Recombinant Full Length Human EPAS1 Protein, GST-tagged

• Cat.No.: EPAS1-4349HF
• Product Overview: Human EPAS1 full-length ORF (NP_001421.2, 1 a.a. - 870 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 122.1 kDa
• Protein Length: 870 amino acids
• AA Sequence: MTADKEKKRSSSERRKEKSRDAARC RRSKETEVFYELAHELPLPHSVSSH LDKASIMRLAISFLRTHKLLSSVCS ENESEAEADQQMDNLYLKALEGFIA VVTQDGDMIFLSENISKFMGLTQVE LTGHSIFDFTHPCDHEEIRENLSLK NGSGFGKKSKDMSTERDFFMRMKCT VTNRGRTVNLKSATWKVLHCTGQVK VYNNCPPHNSLCGYKEPLLSCLIIM CEPIQHPSHMDIPLDSKTFLSRHSM DMKFTYCDDRITELIGYHPEELLGR SAYEFYHALDSENMTKSHQNLCTKG QVVSGQYRMLAKHGGYVWLETQGTV IYNPRNLQPQCIMCVNYVLSEIEKN DVVFSMDQTESLFKPHLMAMNSIFD SSGKGAVSEKSNFLFTKLKEEPEEL AQLAPTPGDAIISLDFGNQNFEESS AYGKAILPPSQPWATELRSHSTQSE AGSLPAFTVPQAAAPGSTTPSATSS SSSCSTPNSPEDYYTSLDNDLKIEV IEKLFAMDTEAKDQCSTQTDFNELD LETLAPYIPMDGEDFQLSPICPEER LLAENPQSTPQHCFSAMTNIFQPLA PVAPHSPFLLDKFQQQLESKKTEPE HRPMSSIFFDAGSKASLPPCCGQAS TPLSSMGGRSNTQWPPDPPLHFGPT KWAVGDQRTEFLGAAPLGPPVSPPH VSTFKTRSAKGFGARGPDVLSPAMV ALSNKLKLKRQLEYEEQAFQDLSGG DPPGGSTSHLMWKRMKNLRGGSCPL MPDKPLSANVPNDKFTQNPMRGLGH PLRHLPLPQPPSAISPGENSKSRFP PQCYATQYQDYSLSSAHKVSGMASR LLGPSFESYLLPELTRYDCEVNVPV LGSSTLLQGGDLLRALDQAT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: EPAS1 endothelial PAS domain protein 1 [ Homo sapiens ]
• Official Symbol: EPAS1
• Synonyms: EPAS1; endothelial PAS domain protein 1; endothelial PAS domain-containing protein 1; bHLHe73; HIF 1 alpha like factor; HIF2A; HLF; MOP2; PASD2; EPAS-1; HIF2-alpha; HIF-2-alpha; HIF-1alpha-like factor; HIF-1-alpha-like factor; member of PAS protein 2; PAS domain-containing protein 2; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; basic-helix-loop-helix-PAS protein MOP2; class E basic helix-loop-helix protein 73; ECYT4
• Gene ID: 2034
• mRNA Refseq: NM_001430
• Protein Refseq: NP_001421
• MIM: 603349
• UniProt ID: Q99814