defa6

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defa6

Official Full Name defensin, alpha 6, Paneth cell-specific
Background Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel.
Synonyms DEFA6; defensin, alpha 6, Paneth cell-specific; defensin-6; DEF6; HD 6; alpha 6; DEF6_HUMAN; DEFA 6; Defensin 6; Defensin alpha 6; Defensin alpha 6 Paneth cell specific; Defensin; HD6; OTTHUMP00000115425; HD-6
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DEFA6-1140H Recombinant Human DEFA6 protein, His & GST-tagged E.coli His/GST
    Human DEFA6-2520H Recombinant Human DEFA6 Protein, GST-tagged Wheat Germ GST
    Human DEFA6-26996TH Recombinant Human DEFA6 Wheat Germ N/A
    Human DEFA6-451H Recombinant Human DEFA6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DEFA6-6990HCL Recombinant Human DEFA6 293 Cell Lysate HEK293 N/A
    Mouse Defa6-3356M Recombinant Mouse Defa6, His-tagged E.Coli or Yeast His
    Mouse DEFA6-4457M Recombinant Mouse DEFA6 Protein Mammalian Cell His

    defa6 involved in several pathways and played different roles in them. We selected most pathways defa6 participated on our site, such as Alpha-defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with defa6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alpha-defensins DEFA1; DEFA3; DEFA5; ART1; DEFA6
    Defensins DEFB4B; DEFB4A; DEFB104A; DEFB129; DEFB125; DEFB106A; DEFB1; DEFA6; DEFA1; DEFA3
    Immune System CR1; TRIM14; AP1S1; MYO9B; TREX1; TRIM17; CXADR; OSBPL1A; CD160; POLR3H
    Innate Immune System POLR3F; CRP; DEFB104A; POLR3H; CNPY3; ALCAMB; KIR2DS2; RNF135; CFHL1; DEFA6

    defa6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by defa6 itself. We selected most functions defa6 had, and list some proteins which have the same functions with defa6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FCHSD2; ANLN; EXOC8; DHX16; KPNA3; CNOT2; MT3; PMEPA1; HMBOX1; SYNPO2L

    defa6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with defa6 here. Most of them are supplied by our site. Hope this information will be useful for your research of defa6.

    UBQLN1; UBQLN1

    Xiao, L; Crabb, DM; et al. Suppression of Antimicrobial Peptide Expression by Ureaplasma Species. INFECTION AND IMMUNITY 82:1657-1665(2014).
    Lucero, CM; Junecko, BF; et al. Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts. CLINICAL AND VACCINE IMMUNOLOGY 20:1320-1328(2013).

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