EPAS1

  • Official Full Name

    endothelial PAS domain protein 1

  • Overview

    This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
  • Synonyms

    EPAS1; endothelial PAS domain protein 1; endothelial PAS domain-containing protein 1; mHLF; EPAS-1; HIF2-alpha; HIF-2-alpha; Hif like protein; HIF-related factor; HIF1alpha-like factor; HIF1 alpha-like factor; HIF-1-alpha-like factor; HLF (HIF1alpha-like;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPAS1-8053H Recombinant Human EPAS1 protein, His-tagged E.coli His Cys339~Gln541 (Accession # Q99814)
Human EPAS1-12475H Recombinant Human EPAS1, GST-tagged E.coli GST 1-350a.a.
Human EPAS1-29318TH Recombinant Human EPAS1 Wheat Germ N/A 320 amino acids
Human EPAS1-150H Recombinant Human EPAS1 protein, His/S-tagged E.coli His/S
Human EPAS1-3349H Recombinant Human EPAS1 Protein, GST-tagged Wheat Germ GST
Human EPAS1-6588HCL Recombinant Human EPAS1 293 Cell Lysate HEK293 N/A
Human EPAS1-3021H Recombinant Human EPAS1 protein, His-tagged E.coli His 521-870 aa
Human EPAS1-4349HF Recombinant Full Length Human EPAS1 Protein, GST-tagged In Vitro Cell Free System GST 870 amino acids
Human EPAS1-2173H Recombinant Human EPAS1 Protein, His-tagged E.coli N-His Lys26-Ile347
Human EPAS1-0330H Recombinant Human EPAS1 Protein (Ala34-Ser392), C-His-tagged Baculovirus-Insect cells C-His Ala34-Ser392
Human EPAS1-2967H Recombinant Human EPAS1 Protein (Leu239-Asn350), N-His tagged E.coli N-His Leu239-Asn350
Mouse EPAS1-5229M Recombinant Mouse EPAS1 Protein Mammalian Cell His
Mouse Epas1-8054M Recombinant Mouse Epas1 protein, His-tagged E.coli His Asp21~Cys336 (Accession # P97481)
Mouse Epas1-151M Recombinant Mouse Epas1 protein, His/S-tagged E.coli His/S
Mouse EPAS1-2808M Recombinant Mouse EPAS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EPAS1-2808M-B Recombinant Mouse EPAS1 Protein Pre-coupled Magnetic Beads HEK293
Rat Epas1-8055R Recombinant Rat Epas1 protein, His-tagged E.coli His Arg24~Glu348 (Accession # Q9JHS1)
Rat Epas1-152R Recombinant Rat Epas1 protein, His/S-tagged E.coli His/S
Rat EPAS1-2115R Recombinant Rat EPAS1 Protein Mammalian Cell His
Rat EPAS1-1772R-B Recombinant Rat EPAS1 Protein Pre-coupled Magnetic Beads HEK293
Rat EPAS1-1772R Recombinant Rat EPAS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken EPAS1-6370C Recombinant Chicken EPAS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EPAS1 Related Research Area

EPAS1 involved in several pathways and played different roles in them. We selected most pathways EPAS1 participated on our site, such as Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerCDC42;RAF1;TP53;FGF3;TRAF3;BID;RALGDS;HRAS;GRB2
Renal cell carcinomaHIF1A;RAPGEF1;AHA-1;HRAS;FH1;PIK3R3;RAF1;TGFB2;TGFB3

EPAS1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPAS1 itself. We selected most functions EPAS1 had, and list some proteins which have the same functions with EPAS1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingXRCC6;ARID5A;SWAP70;HIST1H4C;ZFP536;SIX6A;PHC3;ZNF672;SMTNL
RNA polymerase II transcription factor activity, sequence-specific DNA bindingZSCAN18;RUNX2A;RELB;JUNBB;BETA3;TRP53;ERF;ETV5A;FOXD2
histone acetyltransferase bindingFOXP3;TRIP4;EGR1;NR4A3;TAF7L;PCNA;HIF1A;TP53;MYOCD
protein bindingUBE2L6;EMP3;EPHA7;FAM65B;CRTC2;SKIV2L2;TCEANC;TSC22D3;PAX3
protein heterodimerization activityADORA2A;HIST1H4H;BTBD11;HIST1H2BM;ADD1;HIST1H2AM;PAFAH1B2;PPARD;SYT10
contributes_to sequence-specific DNA bindingFIGLA;TCF3;HNRNPAB;HDAC4;HIF1A;TRIM28;NEUROD1;SMAD4;EPAS1
transcription factor bindingPPP1R13BB;STK36;TFAP2A;POU1F1;DIP2C;IFI16;NKX3-1;UBE2I;HHEX
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMYOG;CTCFL;TBX20;CREB3L2;YBX1;NCOA3;BARHL2;SP1;HNRNPK

EPAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPAS1.

EIF3E; SMAD3; USP8; BBS4; EGLN1; PDK1; PIAS2

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