Recombinant Human DDX58 Protein ()
Cat.No. : | DDX58-2070H |
Product Overview : | Recombinant Human DDX58 protein without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. |
Source : | E. coli |
Species : | Human |
Tag : | Tag Free |
Form : | Lyophilized powder/frozen liquid |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [ Homo sapiens (human) ] |
Official Symbol : | DDX58 |
Synonyms : | DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; probable ATP-dependent RNA helicase DDX58; DKFZp434J1111; FLJ13599; retinoic acid inducible gene I; RIG I; RNA helicase RIG I; RIG-1; RNA helicase RIG-I; DEAD box protein 58; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; RIG-I; DKFZp686N19181; |
Gene ID : | 23586 |
mRNA Refseq : | NM_014314 |
Protein Refseq : | NP_055129 |
MIM : | 609631 |
UniProt ID : | O95786 |
Products Types
◆ Recombinant Protein | ||
DDX58-452H | Recombinant Human DDX58 Protein (1-430 aa), His-tagged | +Inquiry |
DDX58-1048R | Recombinant Rhesus Macaque DDX58 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ddx58-2513M | Recombinant Mouse Ddx58 Protein, Myc/DDK-tagged | +Inquiry |
DDX58-2069H | Recombinant Human DDX58 Protein (Ile725-Lys925), N-His tagged | +Inquiry |
DDX58-10H | Recombinant Human DDX58, GST-tagged | +Inquiry |
◆ Lysates | ||
DDX58-7000HCL | Recombinant Human DDX58 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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