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Official Full Name eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Background The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; EIF-2B; EIF2Bgamma; translation initiation factor eIF-2B subunit gamma; eIF-2B GDP-GTP exchange factor subunit gamma;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2B3-12355H Recombinant Human EIF2B3, GST-tagged E.coli GST
    Human EIF2B3-28491TH Recombinant Human EIF2B3, His-tagged E.coli His
    Human EIF2B3-3157H Recombinant Human EIF2B3 Protein, GST-tagged Wheat Germ GST
    Human EIF2B3-327H Recombinant Human EIF2B3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2B3-333H Recombinant Human EIF2B3 Protein, His-tagged E.coli His
    Human EIF2B3-4557H Recombinant Human EIF2B3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF2B3-6671HCL Recombinant Human EIF2B3 293 Cell Lysate HEK293 N/A
    Mouse Eif2b3-357M Recombinant Mouse Eif2b3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat EIF2B3-2047R Recombinant Rat EIF2B3 Protein Mammalian Cell His
    Rhesus Macaque EIF2B3-1416R Recombinant Rhesus monkey EIF2B3 Protein, His-tagged Mammalian Cell His
    Chicken EIF2B3-2937C Recombinant Chicken EIF2B3 Mammalian Cell His
    Zebrafish EIF2B3-11300Z Recombinant Zebrafish EIF2B3 Mammalian Cell His

    eif2b3 involved in several pathways and played different roles in them. We selected most pathways eif2b3 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif2b3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF3BA; POP4; RPP40; SARNP; DDX20; EIF4EBP2; NUP37; EIF2B3; NCBP1; EIF1AY

    eif2b3 has several biochemical functions, for example, NOT S-methyl-5-thioribose-1-phosphate isomerase activity, contributes_to guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by eif2b3 itself. We selected most functions eif2b3 had, and list some proteins which have the same functions with eif2b3. You can find most of the proteins on our site.

    Function Related Protein
    NOT S-methyl-5-thioribose-1-phosphate isomerase activity EIF2B2; EIF2B1; EIF2B3; EIF2B4
    contributes_to guanyl-nucleotide exchange factor activity EIF2B4; EIF2B3; LAMTOR3; LAMTOR2; C7orf59; HBXIP; EIF2B1; EIF2B2; ALS2; LAMTOR1
    protein binding MST1R; KPNA3; EIF2AK2; EIF4A3; ITPR1; SRM; SIRT1; TFB1M; SEPT1; MRPS23
    contributes_to translation initiation factor activity EIF2B1; EIF2B4; EIF3HB; EIF3S6IP; EIF3J; EIF3A; EIF3HA; EIF3E; EIF3BA; EIF2B2
    translation initiation factor binding CELF1; RPS24; EIF2B5; EIF3BA; ZFP259; TBL2; ZNF259; EIF3C; POLR2G; EIF3F

    eif2b3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif2b3 here. Most of them are supplied by our site. Hope this information will be useful for your research of eif2b3.

    EIF2B1; STC2; NDUFB8; GOLM1; pi3p; ZWINT; EGFR; Cdk1; NSS; CDC42

    Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
    Wan, JY; Edwards, KL; et al. Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. PARKINSONISM & RELATED DISORDERS 20:93-98(2014).

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