CYP2C19

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 19

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

  • Synonyms

    CYP2C19;cytochrome P450, family 2, subfamily C, polypeptide 19;CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19;cytochrome P450 2C19;CPCJ;P450IIC19;CYPIIC17;CYPIIC19;cytochrome P450-11A;cytochrome P450-254C;cyto

Recombinant Proteins

  • Human
  • Cynomolgus
  • E.coli
  • S.Cerevisiae
  • P.pastoris
  • Insect Cells
  • HEK293
  • Protein Conjugation
  • Mammalian Cells
  • Non
  • DDK
  • Myc
  • His
  • Flag

    Involved Pathway

    CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways CES1,SDHB,OCRL,LPCAT4,POLD2,GPIA,CTPS2,HMBSB,NDUFS8A,ALG1
    Cytochrome P450 - arranged by substrate type FDX1,CYP2E1,CYP2K22,CYP2C9,CYP2V1,CYP11B2,CYP2K17,CYP3A5,CYP2A13,FAM84B
    Biological oxidations CYP2S1,SULT2ST1,CYP3A4,SLC26A2,CYP2A7,CYP2A13,GSTK1,Sult2a6,SLC35B2,SLC35D1A
    Linoleic acid metabolism CYP2C45,PLA2G2D,PLA2G6,CYP2J6,CYP2C38,CYP2C50,ALOX15,PLA2G4A,PLA2G3,PLA2G5
    Drug metabolism - cytochrome P450 ADH5,ADH2-1,CYP3A5,CYP2C9,ADH6,CYP2B6,CYP2C8,ADH1C,GSTO2,ADH1B
    CYP2E1 reactions CYP2F1,CYP2C9,CYP2C8,CYP2A7,CYP2S1,CYP2A6,CYP2E1,CYP2D6,CYP2Y3,CYP2A13
    Arachidonic acid metabolism CYP2J6,PTGS2,CYP1A2,FAM213B,CYP2B19,PTGES2,PLA2G4D,CYP2P10,CYP2C37,PTGS1
    Chemical carcinogenesis GSTT2B,UGT1A6A,GSTA2,NAT2,ALDH3B2,CYP3A4,ADH6,CCBL1,CYP1B1,ADH7

    Protein Function

    CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity,(S)-limonene 6-monooxygenase activity,(S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.

    Function Related Protein
    monooxygenase activity MICAL2,CYP4F18,CYP3A25,CYP1A2,TH2,CYP39A1,CYP2B6,CYP2D6,CYP20A1,FAM84B
    enzyme binding SELS,PLCE1,TRP53,CDC20,NOS1,RAD9,TSPYL1,HOXA9,ATP6AP2,UGT1A9
    (S)-limonene 6-monooxygenase activity CYP2C9,CYP2C8
    steroid hydroxylase activity CYP2F2,CYP46A1.3,CYP2D6,CYP2X10.2,CYP2C39,CYP46A1,CYP2J6,CYP2AA2,CYP2X7,CYP2K16
    (R)-limonene 6-monooxygenase activity CYP2C9,CYP2C8
    iron ion binding HBE1,CYP2K18,HBA1,LEPREL1,BA1,CYP4V2,CYP2J5,ALOX5B.2,CYP4T8,TPH1B
    oxidoreductase activity TDO2A,CYP2F2,KDM1A,IYD,ALOX8,CYP3A25,HSD17B12A,SPRB,CYP2AA12,CYP2AA2
    arachidonic acid epoxygenase activity CYP2C50,CYP2C54,CYP2D10,CYP2C9,CYP2A13,CYP2C18,CYP2AD2,CYP2D26,CYP2B6,CYP4F12
    (S)-limonene 7-monooxygenase activity CYP2C8,CYP2C9

    Interacting Protein

    CYP2C19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C19.

    Resources

    References

    • Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
    • Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).

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