK4; COX7B2; NDUFC1; RPN1; GOT1; ATP6V0C; DHRS4L2
    Metabolism ACOT9; CLPS; GLTPD1; ARSK; SLC25A20; CKB; CETP; CDS1; BCKDK; ITPKA

    cyp19a1 has several biochemical functions, for example, aromatase activity, electron carrier activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp19a1 itself. We selected most functions cyp19a1 had, and list some proteins which have the same functions with cyp19a1. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP1A2; CYP2J6; CYP2B19; CYP2C39; CYP2A12; CYP2U1; CYP2C54; CYP2D6; CYP2H1; CYP2A13
    electron carrier activity ACOX1; NDUFV2; LOXL2; NDUFS1; CYBA; AKR7A2; TXNRD1; AOX3L1; GLRX5; DHRS3
    heme binding CYP2D6; PTGESL; HBB-B2; HBQ1; CYP3A5; CBSB; AMBP; HBG2; CYP2F1; HBBE1.1
    iron ion binding FAM84B; TYW1; ETHE1; CYP2J5; CYP1C1; ALOX12B; CYP2N13; P4HA1A; ACO2; HBB-BH1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2AD6; CYP2C70; CYP2D26; CYP1B1; CYP2Y3; CYP2X9; CYP2AA12; CYP2C18; CYP2AD3; CYP2B6
    oxygen binding HBAA1; HBAD; MB; TH; CYP2K17; CYP2D6; CYP3A7; CYP2P6; BA1; CYP2V1

    cyp19a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp19a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp19a1.

    A2M

    Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).

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