Recombinant Human CYP1A1 Protein, GST-tagged

• Cat.No.: CYP1A1-2244H
• Product Overview: Human CYP1A1 full-length ORF ( AAH23019, 1 a.a. - 512 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 82.06 kDa
• AA Sequence: MLFPISMSATEFLLASVIFCLVFWV IRASRPQVPKGLKNPPGPWGWPLIG HMLTLGKNPHLALSRMSQQYGDVLQ IRIGSTPVVVLSGLDTIRQALVRQG DDFKGRPDLYTFTLISNGQSMSFSP DSGPVWAARRRLAQNGLKSFSIASD PASSTSCYLEEHVSKEAEVLISTLQ ELMAGPGHFNPYRYVVVSVTNVICA ICFGRRYDHNHQELLSLVNLNNNFG EVVGSGNPADFIPILRYLPNPSLNA FKDLNEKFYSFMQKMVKEHYKTFEK GHIRDITDSLIEHCQEKQLDENANV QLSDEKIINIVLDLFGAGFDTVTTA ISWSLMYLVMNPRVQRKIQEELDTV IGRSRRPRLSDRSHLPYMEAFILET FRHSSFVPFTIPHSTTRDTSLKGFY IPKGRCVFVNQWQINHDQKLWVNPS EFLPERFLTPDGAIDKVLSEKVIIF GMGKRKCIGETIARWEVFLFLAILL QRVEFSVPLGVKVDMTPIYGLTMKH ACCEHFQMQLRS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [ Homo sapiens ]
• Official Symbol: CYP1A1
• Synonyms: CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; AHH; AHRR; CYP1; P1-450; P450-C
• Gene ID: 1543
• mRNA Refseq: NM_000499
• Protein Refseq: NP_000490
• MIM: 108330
• UniProt ID: P04798