CYP1A1
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Official Full Name
cytochrome P450, family 1, subfamily A, polypeptide 1
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Overview
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. -
Synonyms
CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CP 11; CP1A1_HUMAN; CYP 1; CYP1; CYPIA1; Cytochrome P1 450 dioxin inducible; Cytochrome P1-450; Cytochrome P1-450 dioxin-inducible; Cytochrome P450 family 1 subfamily A polypeptide 1; Cytochrome P450 form 6; Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P450 form 6; P450 P1; Xenobiotic monooxygenase; OTTHUMP00000183469; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; P1-450; P450-C;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP1A1 Related Articles
CYP1A1 involved in several pathways and played different roles in them. We selected most pathways CYP1A1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | CDKN1B;AHRR;EGFR;AIP;NQO1;CDC37;JUN;CYP1A1;PTGES3 |
| Arachidonic acid metabolism | GGT5;CYP2P10;PTGS2;AWAT1;CYP2P7;PLA2G2D;CYP1A2;PLA2G6;CBR1L |
| Benzo(a)pyrene metabolism | AKR1C4;CYP1B1;CYP3A4;AKR1C2;AKR1A1;FAM84B;CYP1A1 |
| Biological oxidations | GLYATL1;CYP4A11;ADH8B;CYP2W1;MTRR;CYP2C19;CYP27A1;CYP21A2;SULT1C4 |
| Chemical carcinogenesis | CHRNA7;GSTM4;GSTO1;MGST1;CYP2C50;GSTP1;ALDH1A3;MGST3;AKR1C2 |
| Cytochrome P450 - arranged by substrate type | CYP2K18;CYP2F1;CYP2R1;CYP2AD3;CYP8B2;FAM84B;CYP2D6;CYP2W1;CYP2C9 |
| Estrogen metabolism | COMT;CYP1B1;CYP1A1;ARSD;ARSE;NQO1 |
| Fatty Acid Omega Oxidation | CYP4A11;ADH1B;ADH6;CYP2D6;CYP2E1;ADH1C;ADH7;CYP2A6;ADH4 |
CYP1A1 has several biochemical functions, for example, aromatase activity, demethylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A1 itself. We selected most functions CYP1A1 had, and list some proteins which have the same functions with CYP1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aromatase activity | CYP4Z1;CYP1B1;CYP2J6;CYP2D6;CYP3A5;CYP2C54;CYP2D9;CYP2J2;CYP2C37 |
| demethylase activity | CYP3A41A;CYP1A2;KDM1A;CYP3A41B;CYP1A1;ALKBH4 |
| enzyme binding | BACE1;CA;CYP2C19;CSF3;GNB2L1;JUN;CD4;PARK2;DVL1 |
| flavonoid 3-monooxygenase activity | |
| heme binding | PGRMC2;PTGS2A;Adgb;EPX;CYP2J2;CYP2A4;CYP27C1;CYP4A11;CYP2A6 |
| iron ion binding | CYP2D9;CYP2P6;ALOX15;CYP3A7;LEPREL1;ALOX12E;CYP4V2;FAM125B;P4HTM |
| monooxygenase activity | CYP2C55;CYP46A1.2;YWHAE1;CYP2K6;TH2;CYP2AA8;CYP4T8;CYP1A4;CYP2C18 |
| oxidoreductase activity | CYP2AA3;RYROXD1;CREG1;CYP4F14;DHRS3B;BCO2L;DMGDH;ALOX5A;DHRS7CA |
| oxidoreductase activity, acting on diphenols and related substances as donors | |
| oxygen binding | HBA2;HBZ;CYP2A7;HBA1;HBQ1;HBD;BA1;CYP2A12;HBAA |
| protein binding | CTNNB2;FAM53C;TRIM16;H2AFZ;HIPK2;KHK;UQCC1;KIAA1279;HEBP2 |
| steroid hydroxylase activity | CYP2D10;CYP2AA12;CYP46A1.2;CYP2P10;CYP2K16;CYP2AD6;CYP2A6;CYP2X8;CYP2AA7 |
| vitamin D 24-hydroxylase activity | FAM84B;CYP1A1;CYP3A4 |
CYP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A1.
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