Human EIF2AK2 Knockdown Cell Lysate

• Cat.No.: EIF2AK2-152HKCL
• Product Overview: WB-validated EIF2AK2 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 62 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg EIF2AK2 KD HeLa cell lysate
• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Homo sapiens (human) ]
• Official Symbol: EIF2AK2
• Synonyms: EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PRKR, protein kinase, interferon inducible double stranded RNA dependent; interferon-induced, double-stranded RNA-activated protein kinase; EIF2AK1; PKR; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent; PRKR; MGC126524
• Gene ID: 5610
• mRNA Refseq: NM_001135651
• Protein Refseq: NP_001129123
• MIM: 176871
• UniProt ID: P19525