EDNRB
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Official Full Name
endothelin receptor type B
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Overview
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] -
Synonyms
EDNRB; endothelin receptor type B; ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; endothelin B receptor; endothelin receptor non-selective type;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
- Equus caballus (Horse)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- Fc
- GST
- His
- Avi
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | EDNRB-272H | Recombinant Human EDNRB, Fc-tagged | Human Cell | Fc | Met1-Lys101 |
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| Human | EDNRB-687H | Recombinant Human EDNRB protein(Met1-Lys101), His-tagged | HEK293 | His | Met1-Lys101 |
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| Human | EDNRB-12286H | Recombinant Human EDNRB, His-tagged | E.coli | His | 27-99a.a. | |
| Human | EDNRB-3061H | Recombinant Human EDNRB Protein, GST-tagged | Wheat Germ | GST |
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| Human | EDNRB-28559TH | Recombinant Human EDNRB | Wheat Germ | Non | 75 amino acids |
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| Human | EDNRB-001HCL | Recombinant Human EDNRB cell lysate | Human Cell | Non |
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| Human | EDNRB-1209H | Recombinant Human EDNRB Protein, MYC/DDK-tagged | HEK293 | Myc&DDK |
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| Human | EDNRB-1376H | Recombinant Human EDNRB Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc&DDK |
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| Human | EDNRB-284H | Active Recombinant Fluorescent Human EDNRB Full Length Transmembrane protein(VLPs) | HEK293 | Non | Glu 27 - Ser 442 |
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| Human | EDNRB-4203HF | Recombinant Full Length Human EDNRB Protein, GST-tagged | In Vitro Cell Free System | GST | 442 amino acids |
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| Human | EDNRB-9103H | Active Recombinant Human EDNRB Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 27-442aa |
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| Mouse | EDNRB-4995M | Recombinant Mouse EDNRB Protein | Mammalian Cell | His |
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| Mouse | EDNRB-2642M | Recombinant Mouse EDNRB Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | Ednrb-2730M | Recombinant Mouse Ednrb Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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| Mouse | EDNRB-2642M-B | Recombinant Mouse EDNRB Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | EDNRB-2012R | Recombinant Rat EDNRB Protein | Mammalian Cell | His |
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| Rat | EDNRB-1669R | Recombinant Rat EDNRB Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | EDNRB-1669R-B | Recombinant Rat EDNRB Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bos taurus (Bovine) | RFL23628BF | Recombinant Full Length Bovine Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-441) |
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| Canis lupus familiaris (Dog) (Canis familiaris) | RFL6232CF | Recombinant Full Length Dog Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-442) |
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| Coturnix japonica (Japanese quail) (Coturnix coturnix japonica) | RFL21402CF | Recombinant Full Length Coturnix Coturnix Japonica Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-347) |
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| Equus caballus (Horse) | RFL985EF | Recombinant Full Length Horse Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-443) |
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| Homo sapiens (Human) | RFL14596HF | Recombinant Full Length Human Endothelin B Receptor(Ednrb) (Active) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-442aa) |
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| Mus musculus (Mouse) | RFL10102MF | Recombinant Full Length Mouse Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-442) |
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| Oryctolagus cuniculus (Rabbit) | RFL26513OF | Recombinant Full Length Rabbit Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-441) |
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| Rattus norvegicus (Rat) | RFL19386RF | Recombinant Full Length Rat Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-442) |
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| Sus scrofa (Pig) | RFL22181SF | Recombinant Full Length Pig Endothelin B Receptor(Ednrb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-443) |
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| Chicken | EDNRB-1068C | Recombinant Chicken EDNRB | Mammalian Cell | His |
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| Kit-0982 | Thrombin Generation Assay Kit | Non |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
EDNRB involved in several pathways and played different roles in them. We selected most pathways EDNRB participated on our site, such as Arf6 trafficking events, Calcium signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arf6 trafficking events | CHRM2;DNM2;CLTC;EDNRB;SCAMP2;EXOC3;EXOC6;EXOC1;CTNND1 |
| Calcium signaling pathway | CALM2A;GRPR;SLC8A1;CHRM5;TACR3L;EDNRAA;CYSLTR2;TRHR2;CAMK2D |
| Class A/1 (Rhodopsin-like receptors) | LPAR2B;ADRA2C;ANXA1;ADRB3;TAC3;HRH3;DRD1;TRH;DRD4 |
| Endothelin | EDNRB;CALCRL;CNN1;CALCA;EDNRA;EDN1;RAMP1;MYL1;ECE1 |
| Endothelins | EDN2;EDNRB;EDN3;EDNRA;COL1A2;EDN1;COL3A1;CYSLTR1 |
| G alpha (q) signalling events | LPAR2A;TRPC6A;TRPC3;GCGB;UTS2;NMBA;OPN4B;EDNRA;OPN4 |
| GPCR downstream signaling | TRH;OPN1LW1;GPR18;PMCH;ADORA3;EDNRAB;TRPC3;KISS1;PYY |
| GPCR ligand binding | PPY;CCL35.1;GPR55;LPAR2B;RGR;RHOL;ADORA3;PRLH;GPRC6A |
EDNRB has several biochemical functions, for example, endothelin receptor activity, peptide hormone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRB itself. We selected most functions EDNRB had, and list some proteins which have the same functions with EDNRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endothelin receptor activity | EDNRAA;EDNRA;EDNRB;EDNRBA;EDNRAB |
| peptide hormone binding | ACVR1;HCRTR1;GALR1;INHBA;RXFP2;EDNRB;MC4R;OXTR;CRHR2 |
| protein binding | ANO6;DROSHA;ZKSCAN3;RPS26;RFESD;STIM1;ELMO3;SNRPD3;TCEB1 |
EDNRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRB here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRB.
EDN1
Gene Family
Research Area
Related articles
Wang, C; Wang, HY; et al. Genome-wide analysis reveals artificial selection on coat colour and reproductive traits in Chinese domestic pigs. MOLECULAR ECOLOGY RESOURCES 15:414-424(2015).
Moore, SW; Zaahl, M; et al. Clinical and genetic correlations of familial Hirschsprung's disease. JOURNAL OF PEDIATRIC SURGERY 50:285-288(2015).
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