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Official Full Name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
Synonyms DUSP11; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); RNA/RNP complex-1-interacting phosphatase; PIR1; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1; RNA/RNP complex interacting phosphatase; RNA/RNP complex1 intereracting phosphatase; Serine/threonine specific protein phosphatase; RNA/RNP complex-interacting phosphatase
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP11-12204H Recombinant Human DUSP11, GST-tagged E.coli GST
    Human DUSP11-2923H Recombinant Human DUSP11 Protein, GST-tagged Wheat Germ GST
    Human DUSP11-640H Recombinant Human DUSP11 Protein, His-tagged E.coli His
    Human DUSP11-6783HCL Recombinant Human DUSP11 293 Cell Lysate HEK293 N/A
    Mouse DUSP11-4876M Recombinant Mouse DUSP11 Protein Mammalian Cell His
    Rat DUSP11-1972R Recombinant Rat DUSP11 Protein Mammalian Cell His
    Zebrafish DUSP11-2477Z Recombinant Zebrafish DUSP11 Mammalian Cell His

    dusp11 involved in several pathways and played different roles in them. We selected most pathways dusp11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dusp11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    dusp11 has several biochemical functions, for example, RNA binding, nucleotide phosphatase activity, acting on free nucleotides, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dusp11 itself. We selected most functions dusp11 had, and list some proteins which have the same functions with dusp11. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide phosphatase activity, acting on free nucleotides PGP; NUDT16; NTPCR; DUSP11
    phosphatase activity CDC14AA; SACM1LB; PTPN23A; PTPREB; ATP1A1; ACPP; SACM1L; PTPRUB; PPM1F; SACM1LA
    poly(A) RNA binding HNRNPH3; ZC3H18; RPL31; CS; WDR3; APEX1; FASN; PES1; DUSP11; WIBG
    polynucleotide 5-phosphatase activity RNGTT; DUSP11
    protein tyrosine phosphatase activity PTENB; MTMR1; MTMR14; DUSP26; PTPN11; DUSP14; PTEN; DUSP12; CDC25C; DUSP19
    protein tyrosine/serine/threonine phosphatase activity DUSP22B; DUSP19A; DUPD1; CDC14AA; SSH2B; PTENA; DUSP22A; PXYLP1; DUSP3; DUSP9

    dusp11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dusp11 here. Most of them are supplied by our site. Hope this information will be useful for your research of dusp11.

    QARS; HNRNPA1; KIF11; Csde1; THOC1

    Abers, HMHG; Kuijl, C; et al. Integrating Chemical and Genetic Silencing Strategies To Identify Host Kinase-Phosphatase Inhibitor Networks That Control Bacterial Infection. ACS CHEMICAL BIOLOGY 9:414-422(2014).
    Nallaparaju, KC; Zhang, YL; et al. DUSP11 is a critical regulator of innate immune responses mediated by dendritic cells. CYTOKINE 63:286-286(2013).

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