EIF2AK2

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EIF2AK2

Official Full Name eukaryotic translation initiation factor 2-alpha kinase 2
Background The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2AK2-12350H Recombinant Human EIF2AK2, His-tagged E.coli His
    Human EIF2AK2-1385H Recombinant Human EIF2AK2 Protein (2-551 aa), His-tagged Yeast His
    Human EIF2AK2-2983H Recombinant Human EIF2AK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF2AK2-298H Recombinant Human EIF2AK2, GST-tagged, Active Sf9 Insect Cell GST
    Human EIF2AK2-31020TH Recombinant Human EIF2AK2 N/A
    Human EIF2AK2-3148H Recombinant Human EIF2AK2 Protein, GST-tagged Insect Cell GST
    Human EIF2AK2-3149H Recombinant Human EIF2AK2 Protein, GST-tagged Wheat Germ GST
    Human EIF2AK2-332H Recombinant Human EIF2AK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2AK2-473H Recombinant Human EIF2AK2 Protein (2-551 aa), His-SUMO-tagged E.coli His/SUMO
    Human EIF2AK2-563H Recombinant Human EIF2AK2 protein, His-tagged E.coli His
    Human EIF2AK2-6674HCL Recombinant Human EIF2AK2 293 Cell Lysate HEK293 N/A
    Mouse Eif2ak2-2727M Recombinant Mouse Eif2ak2 protein, His & T7-tagged E.coli His/T7
    Mouse Eif2ak2-2771M Recombinant Mouse Eif2ak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse EIF2AK2-489M Recombinant Mouse Eif2ak2 protein, GST-tagged Insect Cell GST
    Mouse EIF2AK2-5076M Recombinant Mouse EIF2AK2 Protein Mammalian Cell His
    Rat EIF2AK2-2044R Recombinant Rat EIF2AK2 Protein Mammalian Cell His
    Rat Eif2ak2-2728R Recombinant Rat Eif2ak2 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque EIF2AK2-1414R Recombinant Rhesus monkey EIF2AK2 Protein, His-tagged Mammalian Cell His
    Chicken EIF2AK2-6057C Recombinant Chicken EIF2AK2 Mammalian Cell His
    Zebrafish EIF2AK2-6421Z Recombinant Zebrafish EIF2AK2 Mammalian Cell His

    EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum CALR3B; BAG2; EIF2AK2; CAPN2B; PRKCSH; UBXN6; CAPN2; UBE2J2; LMAN1L; ATF4
    Hepatitis C IFNA1; OSTN; OAS1B; MAVS; IRF9; PIAS1; TRAF6; EIF2AK4; RXRA; MAPK13
    Measles IFNA6; TBK1; HSPA2; HSPA6; TRAF6; FAS; IFIH1; IFNA1; Ifna15; IFNA16
    Influenza A OAS1; TMPRSS13; BMA2; PML; MAP2K1; HSPA2; PRKCA; HSPA1A; IFNA7; IFNA21
    Herpes simplex infection MHC2DCB; BLB2; TRAF5; IFNA21; IFNA5; NFKBIAA; TAF5; PKZ; IFNAR1; TBP
    Epstein-Barr virus infection MAP2K3; EIF2AK3; HLA-DQA1; MAPK10; POLR2A; PSMC5; PSMC2; IFNG; PIK3R1; HLA-B
    Viral carcinogenesis TRAF1; MRPS18B; REL; YWHAG; YWHAH; HDAC1; HIST1H2BK; BAD; GTF2H3; HIST1H4M

    EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MYHZ1.2; RET; HLTF; LATS2; PEX6; MOV10B.2; TRPM4; H1FNT; ITPKA; TIE1
    double-stranded RNA binding SLC3A2; YRDC; DHX15; IFIH1; ELAVL1; STAU1; MBNL1; AGO3; APTX; TARBP2
    eukaryotic translation initiation factor 2alpha kinase activity ALPK2; EIF2AK3; EIF2AK4; EIF2AK2; EIF2AK1
    non-membrane spanning protein tyrosine kinase activity TNK2B; CLK1; ABL2; TEC; LYN; MELK; HCK; SYK; BMX; YRK
    poly(A) RNA binding ERH; SNRPA1; FAM32A; SECISBP2; CHST13; RPS23; UBE2N; FASTKD5; MRPL41; DUSP11
    protein binding ASNS; MX2; PLD3; WHSC1; TOE1; HIST1H2BB; RBL1; EIF2A; MAP2; SPTSSA
    protein kinase activity MAP3K5; CSNK1G3; RNASEL; PDGFRA; JAK2B; KITB; PRKACAA; GC3; MAPK8B; NEK2
    protein phosphatase type 2A regulator activity PPP2R5CB; ENSA; PPP2R3A; PPP2R5B; PPP2R2D; PPP2R2A; EIF2AK2; ENSAA; PPP2R1B; PPP2R5EB
    protein serine/threonine kinase activity CDK16; CSNK1E; SRPK3; SIK3; PRKCBB; ARAF; PRKCQ; OXSR1B; BMP2K; RAF1A

    EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2.

    EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11

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