EDNRB

  • Official Full Name

    endothelin receptor type B

  • Overview

    The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
  • Synonyms

    EDNRB; endothelin receptor type B; ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; endothelin B receptor; endothelin receptor non-selective type;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
  • Equus caballus (Horse)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EDNRB-272H Recombinant Human EDNRB, Fc-tagged Human Cell Fc Met1-Lys101
Human EDNRB-687H Recombinant Human EDNRB protein(Met1-Lys101), His-tagged HEK293 C-His Met1-Lys101
Human EDNRB-12286H Recombinant Human EDNRB, His-tagged E.coli His 27-99a.a.
Human EDNRB-3061H Recombinant Human EDNRB Protein, GST-tagged Wheat Germ GST
Human EDNRB-28559TH Recombinant Human EDNRB Wheat Germ N/A 75 amino acids
Human EDNRB-001HCL Recombinant Human EDNRB cell lysate Human Cell N/A
Human EDNRB-1209H Recombinant Human EDNRB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EDNRB-1376H Recombinant Human EDNRB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EDNRB-284H Active Recombinant Fluorescent Human EDNRB Full Length Transmembrane protein(VLPs) HEK293 N/A Glu 27 - Ser 442
Human EDNRB-4203HF Recombinant Full Length Human EDNRB Protein, GST-tagged In Vitro Cell Free System GST 442 amino acids
Human EDNRB-9103H Active Recombinant Human EDNRB Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 27-442aa
Mouse EDNRB-4995M Recombinant Mouse EDNRB Protein Mammalian Cell His
Mouse EDNRB-2642M Recombinant Mouse EDNRB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ednrb-2730M Recombinant Mouse Ednrb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse EDNRB-2642M-B Recombinant Mouse EDNRB Protein Pre-coupled Magnetic Beads HEK293
Rat EDNRB-2012R Recombinant Rat EDNRB Protein Mammalian Cell His
Rat EDNRB-1669R Recombinant Rat EDNRB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EDNRB-1669R-B Recombinant Rat EDNRB Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL23628BF Recombinant Full Length Bovine Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-441)
Canis lupus familiaris (Dog) (Canis familiaris) RFL6232CF Recombinant Full Length Dog Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-442)
Coturnix japonica (Japanese quail) (Coturnix coturnix japonica) RFL21402CF Recombinant Full Length Coturnix Coturnix Japonica Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length (1-347)
Equus caballus (Horse) RFL985EF Recombinant Full Length Horse Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-443)
Homo sapiens (Human) RFL14596HF Recombinant Full Length Human Endothelin B Receptor(Ednrb) (Active) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-442aa)
Mus musculus (Mouse) RFL10102MF Recombinant Full Length Mouse Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-442)
Oryctolagus cuniculus (Rabbit) RFL26513OF Recombinant Full Length Rabbit Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-441)
Rattus norvegicus (Rat) RFL19386RF Recombinant Full Length Rat Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-442)
Sus scrofa (Pig) RFL22181SF Recombinant Full Length Pig Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-443)
Chicken EDNRB-1068C Recombinant Chicken EDNRB Mammalian Cell His
Kit-0982 Thrombin Generation Assay Kit N/A
Kit-1230 EDNRB CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1231 EDNRB Total GPCR Internalization Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

EDNRB involved in several pathways and played different roles in them. We selected most pathways EDNRB participated on our site, such as Arf6 trafficking events, Calcium signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arf6 trafficking eventsEXOC1;PTBP3;CLTC;JUP;SPAG9;ADRB2;SCAMP2;EXOC3;EDNRB
Calcium signaling pathwayPHKA2;P2RX3B;ATP2B2;Adcy4;PLCD1B;ADRB3;ATP2A3;ADRB3B;AGTR1B
Class A/1 (Rhodopsin-like receptors)OPN4B;NPSR1;OPN1SW1;CYSLTR1;RHOL;CCK;OPN1MW;TAC1;EDN3
EndothelinMYL1;CALCA;EDNRA;EDNRB;CNN1;RAMP1;ECE1;EDN1;CALCRL
EndothelinsCOL3A1;EDNRA;EDN2;EDN3;EDN1;EDNRB;COL1A2;CYSLTR1
G alpha (q) signalling eventsFFAR3;GPR132B;CYSLTR1;RGS21;PROK1;PROKR1;TRPC6A;UTS2D;GPR17
GPCR downstream signalingARHGAP4;FPR-RS6;NMS;CCR8;QRFPR;CCL19A.2;RGS12;ADRB3;CHRM4
GPCR ligand bindingGPR132;INSL5;EDNRB;PROKR2;SSTR4;LPAR2B;GPR18;GPR37L1;RAMP1

EDNRB has several biochemical functions, for example, endothelin receptor activity, peptide hormone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRB itself. We selected most functions EDNRB had, and list some proteins which have the same functions with EDNRB. You can find most of the proteins on our site.

Function Related Protein
endothelin receptor activityEDNRAA;EDNRAB;EDNRA;EDNRBA;EDNRB
peptide hormone bindingOXTR;GALR2;GHSR;GIPR;ANXA5;NPR3;GHRHR;EDNRB;MC4R
protein bindingDIAP1;PDGFRA;HMGB3;ZBTB48;FAAH;ADAMTS4;CRMP1;ATF5;SRPK3

EDNRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRB here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRB.

EDN1

Gene Family

GPCRs

Research Area

Related articles

Wang, C; Wang, HY; et al. Genome-wide analysis reveals artificial selection on coat colour and reproductive traits in Chinese domestic pigs. MOLECULAR ECOLOGY RESOURCES 15:414-424(2015).
Moore, SW; Zaahl, M; et al. Clinical and genetic correlations of familial Hirschsprung's disease. JOURNAL OF PEDIATRIC SURGERY 50:285-288(2015).
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