Recombinant Mouse Eif2ak2 protein, His & T7-tagged

• Cat.No.: Eif2ak2-2727M
• Product Overview: Recombinant Mouse Eif2ak2 aa. (Asn205~Glu495 (Accession # Q03963)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 37.2kDa
• Protein length: Asn205~Glu495 (Accession # Q03963)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 7.8.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Mus musculus (house mouse) ]
• Official Symbol: Eif2ak2
• Synonyms: Pkr; Tik; Prkr; AI467567; AI747578; 2310047A08Rik; 4732414G15Rik; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; P1/eIF-2A protein kinase; T-cell viral integration site; dsRNA-activated kinase; eIF-2 alpha; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; p68 kinase; protein kinase R; protein kinase RNA-activated; protein kinase, interferon-inducible double stranded RNA dependent; serine/threonine-protein kinase TIK; tyrosine-protein kinase EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase
• Gene ID: 19106
• mRNA Refseq: NM_011163.4
• Protein Refseq: NP_035293.1
• UniProt ID: Q03963

Reviews

03/05/2022

EIF2AK2 has a low immunogenicity and does not cause an abnormal immune response.

01/02/2022

Remarkable progress has been made in the application of EIF2AK2 in related fields.

06/14/2021

The activity of EIF2AK2 is similar to that of natural proteins and is able to perform its intended biological function.

Q&As

How does EIF2AK2 relate to apoptosis?

EIF2AK2 can be involved in the regulation of apoptosis by triggering the apoptotic process by inducing eIF2α phosphorylation.

Are there other coding variants in the EIF2AK gene?

Yes, in addition to the primary EIF2AK gene, there are other coding variants that may have different functions and expression patterns.

How is EIF2AK2 related to the development of tumors?

Studies have shown that EIF2AK2 abnormal expression levels in some tumors may be related to the occurrence and progression of tumors.

What are the possible causes of abnormal EIF2AK2 expression levels?

Abnormal EIF2AK2 expression levels may be due to genetic mutations, chromosomal abnormalities, environmental factors, etc.

How does EIF2AK2 have to do with viral infection?

Studies have shown that EIF2AK2 can participate in the regulation of antiviral immune responses and affect the course of viral infections.

What are the applications of EIF2AK2 in drug discovery?

EIF2AK2 can be used as a target for the development of new drugs, especially in the areas of neurodegenerative diseases and autoimmune diseases.