Recombinant Full Length Human EIF2B3 Protein, GST-tagged

• Cat.No.: EIF2B3-4491HF
• Product Overview: Human EIF2B3 full-length ORF ( NP_065098.1, 1 a.a. - 452 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 76.6 kDa
• Protein Length: 452 amino acids
• AA Sequence: MEFQAVVMAVGGGSRMTDLTSSIPK PLLPVGNKPLIWYPLNLLERVGFEE VIVVTTRDVQKALCAEFKMKMKPDI VCIPDDADMGTADSLRYIYPKLKTD VLVLSCDLITDVALHEVVDLFRAYD ASLAMLMRKGQDSIEPVPGQKGKKK AVEQRDFIGVDSTGKRLLFMANEAD LDEELVIKGSILQKHPRIRFHTGLV DAHLYCLKKYIVDFLMENGSITSIR SELIPYLVRKQFSSASSQQGQEEKE EDLKKKELKSLDIYSFIKEANTLNL APYDACWNACRGDRWEDLSRSQVRC YVHIMKEGLCSRVSTLGLYMEANRQ VPKLLSALCPEEPPVHSSAQIVSKH LVGVDSLIGPETQIGEKSSIKRSVI GSSCLIKDRVTITNCLLMNSVTVEE GSNIQGSVICNNAVIEKGADIKDCL IGSGQRIEAKAKRVNEVIVGNDQLM EI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa [ Homo sapiens ]
• Official Symbol: EIF2B3
• Synonyms: EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); translation initiation factor eIF-2B subunit gamma; EIF 2B; EIF2Bgamma; eIF-2B GDP-GTP exchange factor subunit gamma; EIF-2B
• Gene ID: 8891
• mRNA Refseq: NM_001166588
• Protein Refseq: NP_001160060
• MIM: 606273
• UniProt ID: Q9NR50