DUSP6

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DUSP6

Official Full Name dual specificity phosphatase 6
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms DUSP6; dual specificity phosphatase 6; dual specificity protein phosphatase 6; MKP 3; PYST1; MAP kinase phosphatase 3; dual specificity protein phosphatase PYST1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP6-12218H Recombinant Human DUSP6, GST-tagged E.coli GST
    Human DUSP6-2945H Recombinant Human DUSP6 Protein, GST-tagged Wheat Germ GST
    Human DUSP6-384H Recombinant Human DUSP6 Protein, His-tagged E.coli His
    Human DUSP6-5116H Recombinant Human DUSP6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DUSP6-631H Recombinant Human DUSP6 Sf9 Insect Cell N/A
    Human DUSP6-666H Recombinant Human DUSP6, GST-tagged E.coli GST
    Human DUSP6-6770HCL Recombinant Human DUSP6 293 Cell Lysate HEK293 N/A
    Mouse Dusp6-2691M Recombinant Mouse Dusp6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse DUSP6-4892M Recombinant Mouse DUSP6 Protein Mammalian Cell His
    Rat DUSP6-1978R Recombinant Rat DUSP6 Protein Mammalian Cell His
    Rhesus Macaque DUSP6-1356R Recombinant Rhesus monkey DUSP6 Protein, His-tagged Mammalian Cell His
    Chicken DUSP6-5925C Recombinant Chicken DUSP6 Mammalian Cell His
    Zebrafish DUSP6-9730Z Recombinant Zebrafish DUSP6 Mammalian Cell His

    DUSP6 involved in several pathways and played different roles in them. We selected most pathways DUSP6 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation SPTB; KIDINS220B; SPTBN2; CSF2; PEA15A; SPNA1; EGFR; FRS2A; LAMTOR2; PSMA8
    Activated TLR4 signalling RIPK3; PELI2; DUSP7; TLR6; DHX9; TIRAP; CHST13; DUSP3B; TANK; ATF2
    Axon guidance SEMA5B; EPHA8; AP2A2; ROBO1; RASA1; RHOAE; CSNK2B; EFNA5; EPHB6; SEMA4B
    B Cell Receptor Signaling Pathway RAF1; CSK; CRKL; PLEKHA1; VAV1; DUSP4; PDK2B; LYN; DOK3; LCP2A
    Cytokine Signaling in Immune system CRK; HAVCR2; WDR83; GBP5; SAMHD1; ADAR; IRAK3; SPRED3; PHB; CISH
    DAP12 interactions SIRPB1; MARK3; GRAP2B; AGO1; GRAP2A; FRS3; NRG3; PTPRA; CNKSR1; SIGLEC15
    DAP12 signaling NRG4; SPRED2; RASGRP1; SPNA1; CNKSR1; GRAP2A; IL17RD; SPTBN1; PTPRA; AGO1
    Developmental Biology LGI1A; NRG4; CDK5R1B; CLTC; SPTBN2; COL4A3; SPAG9; FGFR1B; COL9A1A; ARPC1A

    DUSP6 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP6 itself. We selected most functions DUSP6 had, and list some proteins which have the same functions with DUSP6. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity PXYLP1; DUSP9; DUSP8A; CTDSPL2A; SACM1LB; NT5DC3; DUSP21; DUSP5; DUSP10; PTPRQ
    protein tyrosine phosphatase activity PALD1A; MTMR6; PTPN23A; PTPRG; EYA4; PTPN6; PTPN13; DUSP22; MTMR7; MTMR1B

    DUSP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP6.

    SRPK1; MAPK3; MAPK1; TEX11; MDFI; ZNF212

    Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
    Dickinson, RJ; Delavaine, L; et al. Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways. JOURNAL OF BIOLOGICAL CHEMISTRY 286:38018-38026(2011).

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