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CYR61

  • Official Full Name

    cysteine-rich, angiogenic inducer, 61

  • Overview

    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
  • Synonyms

    CYR61; cysteine-rich, angiogenic inducer, 61; CCN1; GIG1; IGFBP10; protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYR61-531H Active Recombinant Human CYR61 E.coli N/A
Human CYR61-895H Active Recombinant Human CYR61 Protein, Fc Chimera CHO Fc
Human CYR61-27830TH Recombinant Human CYR61, His-tagged E.coli His
Human CYR61-933H Recombinant Human CYR61 protein E.coli N/A 357
Human CYR61-2295H Recombinant Human CYR61 Protein, GST-tagged Wheat Germ GST
Human CYR61-896H Recombinant Human CYR61 protein, Fc-tagged HEK293 Fc Thr25-Asp381
Human CYR61-7097HCL Recombinant Human CYR61 293 Cell Lysate HEK293 N/A
Human CYR61-3656H Recombinant Human CYR61 protein, GST-tagged E.coli GST 165-239 aa
Human CYR61-436H Recombinant Human CYR61 Protein, His-tagged E.coli His Leu178~Asp381
Human CYR61-2797H Recombinant Human CYR61 protein, His-SUMO-tagged E.coli His-SUMO 25-381aa
Human CYR61-2486HF Recombinant Full Length Human CYR61 Protein, GST-tagged In Vitro Cell Free System GST 381 amino acids
Mouse CYR61-4246M Recombinant Mouse CYR61 Protein Mammalian Cell His
Mouse Cyr61-4247M Recombinant Mouse Cyr61 Protein, His-tagged E.coli His Asp176~Asp379
Mouse Cyr61-437M Recombinant Mouse Cyr61 Protein, His-tagged E.coli His Asp176~Asp379
Mouse Cyr61-2798M Recombinant Mouse Cyr61 protein, His-tagged E.coli His 25-379aa
Mouse CYR61-2165M-B Recombinant Mouse CYR61 Protein Pre-coupled Magnetic Beads HEK293
Mouse CYR61-1374M Recombinant Mouse CYR61 Protein (25-379 aa), His-tagged Yeast His 25-379 aa
Mouse CYR61-2165M Recombinant Mouse CYR61 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CYR61-1759R Recombinant Rat CYR61 Protein Mammalian Cell His
Rat CYR61-1418R-B Recombinant Rat CYR61 Protein Pre-coupled Magnetic Beads HEK293
Rat CYR61-1418R Recombinant Rat CYR61 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CYR61-5179Z Recombinant Zebrafish CYR61 Mammalian Cell His
Chicken CYR61-3205C Recombinant Chicken CYR61 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYR61 Related Articles
  • CYR61 Related Research Area

CYR61 involved in several pathways and played different roles in them. We selected most pathways CYR61 participated on our site, such as Hypertrophy Model, Oncostatin M Signaling Pathway, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYR61 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hypertrophy ModelADAM10A;DUSP14;MSTNB;MSTN;IFRD1;CYR61;JUND;MYOG;WDR1
Oncostatin M Signaling PathwayJUND;CYR61
Regulation of Wnt-mediated beta catenin signaling and target gene transcriptionSALL4;AES;CYR61;TCF4;KRT1;TLE2;TLE4;HBP1;MYOG
RhoA signaling pathwayCYR61;DIAPH1;ACTA1;MKL1
amb2 Integrin signalingHP;LPA;NIPAL1;CYR61;ELANE;MST1;MST1R

CYR61 has several biochemical functions, for example, extracellular matrix binding, heparin binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYR61 itself. We selected most functions CYR61 had, and list some proteins which have the same functions with CYR61. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix bindingITGB3;ITGA2B;CYR61;VTN;TGFBI;DCN;ITGAV;SPP1;SPARC
heparin bindingSAA1;BMP4;NELL2;PF4;ABP1;CYR61;CHRD;SLIT3;SMOC2
insulin-like growth factor bindingESM1;IGFBP7;WISP1;IGFBP2A;HTRA1B;KAZALD3;WISP1B;IGFBP2B;IGFBP5A
integrin bindingPXN;CIB2;ITGB1;NIPAL1;THY1;SFRP2;LAMB2;CD151;FERMT3

CYR61 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYR61 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYR61.

ZWINT; Mis12; recB; recN; MYC; CNTROB

Park, YS; Hwang, S; et al. CCN1 Secreted by Tonsil-Derived Mesenchymal Stem Cells Promotes Endothelial Cell Angiogenesis via Integrin alpha(v)beta(3) and AMPK. JOURNAL OF CELLULAR PHYSIOLOGY 230:140-149(2015).
Chen, CY; Su, CM; et al. CCN1 Induces Oncostatin M Production in Osteoblasts via Integrin-Dependent Signal Pathways. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What did recent research on CYR61 find? 10/09/2021

Recent studies have found that CYR61 plays an important role in tumor development and metastasis, especially in cancers such as non-small cell lung cancer, breast cancer, gastric cancer, and colorectal cancer.

Which drugs can inhibit the expression level of CYR61? 03/03/2021

There are currently no drugs specifically targeting CYR61, but some anti-tumor drugs can inhibit the expression level of CYR61, such as chemotherapy drugs and targeted therapy drugs.

What is the relationship between the level of CYR61 expression and patient survival? 02/08/2021

Studies have shown that high levels of CYR61 expression are associated with decreased patient survival, suggesting that it may be used as a biomarker to predict patient survival.

What signaling pathways is CYR61 involved in? 12/26/2020

CYR61 is involved in a variety of signaling pathways, including Wnt, MAPK, ERK, and PI3K.

What is the significance of regulating the expression level of CYR61 for the treatment of diseases? 06/03/2020

Regulating the expression level of CYR61 is of great significance for the treatment of diseases, especially for the treatment of cancer, and can slow down the growth and spread of tumors by inhibiting the expression level of CYR61.

How can the relationship between CYR61 expression levels and disease risk be assessed? 02/24/2020

The relationship between CYR61 expression levels and disease risk can be assessed by immunohistochemistry or western blot analysis of the patient's tissue samples.

Customer Reviews (3)

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Reviews
07/18/2022

    It has good effect and stability in gene expression regulation.

    06/04/2022

      Will not interact with other drugs, will not affect.

      07/20/2021

        The application performance is stable in common colorimetric reactions.

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