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Official Full Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
Synonyms DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; RIGI; RIG-I; RLR-1; probable ATP-dependent RNA helicase DDX58; RIG-1; RNA helicase RIG-I; DEAD box protein 58; RIG-I-like receptor 1; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX58-10H Recombinant Human DDX58, GST-tagged Wheat Germ GST
    Human DDX58-11H Recombinant Human DDX58, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDX58-2702H Recombinant Human DDX58 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DDX58-452H Recombinant Human DDX58 Protein (1-430 aa), His-tagged E.coli His
    Human DDX58-7000HCL Recombinant Human DDX58 293 Cell Lysate HEK293 N/A
    Human DDX58-7087H Recombinant Human DDX58 protein, His-tagged E.coli His
    Mouse Ddx58-2513M Recombinant Mouse Ddx58 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ddx58-7088M Recombinant Mouse Ddx58 protein, His-tagged E.coli His
    Rhesus Macaque DDX58-1223R Recombinant Rhesus monkey DDX58 Protein, His-tagged Mammalian Cell His

    ddx58 involved in several pathways and played different roles in them. We selected most pathways ddx58 participated on our site, such as NF-kappa B signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ddx58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway LTB; LBP; BCL2; NFKBIA; TNFRSF11A; DDX58; IKBKB; LRDD; Ccl21a; ICAM1
    RIG-I-like receptor signaling pathway TNF; NFKB1; MAPK12B; IFNA5; CASP8; OTUD5; NFKBIB; AZI2; IFNB1; IFNB
    Cytosolic DNA-sensing pathway CCL4; NFKBIAB; POLR3C; TBK1; POLR2K; POLR3G; POLR2EB; ZBP1; IFNA14; RIPK1L
    Hepatitis B CASP8; PCNA; IFNA8; FAS; TP53; NFATC3; STAT3; MAP2K4; CCND1; IL-8
    Measles HSPA1A; CD3E; CD3D; PIK3R3; DDX58; IL12B; IFNGR2; HSPA2; CCNE1; IFNA17; IFIH1
    Influenza A IFNA10; IRF9; IFNA5; TNFRSF10B; PIK3R5; EIF2AK3; KPNA1; IFN-a; NFKBIA; MYD88
    Herpes simplex infection TAF3; TAF5; MED8; EEF1DA; PVRL1B; TTC6; TLR2-2; CSNK2A2; ARNTL1B; SFRS9
    Epstein-Barr virus infection RIPK1; TRAF5; GSK3B; EIF2AK4; HLA-DPB1; CSNK2B; HSPA1L; HDAC4; CD58; HLA-DRB4

    ddx58 has several biochemical functions, for example, ATP binding, double-stranded DNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ddx58 itself. We selected most functions ddx58 had, and list some proteins which have the same functions with ddx58. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP3K2; ETNK1; SLC22A5; HSPA6; TGFBR1B; CHEK2; PLK4; MCCC1; MLH1; ACSM2B
    double-stranded DNA binding YBX1; FEN1; PIN4; NEIL3; MEN1; GTF2H4; MTERF2; ERCC5; PNKP; TDG
    double-stranded RNA binding EIF2C3; ZFP346; ILF2; RNASEN; MBNL1; ADARB1; AGO3; ZNF346; MYH4; TUBB4B
    helicase activity ACTG2; GTF2F2A; DHX32A; CHD9; DHX58; ERCC6L; MOV10B.1; EIF4A2; DNA2; SMARCA5
    identical protein binding GOT2; SH3GL1; GOT2A; SDK2; SNX16; RAF1; JMJD6; STK4; CPT1A; MRAP2
    protein binding BRMS1; ELMO2; HOPX; PKD2L1; TLR3; UROD; TIRAP; FAM122A; ERLEC1; EXOSC4
    single-stranded RNA binding TLR8; POLR2G; RBMX; ZFP36; CBX8; AGO1; DDX58; HMGB1; JMJD6; SNRPC
    zinc ion binding MEP1B; ZRANB3; MLL5; RNF20; ZRANB1; VDR; AJUBA; ALKBH8; TRPS1; RORAB

    ddx58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddx58 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddx58.


    Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
    Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).

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