Active Recombinant Full Length Human deoxycytidine kinase Protein, His tagged

• Cat.No.: DCK-07HFL
• Product Overview: Active Recombinant Full Length Human deoxycytidine kinase Protein with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-260 aa
• Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
• Form: Yellowish amorphous lyophilized powder
• CAS No.: 9039-45-6
• Bio-activity: Specific Activity: 48 U/mg Protein Activity: 22 U/mg solid
• Unit Definition: One unit of WT human DCK converts 1.0 μmole of dC and ATP to dCMP and ADP per minute at pH 7.5 at 37 centigrade.
• Purity: ≥95% by SDS-PAGE
• Note: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
• Stability: At least 1 year
• Storage: Store it at -20 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: This enzyme powder is PBS based buffer and reconstitute using H2O.

Gene Information

• Gene Name: DCK deoxycytidine kinase [ Homo sapiens (human) ]
• Official Symbol: DCK
• Synonyms: DCK; deoxycytidine kinase; deoxynucleoside kinase; MGC117410; MGC138632
• Gene ID: 1633
• mRNA Refseq: NM_000788
• Protein Refseq: NP_000779
• MIM: 125450
• UniProt ID: P27707