dsg1

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dsg1

Official Full Name Desmoglein 1
Background Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
Synonyms DSG1; desmoglein 1; DGI; CDHF4; PPKS1; Cadherin family member 4; SPPK1; Desmosomal glycoprotein 1; DSG; Pemphigus foliaceus antigen; desmoglein-1; DG1; OTTHUMP00000162826; DSG2; desmoglein 2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037; Desmoglein-2
    • Species :
    • Human
    • Source :
    • E.coli
    • NS0
    • NSO
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DSG1-12178H Recombinant Human DSG1, His-tagged E.coli His
    Human DSG1-1601H Recombinant Human Desmoglein 1 NSO N/A
    Human DSG1-26581TH Recombinant Human DSG1 Wheat Germ N/A
    Human DSG1-2890H Recombinant Human DSG1 Protein, GST-tagged Wheat Germ GST
    Human DSG1-512HCL Recombinant Human DSG1 cell lysate N/A
    Human DSG1-820H Recombinant Human DSG1 protein, His & GST-tagged E.coli His/GST
    Human DSG1-8319H Recombinant Human DSG1 NS0 N/A

    dsg1 involved in several pathways and played different roles in them. We selected most pathways dsg1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with dsg1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis BAX; TRADD; PRKACB; BIRC5A; BIDA; RNF8; TNFSF10; PPP3R1B; CASP7; PIK3R5
    Apoptotic cleavage of cell adhesion proteins DSG2; DSG3; DSG1; DSP; OCLN; CTNNB1; PTBP3; PKP1; CTNNB2
    Apoptotic cleavage of cellular proteins CLSPN; DSG2; DBNL; BMX; STK26; PTBP3; CASP6L2; PKP1; CASP6L1; DBNLB
    Apoptotic execution phase HIST1H1A; VIML; STK24A; PTBP3; HIST1H1B; HIST1H1C; DSG1; BCAP31; CTNNB1; PLECA
    Programmed Cell Death DBNLB; STK24; ADD1; DBNL; BAXB; STK24B; RNF8; DIABLOA; DSG2; DSG3
    Staphylococcus aureus infection ICAM1; Itgam&Itgb2; ITGAM; FGG; FPR3; CFI; HLA-DRB1; ITGB2; MBL2; FPR1

    dsg1 has several biochemical functions, for example, calcium ion binding, gamma-catenin binding, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dsg1 itself. We selected most functions dsg1 had, and list some proteins which have the same functions with dsg1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PLCD3A; TLL1; EFHA1; PLCD1; S100A8; TPD52; ANXA3B; SCGN; JAG2; PCDH2AB12
    gamma-catenin binding LEF1; DSG1A; DSG1; PTPRK; FER; APC; PTPRJ; CDH1; APC2; TCF7L2
    toxic substance binding Alb; A4GALT; H2-AB1; NEFH; GUCY2C; CHRNA7; DSG1; ASS1; EPHX2; AZU1

    dsg1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsg1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dsg1.

    SSSCA1; USP1; GH1; OTUD4; USP53; VRK3; q9nz47_human; RUVBL1; midostaurin; cona_canen; ESR1; CFTR; IQGAP1; PLK1; CD81; GABARAPL2; PPP2R2B; MAPK7; IQCB1

    Aoki, V; Rivitti, EA; et al. Update on fogo selvagem, an endemic form of pemphigus foliaceus. JOURNAL OF DERMATOLOGY 42:18-26(2015).
    Kinjyo, C; Kaneko, T; et al. Oral lichen planus with antibodies to desmogleins 1 and 3. JOURNAL OF DERMATOLOGY 42:40-41(2015).

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