DFFA
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Official Full Name
DNA fragmentation factor, 45kDa, alpha polypeptide
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Overview
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
DFFA; DNA fragmentation factor, 45kDa, alpha polypeptide; DFF1; ICAD; DFF-45; DNA fragmentation factor subunit alpha; DFF45; inhibitor of CAD; DNA fragmentation factor 45 kDa subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
DFFA involved in several pathways and played different roles in them. We selected most pathways DFFA participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DFFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of DNA fragmentation factor | HMGB2;HIST1H1E;HIST1H1C;HIST1H1B;HMGB2A;H1F0;HIST1H1D;HIST1H1A;DFFA |
| Apoptosis | PPP3CCA;BOK;BCL2;TRADD;BAXB;PPP3R1;PTBP3;CASP8;PRKACBA |
| Apoptosis Modulation and Signaling | CRADD;PTRH2;HN1;DAXX;BCL2L10;HRK;BIK;CASP2;PTPN13 |
| Apoptosis induced DNA fragmentation | DFFA;HIST1H1C;HIST1H1A;H1F0;HMGB2;HIST1H1E;HMGB2A;HIST1H1B;HIST1H1D |
| Apoptotic execution phase | OCLN;DNM1L;SATB1;STK24B;SPNA2;CTNNB2;DBNLB;DSG3;H1F0 |
| Caspase cascade in apoptosis | SATB1;CFL2;CASP4;PARP1;ACTA1;DIABLO;LMNB1;TOP1;TFAP2A |
| FAS pathway and Stress induction of HSP regulation | FAF1;LMNB2;DAXX;DFFA |
| HIV-1 Nef: Negative effector of Fas and TNF-alpha | CRADD;DAXX;DFFA;CASP2 |
DFFA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DFFA itself. We selected most functions DFFA had, and list some proteins which have the same functions with DFFA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCDC67;NR5A2;KLRG1;CHTOP;RBM10;FRS3;S100B;ENOX2;DKC1 |
DFFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DFFA here. Most of them are supplied by our site. Hope this information will be useful for your research of DFFA.
DFFB; YWHAG; YWHAZ; HSPB1; Dffb; 7460242
Research Area
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewWe felt well-supported throughout our usage of the product, thanks to the dedicated customer service.
Consistency in the product's behavior across experimental conditions enhanced the credibility of our findings.
The product's adaptability to various buffers contributed to its stable and reliable performance.
Q&As (7)
Ask a questionDysregulation or abnormal expression of DFFA is associated with various conditions, including cancer and neurodegenerative disorders, highlighting its role in apoptotic dysfunction.
DFFA contributes to DNA fragmentation and chromatin condensation by being cleaved and activated by caspases, particularly caspase-3, during apoptotic cell death.
DFFA is predominantly localized in the nucleus, specifically during the initiation of apoptosis, where it actively participates in chromatin condensation and DNA fragmentation.
There are potential therapeutic implications related to DFFA in diseases involving apoptotic dysregulation and abnormal cell survival, making it a target for drug development.
DNA Fragmentation Factor Subunit Alpha (DFFA) plays a crucial role in cellular processes, primarily contributing to the execution of apoptosis and programmed cell death.
DFFA actively participates in regulating the balance between cell survival and programmed cell death in various tissues, influencing tissue homeostasis.
Specific caspases, including caspase-3, activate DFFA, influencing its role in the execution phase of apoptosis and facilitating efficient DNA degradation.
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