|Official Full Name||Desmoglein 1|
|Background||Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.|
|Synonyms||DSG1; desmoglein 1; DGI; CDHF4; PPKS1; Cadherin family member 4; SPPK1; Desmosomal glycoprotein 1; DSG; Pemphigus foliaceus antigen; desmoglein-1; DG1; OTTHUMP00000162826; DSG2; desmoglein 2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037; Desmoglein-2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
dsg1 involved in several pathways and played different roles in them. We selected most pathways dsg1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with dsg1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Apoptosis||BAX; TRADD; PRKACB; BIRC5A; BIDA; RNF8; TNFSF10; PPP3R1B; CASP7; PIK3R5|
|Apoptotic cleavage of cell adhesion proteins||DSG2; DSG3; DSG1; DSP; OCLN; CTNNB1; PTBP3; PKP1; CTNNB2|
|Apoptotic cleavage of cellular proteins||CLSPN; DSG2; DBNL; BMX; STK26; PTBP3; CASP6L2; PKP1; CASP6L1; DBNLB|
|Apoptotic execution phase||HIST1H1A; VIML; STK24A; PTBP3; HIST1H1B; HIST1H1C; DSG1; BCAP31; CTNNB1; PLECA|
|Programmed Cell Death||DBNLB; STK24; ADD1; DBNL; BAXB; STK24B; RNF8; DIABLOA; DSG2; DSG3|
|Staphylococcus aureus infection||ICAM1; Itgam&Itgb2; ITGAM; FGG; FPR3; CFI; HLA-DRB1; ITGB2; MBL2; FPR1|
dsg1 has several biochemical functions, for example, calcium ion binding, gamma-catenin binding, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dsg1 itself. We selected most functions dsg1 had, and list some proteins which have the same functions with dsg1. You can find most of the proteins on our site.
|calcium ion binding||PLCD3A; TLL1; EFHA1; PLCD1; S100A8; TPD52; ANXA3B; SCGN; JAG2; PCDH2AB12|
|gamma-catenin binding||LEF1; DSG1A; DSG1; PTPRK; FER; APC; PTPRJ; CDH1; APC2; TCF7L2|
|toxic substance binding||Alb; A4GALT; H2-AB1; NEFH; GUCY2C; CHRNA7; DSG1; ASS1; EPHX2; AZU1|
dsg1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsg1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dsg1.
SSSCA1; USP1; GH1; OTUD4; USP53; VRK3; q9nz47_human; RUVBL1; midostaurin; cona_canen; ESR1; CFTR; IQGAP1; PLK1; CD81; GABARAPL2; PPP2R2B; MAPK7; IQCB1