CYP2C19

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CYP2C19

Official Full Name cytochrome P450, family 2, subfamily C, polypeptide 19
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Synonyms CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19; cytochrome P450 2C19; CPCJ; P450IIC19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cyto
    • Species :
    • Cynomolgus
    • Human
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • P.pastoris
    • S.cerevisiae
    • Tag :
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2C19-16H Recombinant Human CYP2C19 protein, Active P.pastoris N/A
    Human CYP2C19-33H Recombinant Human CYP2C19 Protein E.coli
    Human CYP2C19-536H Recombinant Human CYP2C19 Insect Cell N/A
    Human CYP2C19-538H Recombinant Human CYP2C19, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2C19-540H Recombinant Human CYP2C19 (I331V) E.coli N/A
    Human CYP2C19-541H Recombinant Human CYP2C19 E.coli N/A
    Human CYP2C19-542H Recombinant Human CYP2C19 S.cerevisiae N/A
    Human CYP2C19-75H Recombinant Human CYP2C19 Protein E. coli
    Cynomolgus CYP2C19-126C Recombinant Cynomolgus CYP2C19 Protein E. coli
    Kit-0908 CYP2C19 Blue Screening Kit N/A
    Kit-2124 Cytochrome P450 2C19 Fluorometric Activity Assay Kit N/A
    Kit-2125 Cytochrome P450 2C19 Inhibitor Screening Kit N/A

    CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism GPX7; CYP4A14; PTGES; ALOX5AP; CYP2P9; PLA2G4D; CYP2U1; GGTLC1; CYP2J2; CYP2E1
    Biological oxidations CYP7A1; CYP24A1; GSTO2; ABHD14B; CYP1B1; GGT6; CES1; CYP19A1; BPNT1; CYP1A2
    CYP2E1 reactions CYP2A13; CYP2Y3; CYP2C19; CYP2B6; CYP2E1; CYP2S1; CYP2A7; CYP2C8; CYP2F1; CYP2A6
    Chemical carcinogenesis UGT1A6A; UGT2A3; CYP3A5; SULT2A1; GSTM6; Nat3; ALDH1A3; UGT1A1; GSTP1; ALDH3B1
    Cytochrome P450 - arranged by substrate type CYP2V1; CYP19A1; CYP2N13; CYP2AD6; CYP3C4; CYP2C9; CYP2U1; FDX1L; CYP2B6; CYP46A1
    Drug metabolism - cytochrome P450 CYP2B6; CYP2E1; ADH6; ADH5; GSTO2; ADH1A; GSTK1; CYP2A6; CYP2C9; ADH1B
    Linoleic acid metabolism CYP2C70; PLB1; CYP2C55; CYP2C45; PLA2G2F; CYP3A41B; CYP2P8; PLA2G4D; PLA2G1B; CYP2C9
    Metabolic pathways PDHA2; TSTA3; COASY; ATP6V0CB; NAT; PLCB1; HSD17B6; COX6A1; AKR1C4; UQCRQ

    CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.

    Function Related Protein
    (R)-limonene 6-monooxygenase activity CYP2C19; CYP2C8; CYP2C9
    (S)-limonene 6-monooxygenase activity CYP2C9; CYP2C19; CYP2C8
    (S)-limonene 7-monooxygenase activity CYP2C9; CYP2C19; CYP2C8
    arachidonic acid epoxygenase activity CYP2AD2; CYP2C18; CYP2A4; CYP2C8; CYP2A6; CYP4A11; CYP2C54; CYP2C38; CYP2C70; CYP2C19
    enzyme binding PICK1; SPDL1; RCOR2; RPA3; PRKCE; ZNHIT6; MDM4; CSF3; LGALS9; JUND
    heme binding NENF; SUOX; ABCB6; CYP2F1; TDO2; HBA-A2; CYP2AA1; CYP2Y3; Adgb; PTGS2A
    iron ion binding FDX1; CYP11B2; TMEM195; CYP4T8; CYP7A1; SC5D; HBAE3; ALOX12B; CYP2K6; CYP2A6
    monooxygenase activity YWHAQA; CYP2X9; CYP2F2; CYP26C1; CYP2F1; CYP4A10; CYP2AD2; CYP4A12A; CYP17A2; CYP8B2
    oxidoreductase activity DHRS13; HPDA; CYP1D1; SNCA; HSD3B5; SCCPDHB; MICAL2B; ALDH9A1B; CYP3C4; CYP2C54
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2AA9; CYP2AA8; CYP2AA3; CYP2N13; CYP2AD6; CYP2K6; CYP2K16; CYP2E1; CYP2C70; CYP2X8
    oxygen binding CYP2AA3; CYP2C9; HBM; NGB; CYGB; CYP2C39; CYP2W1; CYP2F2; HBD; HBG1
    steroid hydroxylase activity CYP2D6; CYP2X7; BRSK2; CYP2AA2; CYP2C8; CYP2AA3; CYP46A1; CYP2D26; CYP2K6; CYP2D10

    CYP2C19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C19.

    Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
    Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).

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