ARHGEF15
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 15
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Overview
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. -
Synonyms
ARHGEF15; Rho guanine nucleotide exchange factor (GEF) 15; rho guanine nucleotide exchange factor 15; ARGEF15; FLJ13791; KIAA0915; MGC44868; Rho guanine exchange factor (GEF) 15; Vsm RhoGEF; ephexin-5; Rho GEF 15; E5; Ephexin5; Vsm-RhoGEF;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARHGEF15-889H | Recombinant Human ARHGEF15 | Mammalian Cell | His | ||
Human | ARHGEF15-8733HCL | Recombinant Human ARHGEF15 293 Cell Lysate | HEK293 | N/A | ||
Human | ARHGEF15-2496H-B | Recombinant Human ARHGEF15 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | ARHGEF15-2496H | Recombinant Human ARHGEF15 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Arhgef15-1692M | Recombinant Mouse Arhgef15 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF15 involved in several pathways and played different roles in them. We selected most pathways ARHGEF15 participated on our site, such as EPHA forward signaling, Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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EPHA forward signaling | EFNA2;CRKL;BLK;EPHA2;EFNA5;EFNA3;EFNA1;ARHGEF15 |
Regulation of RhoA activity | FARP1;AKAP13;ARHGEF10;DEF6;ARAP1;ARHGEF18;PLEKHG6;ABR;DLC1 |
ARHGEF15 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF15 itself. We selected most functions ARHGEF15 had, and list some proteins which have the same functions with ARHGEF15. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | SRGAP2B;RGS2;TBC1D7;FAM13B1;OPHN1;TSC2;TBC1D26;RASAL2;TBC1D10A |
Rho guanyl-nucleotide exchange factor activity | ARHGEF7B;ARHGEF10;FGD5;PLEKHG5;ECT2;MCF2L;QUO;SOS1;ARHGEF10L |
protein binding | SEPT7;PARL;GGA3;BLOC1S1;XAGE2;CLK2;CXCR5;GMDS;ANKRD24 |
ARHGEF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF15.
C11orf49; MOB4
- Q&As
- Reviews
Q&As (16)
Ask a questionCurrently, there are no specific drugs or compounds that directly target ARHGEF15. However, there are drugs that target Rho GTPases or related signaling pathways, which can indirectly affect ARHGEF15 activity. These drugs could potentially be explored for their effects on ARHGEF15-mediated signaling.
The current research on ARHGEF15 is relatively limited, and further investigations are needed to fully understand its function and significance. However, ongoing studies may focus on elucidating its precise role in Rho GTPase regulation, identifying its binding partners and associated signaling pathways, exploring its involvement in human diseases, and investigating potential therapeutic targets for ARHGEF15-mediated processes.
At present, there is limited information on animal models specifically targeting ARHGEF15. However, there may be generalized knockout or overexpression models of Rho GTPases or related signaling pathway components that indirectly affect ARHGEF15. These models could provide insights into the potential role of ARHGEF15 in various physiological and pathological processes. Development of specific animal models targeting ARHGEF15 could be a valuable tool for studying its function and exploring its potential therapeutic implications.
ARHGEF15 expression shows some variation among cell types. While it is expressed in multiple tissues, the level of expression can differ within different types of cells or tissues. Factors such as developmental stage, cellular environment, and specific physiological conditions may influence the expression pattern of ARHGEF15 in different cell types.
The specific protein interactions of ARHGEF15 are not extensively characterized. However, being a guanine nucleotide exchange factor (GEF), it is expected to interact with Rho GTPases and potentially other proteins involved in the regulation of the cytoskeleton. Further research is required to identify and characterize the binding partners of ARHGEF15.
Although information is limited, some studies suggest that ARHGEF15 expression can be regulated by various factors. For example, it has been reported that certain microRNAs (miRNAs) can interact with the mRNA of ARHGEF15 and regulate its expression levels. Additionally, other signaling pathways or transcription factors may also play a role in regulating the expression of ARHGEF15.
There is limited information available regarding genetic variations or mutations specifically associated with ARHGEF15. However, genetic studies and sequencing projects may have identified single nucleotide polymorphisms (SNPs) or other genetic variations within the ARHGEF15 gene. Further investigation is necessary to determine if any of these variations have functional implications or are associated with specific phenotypes or diseases.
While the primary known function of ARHGEF15 is its involvement in the regulation of Rho GTPases, it is possible that it may have additional roles in other cellular processes. Since Rho GTPases are key regulators of various cellular functions, it is conceivable that ARHGEF15 might indirectly influence processes such as cell cycle progression, cytoskeletal dynamics, or intracellular signaling pathways. However, further research is required to explore these potential functions.
Currently, there is limited information on specific diseases or disorders directly associated with ARHGEF15. However, dysregulation of Rho GTPase signaling, which ARHGEF15 is involved in, has been implicated in various pathological conditions. For example, aberrant Rho GTPase activity has been linked to cancer, neurodegenerative disorders, cardiovascular diseases, and immune disorders. Further studies are needed to determine if ARHGEF15 dysregulation contributes to the development or progression of any specific diseases.
ARHGEF15's involvement in specific cellular pathways is not well understood. However, as a guanine nucleotide exchange factor for Rho GTPases, ARHGEF15 is likely involved in signaling pathways related to cytoskeletal dynamics, cell adhesion, and migration. Rho GTPases are known to interact with multiple signaling cascades, such as the MAPK/ERK pathway, the PI3K/Akt pathway, and the Wnt signaling pathway. Further research is needed to determine the precise cellular pathways in which ARHGEF15 participates.
Are there any known drugs or therapeutic approaches targeting ARHGEF15?
Currently, there is limited information available about post-translational modifications (PTMs) of ARHGEF15. PTMs can include phosphorylation, acetylation, ubiquitination, or glycosylation, among others, and can regulate protein function and interactions. Further research is needed to investigate if ARHGEF15 undergoes any specific PTMs and how these modifications might influence its activity or cellular localization.
There is limited information regarding the involvement of ARHGEF15 in human diseases. However, some studies have suggested possible associations between ARHGEF15 and certain conditions such as cancer. Further research is needed to fully understand the potential roles of ARHGEF15 in disease progression and its clinical significance.
ARHGEF15 is expressed in a variety of tissues but its expression levels can vary depending on the tissue type and developmental stage. It has been detected in various organs including the brain, heart, liver, and skeletal muscle, among others.
There is limited research on the specific role of ARHGEF15 in cancer. However, dysregulation of Rho GTPase signaling, in which ARHGEF15 is involved, has been implicated in cancer progression and metastasis. Rho GTPases play a vital role in regulating the cytoskeleton, cell migration, and invasion, all of which are critical processes in cancer development and metastasis. Further studies are needed to determine the extent of ARHGEF15's involvement in cancer and its potential as a therapeutic target.
The specific binding partners or interactors of ARHGEF15 have not been extensively characterized. However, as ARHGEF15 is involved in Rho GTPase regulation, it is likely to interact with various Rho GTPases and other proteins within the signaling pathway. Identifying the precise binding partners of ARHGEF15 and understanding their functional implications is an important area of ongoing research.
Customer Reviews (8)
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