DPP3

DPP3 is involved in the final stages of protein catabolism, breaking down small peptides into amino acids, which can then be reused in protein synthesis or participate in various metabolic pathways.

DPP3 expression varies among tissues, with higher levels in the heart, liver, and kidneys. Its expression is regulated by various factors, including hormonal and metabolic cues.

Some inhibitors targeting DPP3 have been identified, though their therapeutic implications are still under exploration. Inhibiting DPP3 might be beneficial in conditions where its overactivity contributes to disease pathology.

DPP3 is known to metabolize certain drugs, affecting their bioavailability and efficacy. Understanding DPP3's role in drug metabolism can help in drug design and dosage determination.

Dysregulation of DPP3 has been associated with certain cancers and inflammatory conditions. However, the exact pathological role of DPP3 in these conditions is still under investigation.

The DPP3 gene encodes dipeptidyl peptidase III (DPP3), an intracellular zinc-dependent enzyme. Its primary function is to cleave dipeptides from the N-termini of polypeptides.

Unlike other dipeptidyl peptidases, DPP3 has a broader substrate specificity, cleaving a variety of dipeptidyl-2-arylamide substrates and playing roles in multiple physiological processes.