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Official Full Name eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Background Eukaryotic translation initiation factor 2 subunit 1?is a?protein?that in humans is encoded by the?EIF2S1?gene. Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Synonyms EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eukaryotic translation initiation factor 2 subunit 1; eIF-2-alpha; OTTHUMP00000028404; OTTHUMP00000218025; eukaryotic translation initiation factor 2 subunit alpha
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2S1-12361H Recombinant Human EIF2S1, GST-tagged E.coli GST
    Human EIF2S1-2501H Recombinant Human EIF2S1, His-tagged E.coli His
    Human EIF2S1-3172H Recombinant Human EIF2S1 Protein, GST-tagged Wheat Germ GST
    Human EIF2S1-3542H Recombinant Human EIF2S1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF2S1-371H Recombinant Human EIF2S1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2S1-542HCL Recombinant Human EIF2S1 cell lysate N/A
    Mouse Eif2s1-2775M Recombinant Mouse Eif2s1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse EIF2S1-5087M Recombinant Mouse EIF2S1 Protein Mammalian Cell His
    Rat EIF2S1-2052R Recombinant Rat EIF2S1 Protein Mammalian Cell His
    Rhesus Macaque EIF2S1-1419R Recombinant Rhesus monkey EIF2S1 Protein, His-tagged Mammalian Cell His
    Chicken EIF2S1-1616C Recombinant Chicken EIF2S1 Mammalian Cell His

    eif2s1 involved in several pathways and played different roles in them. We selected most pathways eif2s1 participated on our site, such as ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif2s1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC-family proteins mediated transport ABCC9; ABCF1; CFTR; ABCA4A; ABCE1; ABCC2; EIF2S3; ABCA8; EIF2S1A; ABCD3B
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S FAUB; EIF4H; EIF3K; EIF4A1; EIF2S3; EIF2S1A; EIF2S1; EIF4B; EIF1AXA; EIF4E
    BDNF signaling pathway MAP3K2; CDKL5; CDH2; CNR1; DPYSL2; GRIP1; CSNK2A1P; CSNK2A1; KCNN2; SIRPA
    Cap-dependent Translation Initiation EIF5; EIF2S3; EIF4E; RPL35; EIF4B; EIF1AXA; EIF4A2; EIF4H; EIF4A1; EIF2S1
    Eukaryotic Translation Initiation EIF5; EIF4A1; EIF4H; EIF2S1; EIF2S3; EIF4EB; EIF2S1A; EIF4B; EIF4G1; FAUB
    Formation of the ternary complex, and subsequently, the 43S complex EIF2S1; FAUB; EIF1AXA; EIF1AX; EIF2S1A; EIF2S3; EIF3K
    GTP hydrolysis and joining of the 60S ribosomal subunit EIF5; FAUB; EIF2S1; EIF1AX; EIF3K; EIF2S3; EIF2S1A; EIF1AXA; EIF4H; RPL35
    Gene Expression MED31; RARG; KARS; DDX20; ZNF597; THG1L; THOC4; ZNF468; TRMT44; SFRS3A

    eif2s1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by eif2s1 itself. We selected most functions eif2s1 had, and list some proteins which have the same functions with eif2s1. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding NSUN2; RSRC2; PUS7; SF3B2; DDX50; MYBBP1A; ZC3H11A; EBI3; MYH9; DIEXF
    protein binding RAVER2; GNL3; DYNLT3; MTDH; PARVA; TACR1; WEE1; E2F7; JOSD1; TXNL4B
    ribosome binding SEC61B; NAA16; EIF5A2; MTRF1; RICTOR; ETF1B; RPSA; CPEB2; YTHDF1; EIF6
    translation initiation factor activity AGO2; EIF4EA; EIF1AX; EIF4EB; EIF3EB; EIF3JA; MTIF2; EIF2B5; EIF3J; EIF4G3

    eif2s1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif2s1 here. Most of them are supplied by our site. Hope this information will be useful for your research of eif2s1.

    EIF2AK2; Eif2ak3; DDX3X; EIF2S2; EIF4G2; Dlg4

    Vlahakis, A; Powers, T; et al. A role for TOR complex 2 signaling in promoting autophagy. AUTOPHAGY 10:2085-2086(2014).
    Zhang, XN; Yuan, Y; et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury Involvement of PARK2-dependent mitophagy. AUTOPHAGY 10:1801-1813(2014).

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