CYR61
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Official Full Name
cysteine-rich, angiogenic inducer, 61
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Overview
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] -
Synonyms
CYR61; cysteine-rich, angiogenic inducer, 61; CCN1; GIG1; IGFBP10; protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- Fc
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CYR61 Related Articles
- CYR61 Related Research Area
CYR61 involved in several pathways and played different roles in them. We selected most pathways CYR61 participated on our site, such as Hypertrophy Model, Oncostatin M Signaling Pathway, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYR61 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hypertrophy Model | ADAM10A;DUSP14;MSTNB;MSTN;IFRD1;CYR61;JUND;MYOG;WDR1 |
Oncostatin M Signaling Pathway | JUND;CYR61 |
Regulation of Wnt-mediated beta catenin signaling and target gene transcription | SALL4;AES;CYR61;TCF4;KRT1;TLE2;TLE4;HBP1;MYOG |
RhoA signaling pathway | CYR61;DIAPH1;ACTA1;MKL1 |
amb2 Integrin signaling | HP;LPA;NIPAL1;CYR61;ELANE;MST1;MST1R |
CYR61 has several biochemical functions, for example, extracellular matrix binding, heparin binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYR61 itself. We selected most functions CYR61 had, and list some proteins which have the same functions with CYR61. You can find most of the proteins on our site.
Function | Related Protein |
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extracellular matrix binding | ITGB3;ITGA2B;CYR61;VTN;TGFBI;DCN;ITGAV;SPP1;SPARC |
heparin binding | SAA1;BMP4;NELL2;PF4;ABP1;CYR61;CHRD;SLIT3;SMOC2 |
insulin-like growth factor binding | ESM1;IGFBP7;WISP1;IGFBP2A;HTRA1B;KAZALD3;WISP1B;IGFBP2B;IGFBP5A |
integrin binding | PXN;CIB2;ITGB1;NIPAL1;THY1;SFRP2;LAMB2;CD151;FERMT3 |
CYR61 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYR61 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYR61.
ZWINT; Mis12; recB; recN; MYC; CNTROB
- Q&As
- Reviews
Q&As (6)
Ask a questionRecent studies have found that CYR61 plays an important role in tumor development and metastasis, especially in cancers such as non-small cell lung cancer, breast cancer, gastric cancer, and colorectal cancer.
There are currently no drugs specifically targeting CYR61, but some anti-tumor drugs can inhibit the expression level of CYR61, such as chemotherapy drugs and targeted therapy drugs.
Studies have shown that high levels of CYR61 expression are associated with decreased patient survival, suggesting that it may be used as a biomarker to predict patient survival.
CYR61 is involved in a variety of signaling pathways, including Wnt, MAPK, ERK, and PI3K.
Regulating the expression level of CYR61 is of great significance for the treatment of diseases, especially for the treatment of cancer, and can slow down the growth and spread of tumors by inhibiting the expression level of CYR61.
The relationship between CYR61 expression levels and disease risk can be assessed by immunohistochemistry or western blot analysis of the patient's tissue samples.
Customer Reviews (3)
Write a reviewIt has good effect and stability in gene expression regulation.
Will not interact with other drugs, will not affect.
The application performance is stable in common colorimetric reactions.
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