dck
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  • Official Full Name
  • deoxycytidine kinase
  • Background
  • Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity.
  • Synonyms
  • DCK; deoxycytidine kinase; DCK protein; DCK_HUMAN; OTTHUMP00000160356; OTTHUMP00000219118; OTTHUMP00000219119; deoxynucleoside kinase
Cat.#:DCK-2390HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCK Protein, GST-tagged
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Cat.#:DCK-27365THTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human DCK Protein, His-tagged
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Cat.#:DCK-11853HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCK, GST-tagged
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Cat.#:DCK-185HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCK protein
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Cat.#:DCK-795HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Deoxycytidine Kinase, His-tagged
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Cat.#:DCK-796HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DCK, His-tagged
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Cat.#:DCK-857HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human DCK Protein, DDK-tagged
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Cat.#:DCK-4349MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DCK Protein
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Cat.#:DCK-1793RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DCK Protein
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Cat.#:DCK-1191RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DCK Protein, His-tagged
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Cat.#:DCK-1591CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DCK
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Cat.#:DCK-1626ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DCK
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Cat.#:DCK-2265BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis DCK protein, His-tagged
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Cat.#:DCK-7051HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DCK 293 Cell Lysate
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Cat.#:Kit-0879Tag:
Source (Host):Species:
Product namedCK Screening Assay Kit
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Involved Pathway

DCK involved in several pathways and played different roles in them. We selected most pathways DCK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
HGD; GPAA1; MECR; POLR3H; ALDH1B1; PIGK; SAT1A.1; PLCH1; B3GNT5A; NDUFS7
Metabolism
SLC35D1A; CYP24A1; ADSSL1; MED23; NFYAL; AKR1B15; DPYS; AQP1A.1; SLC16A1; IDO2
Metabolism of nucleotides
ADSSL1; NUDT15; AK7A; AK8; DCK; NUDT5; NUDT18; ADSL; AK7; PNP5B
Purine metabolism
URAD; NME7; PDE8B; AK1; Adcy4; PRPS2; GUCY1B3; PRUNE; RRM2B; NUDT5
Purine salvage
DGUOK; PNP5B; ADAL; TM9SF1; ADA; DCK; ADK
Pyrimidine metabolism
RRM2B; NT5M; NME1-NME2; POLD1; TK2; DPYDA.1; POLR2H; UCK2B; POLR3K; TK1
Pyrimidine salvage reactions
DCK; UPP2
RB in Cancer
SMARCA2; ANLN; FAF1; RABIF; HLTF; TOP2A; RBP1; PRMT2; HMGB2; DCK

Protein Function

DCK has several biochemical functions, for example, ATP binding, deoxycytidine kinase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCK itself. We selected most functions DCK had, and list some proteins which have the same functions with DCK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein OAS1B; EEF2K; UBE2E2; CSNK1A1L; DYNC1LI1; ACVR1B; UPF1; SRPK3; ATP11A; RAD54B
Function deoxycytidine kinase activity
Related Protein DCK; TK2
Function drug binding
Related Protein P2RX1; SETD6; CHRNB4; GPR30; PPARA; HTR1B; PIGC; FASN; NAMPT; CHRM3
Function nucleoside kinase activity
Related Protein DGUOK; UCK2; UCK2A; TK1; DCK; UCK1; UCK2B
Function protein homodimerization activity
Related Protein IGJ; CECR1; HARS2; MIXL1; OXCT1; CHMP4A; PVR; BOKA; HSPB6; JUP

Interacting Protein

DCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCK here. Most of them are supplied by our site. Hope this information will be useful for your research of DCK.
MED19; TFEC; RXRG; GOLM1; DDX19B; bosutinib

DCK Related Articles

Zhuang, XM; Deng, JT; et al. Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes. ACTA PHARMACOLOGICA SINICA 32:1276-1284(2011).
Fong, WF; Shen, XL; et al. Methoxylation of 3 ',4 '-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY 16:3694-3703(2008).