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Official Full Name cysteine-rich, angiogenic inducer, 61
Background The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Synonyms CYR61; cysteine-rich, angiogenic inducer, 61; CCN1; GIG1; IGFBP10; protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYR61-2295H Recombinant Human CYR61 Protein, GST-tagged Wheat Germ GST
    Human CYR61-27830TH Recombinant Human CYR61, His-tagged E.coli His
    Human CYR61-436H Recombinant Human CYR61 Protein, His-tagged E.coli His
    Human CYR61-531H Recombinant Human CYR61 E.coli N/A
    Human CYR61-7097HCL Recombinant Human CYR61 293 Cell Lysate HEK293 N/A
    Human CYR61-895H Recombinant Human CYR61 Protein, Fc Chimera CHO Fc
    Human CYR61-896H Recombinant Human CYR61 protein, Fc-tagged HEK293 Fc
    Human CYR61-933H Recombinant Human CYR61 protein E.coli N/A
    Mouse CYR61-1374M Recombinant Mouse CYR61 Protein (25-379 aa), His-tagged Yeast His
    Mouse CYR61-4246M Recombinant Mouse CYR61 Protein Mammalian Cell His
    Mouse Cyr61-4247M Recombinant Mouse Cyr61 Protein, His-tagged E.coli His
    Mouse Cyr61-437M Recombinant Mouse Cyr61 Protein, His-tagged E.coli His
    Rat CYR61-1759R Recombinant Rat CYR61 Protein Mammalian Cell His
    Chicken CYR61-3205C Recombinant Chicken CYR61 Mammalian Cell His
    Zebrafish CYR61-5179Z Recombinant Zebrafish CYR61 Mammalian Cell His

    CYR61 involved in several pathways and played different roles in them. We selected most pathways CYR61 participated on our site, such as Hypertrophy Model, Oncostatin M Signaling Pathway, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYR61 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hypertrophy Model ANKRD1; ZEB1B; MSTNB; CYR61; MYOG; IFRD1; ADAM10A; MSTN; JUND; WDR1
    Oncostatin M Signaling Pathway JUND; CYR61
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription TNIK; HBP1; CBY1; IGF2BP1; TLE1; KRT1; TCF4; TLE4; T; TLE2
    RhoA signaling pathway DIAPH1; CYR61; ACTA1; MKL1
    amb2 Integrin signaling HP; MST1; MST1R; CYR61; NIPAL1; LPA; ELANE

    CYR61 has several biochemical functions, for example, extracellular matrix binding, heparin binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYR61 itself. We selected most functions CYR61 had, and list some proteins which have the same functions with CYR61. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix binding SID4; SPOCK2; CD248; SPP1; ITGB3; CYR61; ITGAV; ITGA2B; SPARC; VTN
    heparin binding HDGF; FGF9; SLIT2; FGFR1A; THBS2; SELP; CTGF; NRP1; RSPO4; CXCL13
    insulin-like growth factor binding IGFBP1B; KAZALD2; NOV; KAZALD1; IGFBP5A; CTGF; IGF1RA; IGFBP5B; IGFBP2A; HTRA4
    integrin binding PXN; ADAM10; SEMA7A; MFGE8; S1PR2; VTN; ADAM23; LAMB1; CTGFB; NF2

    CYR61 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYR61 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYR61.

    ZWINT; Mis12; recB; recN; MYC; CNTROB

    Park, YS; Hwang, S; et al. CCN1 Secreted by Tonsil-Derived Mesenchymal Stem Cells Promotes Endothelial Cell Angiogenesis via Integrin alpha(v)beta(3) and AMPK. JOURNAL OF CELLULAR PHYSIOLOGY 230:140-149(2015).
    Chen, CY; Su, CM; et al. CCN1 Induces Oncostatin M Production in Osteoblasts via Integrin-Dependent Signal Pathways. PLOS ONE 9:-(2014).

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