DCK

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DCK

Official Full Name deoxycytidine kinase
Background Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity.
Synonyms DCK; deoxycytidine kinase; DCK protein; DCK_HUMAN; OTTHUMP00000160356; OTTHUMP00000219118; OTTHUMP00000219119; deoxynucleoside kinase
    • Species :
    • Bacillus subtilis
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli or Yeast
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DCK-11853H Recombinant Human DCK, GST-tagged E.coli GST
    Human DCK-185H Recombinant Human DCK protein E.coli N/A
    Human DCK-2390H Recombinant Human DCK Protein, GST-tagged Wheat Germ GST
    Human DCK-27365TH Recombinant Human DCK Protein, His-tagged E.coli His
    Human DCK-7051HCL Recombinant Human DCK 293 Cell Lysate HEK293 N/A
    Human DCK-734H Recombinant Human DCK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DCK-795H Recombinant Human Deoxycytidine Kinase, His-tagged E.coli His
    Human DCK-796H Recombinant Human DCK, His-tagged Sf9 Insect Cell His
    Human DCK-857H Recombinant Human DCK Protein, DDK-tagged Sf9 Insect Cell DDK
    Mouse Dck-2472M Recombinant Mouse Dck Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse DCK-4349M Recombinant Mouse DCK Protein Mammalian Cell His
    Rat DCK-1793R Recombinant Rat DCK Protein Mammalian Cell His
    Rhesus Macaque DCK-1191R Recombinant Rhesus monkey DCK Protein, His-tagged Mammalian Cell His
    Chicken DCK-1591C Recombinant Chicken DCK Mammalian Cell His
    Zebrafish DCK-1626Z Recombinant Zebrafish DCK Mammalian Cell His
    Bacillus subtilis DCK-2265B Recombinant Bacillus subtilis DCK protein, His-tagged E. coli or Yeast His
    Kit-0879 dCK Screening Assay Kit N/A

    DCK involved in several pathways and played different roles in them. We selected most pathways DCK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways FAH; AKR1C3; UQCR11; ACSL1A; COX7B2; HMGCS2; ALDOCB; DEGS1; GCSH; CERS1
    Metabolism CHST9; GCHFR; LMF1; NAGS; BCHE; LYRM4; PAICS; AFMID; SLC5A2; LPA
    Metabolism of nucleotides AK7A; DUT; NUDT1; DCK; DPYDA.1; PROZA; AK8; ADAL; UPP2; DPYD
    Purine metabolism PNP; CANT1A; TWISTNB; PDE9A; DCK; RRM2B; URAD; PDE2A; NT5C3A; IMPDH1B
    Purine salvage PNP5B; ADAL; TM9SF1; ADK; ADA; DCK; DGUOK
    Pyrimidine metabolism NT5C3B; UCK2A; POLR3A; POLR2EB; ENTPD6; TXNRD1; NT5C1BA; UPP2; POLR2I; POLR3K
    Pyrimidine salvage reactions UPP2; DCK
    RB in Cancer FAF1; ANLN; PRMT2; SMARCA2; DCK; RABIF; RBP1; HMGB2; HLTF; TOP2A

    DCK has several biochemical functions, for example, ATP binding, deoxycytidine kinase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCK itself. We selected most functions DCK had, and list some proteins which have the same functions with DCK. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DALRD3; LATS1; ACTC1A; PKN3; TRAP1; HSP70; FYNB; MAP2K5; GMPS; UBE2M
    deoxycytidine kinase activity TK2; DCK
    drug binding CHRNB3; FOLR2; HTR2B; TOP2A; IL2RA; PIGC; CHRNA3; PYGM; SFRP1; PPARD
    nucleoside kinase activity UCK1; TK1; DCK; UCK2; UCK2A; UCK2B; DGUOK
    protein homodimerization activity TSG101; DMRTC1C2; PVRL2L; TBX1; TFAP2A; ABCB10; IDH1; NAGA; ZFP365; MID2

    DCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCK here. Most of them are supplied by our site. Hope this information will be useful for your research of DCK.

    MED19; TFEC; RXRG; GOLM1; DDX19B; bosutinib

    Zhuang, XM; Deng, JT; et al. Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes. ACTA PHARMACOLOGICA SINICA 32:1276-1284(2011).
    Fong, WF; Shen, XL; et al. Methoxylation of 3 ',4 '-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY 16:3694-3703(2008).

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