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EXOG

Official Full Name

endo/exonuclease (5-3), endonuclease G-like
Overview

This gene encodes an endo/exonuclease with 5-3 exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5 end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18.
Synonyms

EXOG; endo/exonuclease (5-3), endonuclease G-like; ENDOGL1, ENDOGL2, endonuclease G like 1 , endonuclease G like 2; nuclease EXOG, mitochondrial; ENGL; ENGL a; ENGL b; endo G-like 1; endonuclease G-like 1; endonuclease G-like 2; ENGLA; ENGLB; ENGL-a; EN;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EXOG-12592H	Recombinant Human EXOG, GST-tagged	E.coli	GST	C-term-228a.a.	$319 / 25ug
Human	EXOG-3565H	Recombinant Human EXOG Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EXOG-12593H	Recombinant Human EXOG protein, His-tagged	E.coli	His	228	$319 / 25ug
Human	EXOG-6506HCL	Recombinant Human EXOG 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EXOG Related Articles

EXOG involved in several pathways and played different roles in them. We selected most pathways EXOG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

EXOG has several biochemical functions, for example, endonuclease activity, metal ion binding, nuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOG itself. We selected most functions EXOG had, and list some proteins which have the same functions with EXOG. You can find most of the proteins on our site.

Function	Related Protein
endonuclease activity	RNASE2;CL2;EAR5;EME1;DNASE1L3L;DIS3;FEN1;OGG1;G3BP1
metal ion binding	ZFAT;BRCC3;ADCY6;USP2;MT1HL1;PRDM16;ZNF296;ITGA8;DDAH1
nuclease activity	TMPPE;FANCM;EAR4;ANG4;ZRANB3;EAR5;RNASEL3;ANG3;CNOT6L
nucleic acid binding	CPSF1;ZFPM1;NARS;TRNAU1APB;ZBTB16A;RNASE10;SREK1IP1;DDX51;ZFP14

EXOG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOG here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOG.

Tigchelaar, W; Yu, HJ; et al. Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C155-C163(2015).

Szczesny, B; Brunyanszki, A; et al. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. NUCLEIC ACIDS RESEARCH 42:13161-13173(2014).