ddx58

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ddx58

Official Full Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
Synonyms DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; RIGI; RIG-I; RLR-1; probable ATP-dependent RNA helicase DDX58; RIG-1; RNA helicase RIG-I; DEAD box protein 58; RIG-I-like receptor 1; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX58-10H Recombinant Human DDX58, GST-tagged Wheat Germ GST
    Human DDX58-11H Recombinant Human DDX58, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDX58-2702H Recombinant Human DDX58 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DDX58-452H Recombinant Human DDX58 Protein (1-430 aa), His-tagged E.coli His
    Human DDX58-7000HCL Recombinant Human DDX58 293 Cell Lysate HEK293 N/A
    Human DDX58-7087H Recombinant Human DDX58 protein, His-tagged E.coli His
    Mouse Ddx58-2513M Recombinant Mouse Ddx58 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ddx58-7088M Recombinant Mouse Ddx58 protein, His-tagged E.coli His
    Rhesus Macaque DDX58-1223R Recombinant Rhesus monkey DDX58 Protein, His-tagged Mammalian Cell His

    ddx58 involved in several pathways and played different roles in them. We selected most pathways ddx58 participated on our site, such as NF-kappa B signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ddx58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway TRAF2; BCL2L1; MYD88; BCL2; CARD11; PLAU; PIAS4; LBP; GADD45B; XIAP
    RIG-I-like receptor signaling pathway IFNPHI3; IFNA13; DAK; MAPK11; RIPK1; TRIM25; IFNA14; IFNA3; IL-8; IFNA5
    Cytosolic DNA-sensing pathway IKBKB; POLR3B; NFKBIA; ADAR; RIPK1; POLR2K; NFKB1; MB21D1; CXCL10; IL18
    Hepatitis C ARAF; PPP2R2D; IFNA21; EIF2AK2; IFNA7; IFNB1; IFNA1; PIK3R3; NR1H3; OSTN
    Hepatitis B TBK1; STAT1; HBXIP; TGFB1; IKBKB; MAP3K1; MMP9; IRF7; CASP10; CCND1
    Measles CD209A; Il2; IFNA21; CCND2; EIF3H; FCGR2B; OAS2; OAS1A; NFKB1; TNFRSF10C
    Influenza A IL12B; TNFRSF10D; MAP2K2; NXF1; PRSS1; HLA-DRB1; HLA-DQB1; PIK3CA; IFNA2; IRF9
    Herpes simplex infection C3A.1; BLB1; NXF2; IKBKG; CYCSB; HLA-DPB1; IFNA8; IFNG1-2; NFKBIA; IKBKE
    Epstein-Barr virus infection FCER2; PTMA; ICAM1; POLR3K; EIF2AK3; MAPK9; PSMD1; DDX58; HSPB2; POLR3H

    ddx58 has several biochemical functions, for example, ATP binding, double-stranded DNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ddx58 itself. We selected most functions ddx58 had, and list some proteins which have the same functions with ddx58. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX19; RFC5; DDX50; ADRBK1; IARS; CAMK2D1; TSSK5; PDS5B; DICER1; PRKACBA
    double-stranded DNA binding MRE11A; HLF; RAD51L3; CTNNB1; FEN1; DDX11; TDP1; RAD51B; KIN; TP53
    double-stranded RNA binding STAU2; DGCR8; HMGB1; TLR3; MBNL1; OASL; HSPD1; AGO3; ADARB1; OASL1
    helicase activity HLTF; RAD54L; SHPRH; DDX6; HELZ; SETX; SMARCAD1; DHX57; EIF4A1; ERCC6L
    identical protein binding ADORA2A; VEGFA; TRIM23; USP4; AIM2; SCUBE1; PYDC3; LRRK1; SHANK1; SF1
    protein binding RPL23A; ZNF350; CEP57L1; CSF2RB; VCAN; DNAJC10; ZBED3; NFYC; MPZL2B; SH3BP4
    single-stranded RNA binding IFIT5; AGO1; CBX7; LONP1; NXF1; ANXA1; RBMX; A1CF; TLR7; LUZP4
    zinc ion binding CSRP2; MKRN4; ADAMTS15; RC3H1; TRIM44; USP45; SETDB1A; RFFL; MMP16; BARD1

    ddx58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddx58 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddx58.

    MAVS; ZC3HAV1; TRIM25

    Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
    Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).

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