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Official Full Name EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
Background Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene. This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Synonyms EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heat and acid stable protein regulated by insulin 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11529MH Mouse Anti-Human Eukaryotic Translation Initiation Factor 4E Binding Protein 1 Monoclonal Antibody Mouse N/A
    Human EIF4EBP1-1397H Recombinant Human EIF4EBP1 Protein, His-tagged E. coli His
    Human EIF4EBP1-154H Recombinant Human EIF4EBP1 protein, His-tagged E.coli His
    Human EIF4EBP1-1845H Recombinant Human EIF4EBP1 protein, His-tagged E.coli His
    Human EIF4EBP1-26388TH Recombinant Human EIF4EBP1, His-tagged His
    Human EIF4EBP1-28496TH Recombinant Human EIF4EBP1 E.coli N/A
    Human EIF4EBP1-3203H Recombinant Human EIF4EBP1 Protein, GST-tagged Wheat Germ GST
    Human EIF4EBP1-3804H Recombinant Human EIF4EBP1, His tagged E.coli His
    Human EIF4EBP1-6649HCL Recombinant Human EIF4EBP1 293 Cell Lysate HEK293 N/A
    Mouse Eif4ebp1-1846M Recombinant Mouse Eif4ebp1 protein, His-tagged E.coli His
    Mouse EIF4EBP1-5110M Recombinant Mouse EIF4EBP1 Protein Mammalian Cell His
    Rat Eif4ebp1-1847R Recombinant Rat Eif4ebp1 protein, His-tagged E.coli His
    Rat EIF4EBP1-2067R Recombinant Rat EIF4EBP1 Protein Mammalian Cell His
    Zebrafish EIF4EBP1-10046Z Recombinant Zebrafish EIF4EBP1 Mammalian Cell His

    EIF4EBP1 involved in several pathways and played different roles in them. We selected most pathways EIF4EBP1 participated on our site, such as AMPK signaling, AMPK signaling pathway, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4EBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4A1; EIF4EB; EIF2S3; EIF2S1; EIF4E; EIF1AXA; EIF3K; EIF4EBP1; EIF4B; FAUB
    Acute myeloid leukemia JUP; NRAS; PIK3CG; PML; CEBPA; PIK3CD; IKBKB; ZBTB16; KRAS; LEF1
    Alpha6-Beta4 Integrin Signaling Pathway CLCA1; EIF4EBP1; PLEC; CD151; CD151L; EIF4EB; DSP; YWHAQ; COL17A1; SMAD3B
    BDNF signaling pathway BCL2L11; FRS3; EIF4E; LINGO1; CSNK2A1; EGR1; EGR2; DOK5; YBX1; CDK5
    Cap-dependent Translation Initiation FAUB; EIF4EBP1; EIF5; EIF2S3; EIF4B; RPL35; EIF2S1A; EIF3K; EIF4H; EIF4EB
    Choline metabolism in cancer PDPK1; MAPK10; PLA2G4D; WAS; RAC1; PLA2G4A; RHEB; RAC3; PDGFB; RAF1

    EIF4EBP1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding, protein binding, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4EBP1 itself. We selected most functions EIF4EBP1 had, and list some proteins which have the same functions with EIF4EBP1. You can find most of the proteins on our site.

    Function Related Protein
    eukaryotic initiation factor 4E binding EIF4EBP2; HHEX; DDX3X; GRA; EIF4G1; LARP1; EIF4EBP3; EIF4EBP1; OTX2; EIF4EBP3L
    protein binding MAP2; GSTM4; PTEN; SPZ1; FAM167A; DUSP15; CCNE1; FAM19A1; SPRYD7; SGCA
    protein phosphatase 2A binding PPP2R4; TP53; SHC1; FOXO1; CTTNBP2NL; AKT1; ANKLE2; IGBP1; MAPT; PPP2R2A
    translation repressor activity TRIM71; EIF4EBP2; SAMD4; PAIP2; IREB2; SAMD4A; CIRBP; PATL2; EIF4EBP3; EIF4EBP1

    EIF4EBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4EBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4EBP1.


    Wang, ZS; Ma, XH; et al. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 94:1243-1253(2012).
    Bidinosti, M; Martineau, Y; et al. Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain. JOURNAL OF BIOLOGICAL CHEMISTRY 285:19402-19408(2010).

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