CYP2E1
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Official Full Name
cytochrome P450, family 2, subfamily E, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] -
Synonyms
CYP2E1;cytochrome P450, family 2, subfamily E, polypeptide 1;CPE1;CYP2E;P450-J;P450C2E;cytochrome P450 2E1;CYPIIE1;cytochrome P450-J;microsomal monooxygenase;xenobiotic monooxygenase;4-nitrophenol 2-hydroxylase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Human and Yeast
- Mouse
- Pig
- S.Cerevisiae
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- Yeast
- Non
- His
- GST
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | GGTLC1,ACSM1,UGT1B2,CYP2C19,ABHD10,DPEP1,CYP2AD2,SULT1ST6,FAM84B,ADH4 |
| Chemical carcinogenesis | CYP3A5,CYP3A7,MGST1,CYP2C54,CYP2C38,CYP2C55,CYP2C8,GSTO2,UGT1A7C,CYP3A41B |
| Cytochrome P450 - arranged by substrate type | CYP2K19,CYP2K17,CYP3A7-CYP3AP1,CYP46A1,CYP4A11,CYP4F11,CYP2K8,POMCB,CYP2K22,CYP2N13 |
| Drug metabolism - cytochrome P450 | ADH6,CYP2C19,ADH4,ADH1A,ADH7,CYP3A5,GSTO2,CYP2D6,ADH1B,CYP2C8 |
| Fatty Acid Omega Oxidation | CYP2A6,ADH1B,ADH1A,ADH1C,ADH7,CYP1A1,ADH6,CYP2D6,CYP4A11,ADH4 |
| Arachidonic acid metabolism | PLA2G4AA,PTGDSA,PLA2G12B,PLA2G2E,PTGS2B,CYP1B1,ALOX8,CYP4A11,CYP2P10,HPGDS |
| CYP2E1 reactions | CYP2B6,CYP2C9,CYP2D6,CYP2Y3,CYP2F1,CYP2S1,CYP2C8,CYP2A13,CYP2A6,CYP2C19 |
| Folate-Alcohol and Cancer Pathway | ALDH1L1 |
Protein Function
CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity,enzyme binding,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | P4HA1A,HBA-X,CYP2C50,PTGIS,P3H2,CYP4A11,P4HA2,CH25H,HBB-B2,CYP3C4 |
| monooxygenase activity | CYP3C4,CYP51,CYP2J5,TH2,CYP1D1,CYP3A43,CYP2P6,CYP11C1,CYP20A1,CYP2C54 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2W1,CYP2AD3,CYP2C9,CYP2P9,CYP2F2,CYP2D9,CYP2S1,CYP2AA6,CYP1B1,CYP2A7 |
| oxidoreductase activity | CYP2AA12,PYCR1B,GCDHB,SDR39U1,TDH,CYP2AA2,SCDB,DHRS4L2,CYP2D10,MICAL2 |
| enzyme binding | HIST1H2AD,YES1,TNKS2,UGT1A3,KALRN,ATXN10,CAV1,PRKCE,TMBIM6,HIST1H2AE |
| steroid hydroxylase activity | CYP21A2,CYP2A7,CYP2AA3,CYP2C39,CYP2AA9,CYP2R1,CYP2P7,CYP2AA8,CH25H,CYP2F1 |
| oxygen binding | CYP3A5,HBA1,CYP1A1,CYP2U1,CYP2AA2,CYP2C38,HBAD,CYP2AA1,HBQ1,CYP2D26 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | NDOR1,CYP11B2,CYP4F18,MTRR,MICAL2,CYP4F11,CYP4F2,POR,COQ6,CYP11B1 |
| heme binding | CYP1A1,CYP1A2,CYP2D26,PTGS2,CYP4F18,CYP4T8,CYP2C54,PTGS2A,CYP4A12A,CYP2AA9 |
Interacting Protein
CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.
MAFG;CLU;PTN;ECHS1;RPL13A;GATM;NMI;ABCA5;AGXT2;LAMC3
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References
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
- Safari, S; Motavaf, M; et al. Hepatotoxicity of Halogenated Inhalational Anesthetics. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2014).
