DUSP6

  • Official Full Name

    dual specificity phosphatase 6

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    DUSP6; dual specificity phosphatase 6; dual specificity protein phosphatase 6; MKP 3; PYST1; MAP kinase phosphatase 3; dual specificity protein phosphatase PYST1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insects cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP6-666H Active Recombinant Human DUSP6, GST-tagged E.coli GST
Human DUSP6-631H Active Recombinant Human DUSP6 Protein Insects cell
Human DUSP6-12218H Recombinant Human DUSP6, GST-tagged E.coli GST 1-218a.a.
Human DUSP6-2945H Recombinant Human DUSP6 Protein, GST-tagged Wheat Germ GST
Human DUSP6-6770HCL Recombinant Human DUSP6 293 Cell Lysate HEK293 N/A
Human DUSP6-384H Recombinant Human DUSP6 Protein, His-tagged E.coli His Met1~Ser300
Human DUSP6-5116H Recombinant Human DUSP6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DUSP6-2009H Recombinant Human DUSP6 Protein (Met1-Leu347), N-His tagged E.coli N-His Met1-Leu347
Human DUSP6-385H Recombinant Human DUSP6 protein, His-Myc-tagged E.coli His/Myc 1-381aa
Human DUSP6-3133H Recombinant Human DUSP6 protein, His-tagged E.coli His 73-133 aa
Human DUSP6-4119HF Recombinant Full Length Human DUSP6 Protein, GST-tagged In Vitro Cell Free System GST 381 amino acids
Mouse DUSP6-4892M Recombinant Mouse DUSP6 Protein Mammalian Cell His
Mouse Dusp6-2691M Recombinant Mouse Dusp6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DUSP6-2573M Recombinant Mouse DUSP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DUSP6-2573M-B Recombinant Mouse DUSP6 Protein Pre-coupled Magnetic Beads HEK293
Rat DUSP6-1978R Recombinant Rat DUSP6 Protein Mammalian Cell His
Rat DUSP6-1637R-B Recombinant Rat DUSP6 Protein Pre-coupled Magnetic Beads HEK293
Rat DUSP6-1637R Recombinant Rat DUSP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DUSP6-1356R Recombinant Rhesus monkey DUSP6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DUSP6-1181R-B Recombinant Rhesus Macaque DUSP6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DUSP6-1181R Recombinant Rhesus Macaque DUSP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DUSP6-9730Z Recombinant Zebrafish DUSP6 Mammalian Cell His
Chicken DUSP6-5925C Recombinant Chicken DUSP6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DUSP6 involved in several pathways and played different roles in them. We selected most pathways DUSP6 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationRASGRP1;SPTA1;PEBP1;PSMD5;RASGRP4;FGF10B;CRK;CSF2RB;DUSP1
Activated TLR4 signallingCREB1B;PELI3;DUSP7;SAA1;DUSP6;TLR6;AGER;TIRAP;DUSP4
Axon guidanceITSN1;ARPC3;PAQR3A;RASGEF1A;LAMTOR2;EPHA3;ABLIM3;SEMA4B;ROBO2
B Cell Receptor Signaling PathwayCMTM3;PIK3R3;FOS;CR2;BLK;ACTR2;LYN;PLEKHA2;RAC3
Cytokine Signaling in Immune systemUBE2V1;NRG3;MAP3K8;RASGRP1;TRIM22;SPRED3;FRS3;FCGR1B;FRS2
DAP12 interactionsRASGRP1;CD300LB;DAB2IPB;SPTBN2;DUSP9;JAK3;LCP2A;KBTBD7;DUSP2
DAP12 signalingSPRED2;HBEGF;RASGRP4;AGO2;FRS2B;PHB;JAK1;IL17RD;FGF18B
Developmental BiologyTCF4;ITGB1B.1;LGI4;SCN4A;SEMA4D;MED16;PAQR3B;MED20;UNC5D

DUSP6 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP6 itself. We selected most functions DUSP6 had, and list some proteins which have the same functions with DUSP6. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activitySACM1LB;DUSP6;SGPP2;DUSP16;DUSP9;SACM1LA;DUSP8A;PTPRQ;DUSP10
protein tyrosine phosphatase activityPTPRC;PTPN4B;CDC14A;TIMM50;PTPN11B;MDP1;DUSP28;CDC14B;DUSP10

DUSP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP6.

SRPK1; MAPK3; MAPK1; TEX11; MDFI; ZNF212

Research Area

Related articles

Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
Dickinson, RJ; Delavaine, L; et al. Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways. JOURNAL OF BIOLOGICAL CHEMISTRY 286:38018-38026(2011).
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