| Official Full Name | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Background | The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Synonyms | EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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EIF2AK2 involved in several pathways and played different roles in them. We selected most pathways EIF2AK2 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CALR3B; BAG2; EIF2AK2; CAPN2B; PRKCSH; UBXN6; CAPN2; UBE2J2; LMAN1L; ATF4 |
| Hepatitis C | IFNA1; OSTN; OAS1B; MAVS; IRF9; PIAS1; TRAF6; EIF2AK4; RXRA; MAPK13 |
| Measles | IFNA6; TBK1; HSPA2; HSPA6; TRAF6; FAS; IFIH1; IFNA1; Ifna15; IFNA16 |
| Influenza A | OAS1; TMPRSS13; BMA2; PML; MAP2K1; HSPA2; PRKCA; HSPA1A; IFNA7; IFNA21 |
| Herpes simplex infection | MHC2DCB; BLB2; TRAF5; IFNA21; IFNA5; NFKBIAA; TAF5; PKZ; IFNAR1; TBP |
| Epstein-Barr virus infection | MAP2K3; EIF2AK3; HLA-DQA1; MAPK10; POLR2A; PSMC5; PSMC2; IFNG; PIK3R1; HLA-B |
| Viral carcinogenesis | TRAF1; MRPS18B; REL; YWHAG; YWHAH; HDAC1; HIST1H2BK; BAD; GTF2H3; HIST1H4M |
EIF2AK2 has several biochemical functions, for example, ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK2 itself. We selected most functions EIF2AK2 had, and list some proteins which have the same functions with EIF2AK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MYHZ1.2; RET; HLTF; LATS2; PEX6; MOV10B.2; TRPM4; H1FNT; ITPKA; TIE1 |
| double-stranded RNA binding | SLC3A2; YRDC; DHX15; IFIH1; ELAVL1; STAU1; MBNL1; AGO3; APTX; TARBP2 |
| eukaryotic translation initiation factor 2alpha kinase activity | ALPK2; EIF2AK3; EIF2AK4; EIF2AK2; EIF2AK1 |
| non-membrane spanning protein tyrosine kinase activity | TNK2B; CLK1; ABL2; TEC; LYN; MELK; HCK; SYK; BMX; YRK |
| poly(A) RNA binding | ERH; SNRPA1; FAM32A; SECISBP2; CHST13; RPS23; UBE2N; FASTKD5; MRPL41; DUSP11 |
| protein binding | ASNS; MX2; PLD3; WHSC1; TOE1; HIST1H2BB; RBL1; EIF2A; MAP2; SPTSSA |
| protein kinase activity | MAP3K5; CSNK1G3; RNASEL; PDGFRA; JAK2B; KITB; PRKACAA; GC3; MAPK8B; NEK2 |
| protein phosphatase type 2A regulator activity | PPP2R5CB; ENSA; PPP2R3A; PPP2R5B; PPP2R2D; PPP2R2A; EIF2AK2; ENSAA; PPP2R1B; PPP2R5EB |
| protein serine/threonine kinase activity | CDK16; CSNK1E; SRPK3; SIK3; PRKCBB; ARAF; PRKCQ; OXSR1B; BMP2K; RAF1A |
EIF2AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK2.
EIF2S1; p27958-pro_0000037576; p27958-pro_0000037570; N/A; DHX30; US11
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